Here, we developed the KSD (keloid sensitivity database), which is committed to a comprehensive manual curation of keloid sensitivity factor. By manually curating thousands of published literatures, multiple sensitivity regulation factors （461 biomarkers and 134 drugs）were recorded with appropriated annotation. It contains 209 drivers and 221 suppressors biomarkers, including 275 proteins, 92 RNAs, 32 genes, 27 cells, 13 pathways, and other records. We believe KSD will be a practical and user-friendly web-based tool that may serve as a specialized platform for clinicians and researchers to better understand the detailed mechanisms of keloid sensitivity.