Biomarker

PMID Type Therapy BiomarkerType Biomarker Gene ID Symbol Drug DrugBank ID Target suppressor/driver Expression DetectingTechniques Url Journal Year Title Authors Keywords Country
35803527 biomarker na protein CD14 3674 ITGA2B na na na suppressor increased IHC Qpcr https://pubmed.ncbi.nlm.nih.gov/35803527 Biochim Biophys Acta Mol Basis Dis 2022 Reduced hydration regulates pro-inflammatory cytokines via CD14 in barrier function-impaired skin David Dolivo; Adrian Rodrigues; Lauren Sun; Robert Galiano; Thomas Mustoe; Seok Jong Hong  Atopic dermatitis; Barrier function; CD14; Epidermis; Hypertrophic scar; Inflammation; Keloid; Psoriasis. USA
36083095 biomarker Radiation gene FOXO1 2308 FOXO1 AS1842856 na na driver increased RNA-SEQ https://pubmed.ncbi.nlm.nih.gov/36083095 Int J Radiat Biol 2022 Molecular response of keloids to ionizing radiation: targeting FOXO1 radiosensitizes keloids Min Hong; Xiaoqian Li; Yulan Liu; Wei Mo; Bin Shi; Shigao Chen; Tao Yan; Yuhong Shi; Daojiang Yu; Shuyu Zhang Keloid; FOXO1; ionizing radiation; radiosensitizer. China
35176288 biomarker na protein LARP6 55323 LARP6 na na na driver increased IHC Qpcr https://pubmed.ncbi.nlm.nih.gov/35176288 J Invest Dermatol 2022 LARP6 Regulates Keloid Fibroblast Proliferation, Invasion, and Ability to Synthesize Collagen Lingxi Chen; Yingjun Su; Bin Yin; Shu Li; Xialin Cheng; Yan He; Chiyu Jia na China
36036334 biomarker na LncRNA GNAS-AS1 149775 GNAS-AS1 na na miR-188-5p/RUNX2 driver increased IHC Qpcr,proliferation, migration, and invasion https://pubmed.ncbi.nlm.nih.gov/36036334 Mol Cell Biochem 2022 LncRNA GNAS-AS1 knockdown inhibits keloid cells growth by mediating the miR-188-5p/RUNX2 axis Yun Liu; Lei Li; Jia-Yao Wang; Fei Gao; Xia Lin; Shi-Shuai Lin; Zhi-Yang Qiu; Zun-Hong Liang GNAS-AS1; Keloid; RUNX2; miR-188-5p. China
35754140 biomarker na circRNA hsa_circ_0043688 na na na na miR-145-5p/FGF2 driver increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/35754140 J Clin Lab Anal 2022 Circular RNA hsa_circ_0043688 serves as a competing endogenous RNA for microRNA-145-5p to promote the progression of Keloids via Fibroblast growth factor-2 Ye Liu; Xin Wang; Ziqiao Ni; Yinqiu Li; Jiaqian Song; Fei Zhu; Xiaojing Li  FGF2; Hsa_circ_0043688; keloid fibroblasts; miR-145-5p; proliferation. China
35967914 biomarker na miRNA miR-23b-3p 407011 MIR23B na na miR-23b-3p/A20/RIPK1 driver increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/35967914 Clin Cosmet Investig Dermatol 2022 Inhibition of miR-23b-3p Ameliorates Scar-Like Phenotypes of Keloid Fibroblasts by Facilitating A20 Expression Quan Kuai; Xueping Jian MiR-23b-3p; apoptosis; extracellular matrix; keloid fibroblasts; proliferation. China
36012134 biomarker na cell CD28 and CD8 + T Cells na na na na immunosuppression suppressor increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/36012134 Int J Mol Sci 2022 The Role of CD28 and CD8+ T Cells in Keloid Development Mengjie Shan; Hao Liu; Yan Hao; Kexin Song; Cheng Feng; Youbin Wang CD28; CD8+ T cells; immune microenvironment; keloid; neural network model. China
35953762 biomarker na exosome miR-7704 na na na na na driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35953762 J Zhejiang Univ Sci B 2022 Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study Zeren Shen; Jinjin Shao; Jiaqi Sun; Jinghong Xu na China
36015648 biomarker na protein BRCA1 672 BRCA1 na na NPTX2 suppressor decreased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/36015648 Polymers (Basel) 2022 Comprehensive Analysis of Chromatin Accessibility and Transcriptional Landscape Identified BRCA1 Repression as a Potential Pathological Factor for Keloid Kuixia Xie; Jingrun Yang; Qianqian Yao; Yang Xu; Yonglin Peng; Xinhua Liu ATAC-seq; BRCA1; NPTX2; chromatin accessibility; keloid. China
36082167 biomarker na cell IL6+CSF3+ vascular endothelial cells na na na na NFκB driver na scRNAseq https://pubmed.ncbi.nlm.nih.gov/36082167 Front Bioeng Biotechnol 2022 Activation of the NFκB signaling pathway in IL6+CSF3+ vascular endothelial cells promotes the formation of keloids Delin Liu; Yidi Zhang; Lisha Zhen; Rong Xu; Zhenling Ji; Zheng Ye IL6; NFkB; endothelial cells; keloid; scRNAseq. Bangladesh
36092734 biomarker Radiation cell  FAP + fibroblasts na na na na cell cycle, senescence, energy production driver na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/36092734 Front Cell Dev Biol 2022 Radiation-induced FAP + fibroblasts are involved in keloid recurrence after radiotherapy Yan Gao; Xue Hou; Yuyin Dai; Ting Yang; Kexin Chen fibroblast activation protein alpha; keloid scar; radiation resistance; recurrence; xenotransplantation. China
35595921 biomarker na pathway Warburg Effect na na oxamate na Akt-GSK3β-cyclin d1 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35595921 Aesthetic Plast Surg 2022 Inhibiting Warburg Effect Can Suppress the Biological Activity and Secretion Function of Keloid Fibroblasts Zhiguo Su; Jincai Fan; Liqiang Liu; Hu Jiao; Jia Tian; Cheng Gan; Zengjie Yang; Rong Huang  Keloid; LDHA; Oxamate; Warburg effect. China
35669563 biomarker na protein TGM2 7052 TGM2 na na Immune infiltration driver increased qRT-PCR,  IHC https://pubmed.ncbi.nlm.nih.gov/35669563 Front Mol Biosci 2022 Identification of a Diagnostic Signature and Immune Cell Infiltration Characteristics in Keloids Yijun Xia; Youbin Wang; Yingjie Xiao; Mengjie Shan; Yan Hao; Lingyun Zhang TGM2; diagnostic signature; immune cell infiltration; keloid; ssGSEA. China
35606330 biomarker na protein FBXL6 26233 FBXL6 na na c-MYC driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35606330 Int Wound J 2022 FBXL6 is dysregulated in keloids and promotes keloid fibroblast growth by inducing c-Myc expression Guangdong Feng; Hui Sun; Meishan Piao  Collagen I; Cyclin A1; FBXL6; c-MYC; fibroblast. China
35661430 biomarker na protein TSP1 108314 Tsp1 na na IL6/JAK2/STAT3 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35661430 Exp Dermatol 2022 TSP1 promotes fibroblast proliferation and extracellular matrix deposition via the IL6/JAK2/STAT3 signalling pathway in keloids Qing-Lan Feng; Jing-Jing Gu; Jun-Yi Chen; Wen-Yue Zheng; Hui-Hui Pan; Xue-Yan Xu; Cheng-Cheng Deng; Bin Yang IL6; TSP1; collagen; fibroblast; keloid. China
35757697 biomarker na protein IL-17  3605 IL17A na na IL-17-STAT3-HIF-1α driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35757697 Front Immunol 2022 IL-17 Induces Autophagy Dysfunction to Promote Inflammatory Cell Death and Fibrosis in Keloid Fibroblasts via the STAT3 and HIF-1α Dependent Signaling Pathways Seon-Yeong Lee; A Ram Lee; Jeong Won Choi; Chae Rim Lee; Keun-Hyung Cho; Jung Ho Lee; Mi-La Cho HIF-1α; IL-17; autophagic flux; keloid; stat3. South Korea
35730251 biomarker na protein AEBP1, CREB3L1, RUNX2, and ZNF469 na na na na na na increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35730251 Exp Dermatol 2022 Increased expression of bone/cartilage-associated genes and core transcription factors in keloids by RNA sequencing Pingping Lin; Guohong Zhang; Rui Peng; Mingming Zhao; Hang Li RNA-seq; bone/cartilage; fibroblast; keloid; transcription factors. China
35670224 biomarker na protein PLK4 10733 PLK4 na na apoptosis, cell cycle driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35670224 Cell Prolif 2022 Downregulation of PLK4 expression induces apoptosis and G0/G1-phase cell cycle arrest in keloid fibroblasts Ru-Lin Huang; Chuanqi Liu; Rao Fu; Yuxin Yan; Jing Yang; Xinggang Wang; Qingfeng Li  na China
35709926 biomarker na gene HOXD3 and UNC5C 3232, 8633 HOXD3, UNC5C na na Immune infiltration na na bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/35709926 Genomics 2022 Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis Hanwen Wang; Ziheng Zhou; Yiling Liu; Peng Wang; Lei Chen; Shaohai Qi; Julin Xie; Jinming Tang Characteristic genes; Immune infiltration; Keloid; LASSO; WGCNA. China
35872873 biomarker na miRNA  miR-29a-3p 407021 MIR29A na na na na decreased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/35872873 Biomed Res Int 2022 Identifying miRNAs Associated with the Progression of Keloid through mRNA-miRNA Network Analysis and Validating the Targets of miR-29a-3p in Keloid Fibroblasts Yan He; Zexin Zhang; Bin Yin; Shu Li; Peng Wang; Junhong Lan; Wenqin Lian; Chiyu Jia na China
35873644 biomarker na drug Loureirin A na na na na TGF-β1/Smad na na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/35873644 Evid Based Complement Alternat Med 2022 Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF- β 1/Smad Signalling Pathway Hui Ma; Xingwu Duan; Runtian Zhang; Hang Li; Yang Guo; Ye Tian; Min Huang; Guangshan Chen; Zi Wang; Lingling Li na China
35887263 biomarker na protein Mortalin 3313 HSPA9 na na α-SMA, pSmad2/3 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35887263 Int J Mol Sci 2022 Effect of Mortalin on Scar Formation in Human Dermal Fibroblasts and a Rat Incisional Scar Model Bok Ki Jung; Tai Suk Roh; Hyun Roh; Ju Hee Lee; Chae-Ok Yun; Won Jai Lee  adenovirus; fibrogenesis; interleukin-1α receptor; keloid; mortalin; scar. South Korea
35987744 biomarker na lncRNA HOXA11-AS 221883 HOXA11-AS na na miR-182-5p driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/35987744 Burns 2022 Long non-coding RNA HOXA11-AS contributes to the formation of keloid by relieving the inhibition of miR-182-5p on ZNF217 Anfang Zou; Peng Liu; Tian Liu; Qin Li HOXA11-AS; Keloid; MiR-182-5p; ZNF217. China
35876480 biomarker na miRNA miR-7-5p na na na na  GAB1 driver decreased qRT-PCR, MTT https://pubmed.ncbi.nlm.nih.gov/35876480 Cell Cycle 2022 Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1 Mengying Zhu; Yonglin Li; Linbo Liu; Xiaomei Zhai  GAB1; Keloid; circ_0057452; miR-7-5p. China
35123990 biomarker na cell fibrovascular communication and mesenchymal activation of endothelial cells na na na na na na increased Single-Cell and Spatial Transcriptomics https://pubmed.ncbi.nlm.nih.gov/35123990 J Invest Dermatol 2022 Integrated Analysis of Single-Cell and Spatial Transcriptomics in Keloids: Highlights on Fibrovascular Interactions in Keloid Pathogenesis Joonho Shim; Se Jin Oh; Eunhye Yeo; Ji Hye Park; Jai Hee Bae; Seok-Hyung Kim; Dongyoun Lee; Jong Hee Lee na South Korea
35628356 biomarker na na ASC-J9 na na ASC-J9 DB06133 STAT3 suppressor increased RNA seq, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/35628356 Int J Mol Sci 2022 ASC-J9 Blocks Cell Proliferation and Extracellular Matrix Production of Keloid Fibroblasts through Inhibiting STAT3 Signaling Yi-Kai Hong; Chen-Han Wu; Yu-Chen Lin; Yu-Lun Huang; Kuo-Shu Hung; Tsung-Pin Pai; Yen-Ting Liu; Tzu-Chi Chen; Hardy Chan; Chao-Kai Hsu ASC-J9; ECM production; STAT3; cell proliferation; keloid fibroblast. China
35702126 biomarker na mRNA IL-4 3565 IL4 na na na driver increased bioinformatic approaches, qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35702126 Am J Transl Res 2022 IL-4 and CCR7 play an important role in the development of keloids in patients with a family history Mengjie Shan; Hao Liu; Yan Hao; Tian Meng; Cheng Feng; Kexin Song; Youbin Wang  Keloids; bioinformatics; differentially expressed genes; family history. China
35702126 biomarker na mRNA CCR7 1236 CCR7 na na na suppressor decreased bioinformatic approaches, qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35702126 Am J Transl Res 2022 IL-4 and CCR7 play an important role in the development of keloids in patients with a family history Mengjie Shan; Hao Liu; Yan Hao; Tian Meng; Cheng Feng; Kexin Song; Youbin Wang  Keloids; bioinformatics; differentially expressed genes; family history. China
35546288 biomarker na protein Axin-2 8313 AXIN2 na na na driver increased IHC https://pubmed.ncbi.nlm.nih.gov/35546288 J Cosmet Dermatol 2022 Immunohistochemical expression of Axin-2, as an implication of the role of stem cell in scar pathogenesis and prognosis Heba A S Bazid; Rehab Monir Samaka; Marwa E A Mousa; Iman Seleit  Axin-2; atrophic scars; hypertrophic scars; keloids; wound healing. Egypt
35547861 biomarker na protein HOXC6 5770 PTPN1 na na  HIF-1α/HOXC6/ERK driver increased bioinformatic approaches,  https://pubmed.ncbi.nlm.nih.gov/35547861 Burns Trauma 2022 Multitranscriptome analyses of keloid fibroblasts reveal the role of the HIF-1α/HOXC6/ERK axis in keloid development Qi Wang; Yixiu Zhong; Zhijia Li; Dingheng Zhu; Hongyan Lu; Pingjiao Chen; Changxing Li; Xuebiao Peng; Qian Li; Kang Zeng  ERK; Fibroblast; HIF-1α; HOXC6; Keloid; Transcriptome. China
35706403 biomarker na circRNA hsa_circ_0057452 na na na na RNA-1225-3p/AF4/FMR2 driver increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/35706403 Bioengineered 2022 Circular RNA hsa_circ_0057452 facilitates keloid progression by targeting the microRNA-1225-3p/AF4/FMR2 family member 4 axis Hu Gao; Zhen Hu; Xiangming Zhang  AFF4; Hsa_circ_0057452; KF; keloid; miR-1225-3p. China
35416391 biomarker na protein Krox20 1959 EGR2 na na na driver increased IHC https://pubmed.ncbi.nlm.nih.gov/35416391 J Cosmet Dermatol 2022 Krox20 expression in abnormal scars: An immunohistochemical study Ola A Bakry; Rehab M Samaka; Nansy Fayez; Iman Seleit  Krox20; atrophic scar; hypertrophic scar; keloid; scars. Egypt
35441794 biomarker na protein TRAF3IP2 10758 TRAF3IP2 na na TGF-β1/Smad driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35441794 J Cosmet Dermatol 2022 TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation, migration, and extracellular matrix deposition in keloid through the TGF-β1/Smad pathway Qiaoyu Yan; Bin Li ECM deposition; FOXO4; TRAF3IP2; fibroblast proliferation; keloid; migration. China
35610079 biomarker na circRNA CircSLC8A1 na na na na miR-181a-5p/HIF1AN suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/35610079 Burns 2022 CircSLC8A1 targets miR-181a-5p/HIF1AN pathway to inhibit the growth, migration and extracellular matrix deposition of human keloid fibroblasts Xiaoye Yuan; Baiye Chen; Xueming Wang CircSLC8A1; HIF1AN; Human keloid fibroblasts; Keloid; MiR-181a-5p. China
34687743 biomarker na protein FOXF2 2295 FOXF2 na na na driver increased qRT-PCR, WB, RNA-seq https://pubmed.ncbi.nlm.nih.gov/34687743 J Invest Dermatol 2022 A Methylome and Transcriptome Analysis of Normal Human Scar Cells Reveals a Role for FOXF2 in Scar Maintenance Andrew W Stevenson; Phillip E Melton; Eric K Moses; Hilary J Wallace; Fiona M Wood; Suzanne Rea; Patricia L Danielsen; Mansour Alghamdi; Nicole Hortin; Julia Borowczyk 0; Zhenjun Deng; Mitali Manzur; Mark W Fear na Australia
35491288 biomarker na lncRNA HOXA11-AS 221883 HOXA11-AS na na miR-188-5p/VEGFA driver increased qRT-PCR, CCK8 https://pubmed.ncbi.nlm.nih.gov/35491288 J Dermatol Sci 2022 HOXA11-AS facilitates the proliferation, cell cycle process and migration of keloid fibroblasts through sponging miR-188-5p to regulate VEGFA Xiaolong Zhou; Jiaoyang Lu; Ben Wu; Zhen Guo Fibroblasts; HOXA11-AS; Keloid; MiR-188–5p; VEGFA. China
35432479 biomarker na lncRNA HOXA11-AS 221883 HOXA11-AS na na HOXA11-AS-three miRNAs-NIPAL3 na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/35432479 Front Genet 2022 Construction of a HOXA11-AS-Interact Ed Network in Keloid Fibroblasts Using Integrated Bioinformatic Analysis and in Vitro Validation Qiang Wang; Wei Wang; Xiao-Jie Sun HOXA11-AS; competing endogenous RNA; integrated molecular network; keloid fibroblast; validation. China
34110956 biomarker na protein CXCR4,CXCL9 7852, 4283 CXCR4, CXCL9 na na apoptosis na increased bioinformatic approaches, qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/34110956 J Plast Surg Hand Surg 2022 A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis Xinhang Dong; Mingzi Zhang; Yuanjing Chen; Chengcheng Li; Youbin Wang; Xiaolei Jin  Keloid; apoptosis; dermal vascular endothelial cells; differentially expressed genes; inflammation. China
35039632 biomarker na cell CD8+ T-cell  na na na na NKG2A-soluble HLA-E na decreased Single-cell RNA sequencing https://pubmed.ncbi.nlm.nih.gov/35039632 Cell Mol Immunol 2022 Downregulated cytotoxic CD8+ T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids Heng Xu; Zhu Zhu; Jian Hu; Jiawei Sun; Yan Wo; Xianshu Wang; Hongzhi Zou; Bin Li; Yixin Zhang Biomarker; Keloid; T cell immunology. China
35079927 biomarker na circRNA circPDE7B  na na na na  miR-661 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35079927 Mol Cell Biochem 2022 CircPDE7B/miR-661 axis accelerates the progression of human keloid fibroblasts by upregulating fibroblast growth factor 2 (FGF2) Fenglian Wu; Hongbin He; Yanxin Chen; Donglai Zhu; Tao Jiang; Jiaxin Wang FGF2; Fibroblasts; Keloid; circPDE7B; miR-661. China
35278628 biomarker na cell Schwann cell na na na na macrophage driver increased Single-cell RNA sequencing https://pubmed.ncbi.nlm.nih.gov/35278628 Matrix Biol 2022 Schwann cells contribute to keloid formation Martin Direder; Tamara Weiss; Dragan Copic; Vera Vorstandlechner; Maria Laggner; Karin Pfisterer; Caterina Selina Mildner; Katharina Klas; Daniel Bormann; Werner Haslik; Christine Radtke; Matthias Farlik; Lisa Shaw; Bahar Golabi; Erwin Tschachler; Konrad Hoetzenecker; Hendrik Jan Ankersmit; Michael Mildner Extracellular matrix; Keloid; Macrophage; Schwann cell; Single-cell RNA sequencing. Austria
35333672 biomarker na exosome adMSC-Exos na na na na TGF-β2, Notch-1 suppressor na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35333672 Bioengineered 2022 Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression Jing Li; Zhiyu Li; Song Wang; Jianhai Bi; Ran Huo Adipose-derived mesenchymal stem cells; TGF-β/smad signaling; exosome; extracellular matrix; keloid fibroblasts. China
35184918 biomarker na circRNA CircCOL5A1 na na na na miR-877-5p/EGR1 suppressor increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35184918 Burns 2022 CircCOL5A1 inhibits proliferation, migration, invasion, and extracellular matrix production of keloid fibroblasts by regulating the miR-877-5p/EGR1 axis Hongbo Jiao; Geng Ji; Binjie Luo; Chuanjun Chen EGR1; Fibroblasts; Keloid; circCOL5A1; miR-877–5p. China
35047146 biomarker na mRNA BMP4, MSX1, HAND2, TBX2, SIX1, IRX1, EDN1, DLX5, MEF2C, and DLX2 na na na na extracellular structure organization, vascular smooth muscle contraction, and the cGMP-PKG signaling na na bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/35047146 J Healthc Eng 2022 Identification of Hub Genes of Keloid Fibroblasts by Coexpression Network Analysis and Degree Algorithm Xianglan Li; Rihua Jiang; Haiguo Jin; Zhehao Huang na China
35082796 biomarker na cell CD4+ T-cell, CD8+ T-cell  na na na na Inflammation and Immune na na bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/35082796 Front Immunol 2022 The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses Yang Li; Min Li; Caijie Qu; Yongxi Li; Zhanli Tang; Zhike Zhou; Zengzhao Yu; Xu Wang; Linlin Xin; Tongxin Shi  fibroblasts; genome-wide expression; immune response; inflammation; keloid; molecular alterations. China
35012558 biomarker na lncRNA XLOC_000587, AF268386, etc na na na na na na na bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/35012558 Biomed Eng Online 2022 Detection and analysis of long noncoding RNA expression profiles related to epithelial-mesenchymal transition in keloids Zhixiong Chen; Xi Chu; Jinghong Xu Epithelial-mesenchymal transition; Keloid; Long noncoding RNA. China
35115816 biomarker na miRNA miR-30b-5p, miR-212-3p, miR-149-5p na na na na SIX1, CCNA2, CCNB1, FOXM1, RUNX2 na na bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/35115816 Int J Gen Med 2022 Identification and Validation of Novel Diagnostic Biomarkers for Keloid Based on GEO Database Yeletai Nurzati; Zhu Zhu; Heng Xu; Yixin Zhang  diagnostic biomarkers; differentially expressed genes; keloids; miRNA–mRNA network. China
35174214 biomarker na circRNA hsa _ circ _ 0006867 na na na na Argonaute 2 driver increased bioinformatic approaches, qRT-PCR https://pubmed.ncbi.nlm.nih.gov/35174214 Front Mol Biosci 2022 Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts Qianqian Pang; Xiaohu Lin; Jiaqi Sun; Jie Hu; Siya Dai; Yichen Shen; Mingyuan Xu; Jinghong Xu  ceRNA network; circular RNA; dermal fibroblast; keloid; miRNA sponge; microarray analysis. China
34370343 biomarker na protein PTP1B 5770 PTPN1 ERK inhibitor na MAPK/ERK suppressor decreased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/34370343 Exp Dermatol 2022 Protein tyrosine phosphatase 1B regulates fibroblasts proliferation, motility and extracellular matrix synthesis via the MAPK/ERK signalling pathway in keloid Leqi Qian; Qiang Wang; Chuanyuan Wei; Lu Wang; Yanwen Yang; Xinyi Deng; Jiaqi Liu; Fazhi Qi  ERK inhibitor; extracellular matrix; keloid; keloid fibroblasts; lentivirus infection; motility; normal fibroblasts; proliferation; protein tyrosine phosphatase 1B; therapeutic target. China
35068324 biomarker na circRNA PTPN12 5782 PTPN12 na na Wnt suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/35068324 Bioengineered 2022 Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p Fei Liu; Tao Li; Xiaoan Zhan cell viability; circPTPN12; keloid; keloid fibroblasts; miR-21-5p. China
35222522 biomarker na compound 5-Hydroxylysine, 1-Methylnicotinamide na na na na na na na Metabolomic Profiling https://pubmed.ncbi.nlm.nih.gov/35222522 Front Genet 2022 Metabolomic Profiling Reveals That 5-Hydroxylysine and 1-Methylnicotinamide Are Metabolic Indicators of Keloid Severity Mengjie Shan; Hao Liu; Yan Hao; Kexin Song; Tian Meng; Cheng Feng; Youbin Wang; Yongsheng Huang PLS-DA; keloid; machine learning; metabolomic; neural network model; random forest. China
34623712 biomarker na protein YAP/TAZ 10413 YAP1 Verteporfin DB00460 na driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34623712 Exp Dermatol 2022 Targeted inhibition of YAP/TAZ alters the biological behaviours of keloid fibroblasts Na Gao; Lulu Lu; Xiaolei Ma; Zhengyi Liu; Shuxia Yang; Gangwen Han  YAP/TAZ; fibroblasts; keloid; verteporfin. China
34665886 biomarker na cell macrophage na na na na na driver na na https://pubmed.ncbi.nlm.nih.gov/34665886 Exp Dermatol 2022 Important role of mechanical microenvironment on macrophage dysfunction during keloid pathogenesis Boya Zhou; Zhen Gao; Wei Liu; Xiaoli Wu; Wenbo Wang  keloids; macrophages; mechanical microenvironment; stretching tension; tissue stiffness. China
34978504 biomarker na protein ADAM17 6868 ADAM17 na na EGFR/ERK  driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34978504 J Plast Surg Hand Surg 2022 ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway Xin Le; You-Fen Fan  ADAM17; EGFR/ERK signaling pathway; extracellular matrix; fibroblast; keloid. China
34974806 biomarker na lncRNA H19 283120 H19 na na miR-196b-5p  driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34974806 Bioengineered 2022 Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p Zhichao Li; Cheng Gong; Huiming Wei keloid; lncRNA H19; miR-196b-5p; smad5. China
31986937 biomarker na protein TSG-6 7130 TNFAIP6 na na TGF-β1/Smad suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31986937 J Invest Surg 2021 TSG-6 Inhibits the Growth of Keloid Fibroblasts Via Mediating the TGF-β1/Smad Signaling Pathway Xin-Yi Li; Xiao-Juan Weng; Xiao-Jing Li; Xiao-Yu Tian  Human keloid fibroblasts; Smad; TNFα-stimulated gene-6; plasminogen activator inhibitor-1; TGFr β1. China
33323304 biomarker na miRNA miR-424-3p 494336 MIR424 na na na na increased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/33323304 Burns 2021 Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro Wenchang Lv; Yuping Ren; Min Wu; Xiao Luo; Jing Yu; Qi Zhang; Yiping Wu Bioinformatics; Keloids; Smad7; TGF-β1/Smad pathway; miR-424-3p. China
33811779 biomarker na mRNA HOX genes na na na na HOXA9 driver decreased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/33811779 Wound Repair Regen 2021 Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin Jennifer M Hahn; Kevin L McFarland; Kelly A Combs; Meridith C Anness; Dorothy M Supp fibroblast; homeobox genes; keloid. USA
34486677 biomarker na lncRNA LINC00937 389634 LINC00937 na na miR-28-5p/MC1R suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34486677 Histol Histopathol 2021 LINC00937 suppresses keloid fibroblast proliferation and extracellular matrix deposition by targeting the miR-28-5p/MC1R axis Jing Wan; Xiao-Lei He; Qi-Chao Jian; Zhi-Feng Fan; Ying Shi; Long-Fei Luo na China
34514006 biomarker na cell Adipose-derived stem cells na na na na arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34514006 Burns Trauma 2021 Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine Jinxiu Yang; Shiyi Li; Leren He; Minliang Chen  Adipose-derived stem cells; Anti-fibrosis, cyclooxygenase-2; Apoptosis; Arachidonic acid; Fibroblasts; Keloids. China
35003102 biomarker na mRNA Tenascin-C 3371 TNC na na na na decreased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/35003102 Front Immunol 2021 Single-Cell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases Identified That TNC Is a Novel Biomarker for Keloid Jiaheng Xie; Liang Chen; Yuan Cao; Dan Wu; Wenwen Xiong; Kai Zhang; Jingping Shi; Ming Wang  Tenascin-c; differential expression analysis; keloid; single-cell sequencing; weighted co-expression network analysis. China
34571584 biomarker na LncRNA HOXA11-AS 221883 HOXA11-AS na na  miR-148b-3p/IGFBP5  na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34571584 Basic Clin Pharmacol Toxicol 2021 Botulinum toxin A promotes the transdifferentiation of primary keloid myofibroblasts into adipocyte-like cells Xing Dai; Tie-Chi Lei BMP4/Smad signalling pathway; adipocytes; botulinum toxin A; keloid; myofibroblasts. China
34571584 biomarker na compound Botulinum toxin A na na na na transdifferentiation suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34571584 Basic Clin Pharmacol Toxicol 2021 Botulinum toxin A promotes the transdifferentiation of primary keloid myofibroblasts into adipocyte-like cells Xing Dai; Tie-Chi Lei BMP4/Smad signalling pathway; adipocytes; botulinum toxin A; keloid; myofibroblasts. China
33315500 biomarker na protein ATF3 467 ATF3 na na TGF-beta, SMAD  driver na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33315500 Bioengineered 2021 Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway Xue-Ming Wang; Xiu-Mei Liu; Yuting Wang; Zhen-Yu Chen Keloid; activating transcription factor 3; invasion; proliferation. China
34146092 biomarker na miRNA microRNA-21 406991 MIR21 na na  Smad7 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34146092 J Burn Care Res 2021 Exosomal MicroRNA-21 Promotes Keloid Fibroblast Proliferation and Collagen Production by Inhibiting Smad7 Qijie Li; Lu Fang; Junjie Chen; Siqi Zhou; Kai Zhou; Fengrui Cheng; Ying Cen; Yong Qing; Junliang Wu na China
34492266 biomarker na protein Kindlin-2 10979 FERMT2 na na Smad, Fas/FasL driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34492266 Exp Cell Res 2021 Kindlin-2 promoted the progression of keloids through the Smad pathway and Fas/FasL pathway Shaobin Huang; Jing Liao; Xiaohua Luo; Fang Liu; Ge Shi; Weiping Wen Fas/FasL; Keloid fibroblasts; Kindlin-2; Smad3. China
34600545 biomarker na protein GNG13, ADCY8, NPY, hTR1A na na na na SP1, hsa-mir-372, hsa-mir-20, hsa-mir-10b na increased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/34600545 BMC Med Genomics 2021 Integrated bioinformatics analysis of core regulatory elements involved in keloid formation Chuying Li; Meitong Jin; Yinli Luo; Zhehu Jin; Longquan Pi Integrated bioinformatics analysis; Keloids; MicroRNAs; Transcription factor. China
33899950 biomarker na mRNA MDFI  4188 MDFI na na na na increased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/33899950 Clin Exp Dermatol 2021 Multifaceted array-based keloidal gene expression profiling reveals specific MDFI upregulation in keloid lesions M Asai; Y Koike; Y Kuwatsuka; Y Yagi; K Kashiyama; K Tanaka; H Mishima; K Yoshiura; A Utani; H Murota  na Japan
33475023 biomarker na protein MeCP2 4204 MECP2 na na Smad7 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/33475023 J Plast Surg Hand Surg 2021 Association between MeCP2 and Smad7 in the pathogenesis and development of pathological scars Dan Li; E Yang; Juan Zhao; Hengshu Zhang  MECP2; Smad7 methylation; hypertrophic scar; keloid. China
34621503 biomarker na miRNA miR-34a 407040 MIR34A na na SATB1 suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34621503 J Healthc Eng 2021 Study on the Mechanism of miR-34a Affecting the Proliferation, Migration, and Invasion of Human Keloid Fibroblasts by Regulating the Expression of SATB1 Lei Jiang; Xiufang Shi; Meng Wang; Huaxia Chen na China
34483675 biomarker na protein TGF-β1/SMAD 7040, 4087 TGFB1, SMAD2 na na DPP4-CXCL12 na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34483675 J Inflamm Res 2021 Dysregulation of DPP4-CXCL12 Balance by TGF-β1/SMAD Pathway Promotes CXCR4+ Inflammatory Cell Infiltration in Keloid Scars ZongAn Chen; Zhen Gao; LingLing Xia; XiaoQing Wang; LiMing Lu; XiaoLi Wu  CXCL12; DPP4; TGF-β1; chemokines; inflammation; keloid. China
34048784 biomarker na LncRNA LINC01116 375295 LINC01116 na na TGF-β1/SMAD3 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34048784 Anal Biochem 2021 LINC01116 regulates proliferation, migration, and apoptosis of keloid fibroblasts by the TGF-β1/SMAD3 signaling via targeting miR-3141 Dan Wu; JinJie Zhou; Ming Tan; Yanshijing Zhou  Keloids; LINC01116; TGF-β1/SMAD3 signaling; miR-3141. China
34887123 biomarker na LncRNA Lnc-H19 na na na na miR-214-5p/FGF2 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34887123 Burns 2021 Lnc-H19 enhances anaerobic glycolysis of keloid fibroblasts by targeting the miR-214-5p/FGF2 axis Junxu Lu; Yuanbo Wang; Yanuan Hu; Biaobing Yang FGF2; Hypoxia; KD; lnc-H19; lncRNA; miR-214-5p. China
34253698 biomarker na protein CXCL12 6387 CXCL12 na na inflammation suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34253698 Ann Plast Surg 2021 Systemic Fibrocyte Levels and Keloid Expression of the Chemoattractant CXCL12 Are Upregulated Compared With Patients With Normal Scar Chris A Campbell; Marie D Burdick, Robert M Strieter na UK
33842249 biomarker na exosome adipose-derived stem cell exosomes na na na na TGF-β1/Smad  suppressor na qRT-PCR, WB. cck8 https://pubmed.ncbi.nlm.nih.gov/33842249 Gland Surg 2021 The effect of inhibiting exosomes derived from adipose-derived stem cells via the TGF-β1/Smad pathway on the fibrosis of keloid fibroblasts Zhi-Yuan Wu; Hui-Jun Zhang; Zhi-Hong Zhou; Zhan-Peng Li; Si-Mu Liao; Ze-Yong Wu; Hai-Hua Huang; Yu-Cang Shi  TGF-β; adipose stem cells; exosomes; keloid fibroblasts. China
33662027 biomarker na compound folic acid 108684022 FRAXA na na  JAK1/2, STAT3 driver na IF https://pubmed.ncbi.nlm.nih.gov/33662027 PLoS One 2021 Differential responses to folic acid in an established keloid fibroblast cell line are mediated by JAK1/2 and STAT3 Katelyn J McCann; Manoj Yadav; Mohammadali E Alishahedani; Alexandra F Freeman; Ian A Myles na USA
33758530 biomarker na protein Adiponectin 9370 ADIPOQ na na Anti-Inflammation, Anti-Fibrosis Factor na decreased VSS, Qpcr https://pubmed.ncbi.nlm.nih.gov/33758530 J Inflamm Res 2021 Adiponectin, but Not TGF-β1, CTGF, IL-6 or TNF-α, May Be a Potential Anti-Inflammation and Anti-Fibrosis Factor in Keloid Limin Luo; Jun Li; Yuran Wu; Jianjun Qiao; Hong Fang  Vancouver Scar Scale scores; adiponectin; fibrosis; inflammatory factors; keloid. China
33860039 biomarker na mRNA COL5A1, COL5A2, SERPINH1 na na na na na driver na bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/33860039 Biomed Res Int 2021 Bioinformatic Analysis of Key Genes and Pathways Related to Keloids Siwei Bi; Ruiqi Liu; Beiyi Wu; Linfeng He; Jun Gu na China
33616676 biomarker na protein PAX5 5079 PAX5 na na SNd1 driver decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33616676 Inflamm Res 2021 PAX5 activates telomerase activity and proliferation in keloid fibroblasts by transcriptional regulation of SND1, thus promoting keloid growth in burn-injured skin Gaoping Qin; Yaowen Sun; Yadong Guo; Yong Song Burn; Keloid; PAX5; SND1; Telomerase activity; Transcriptional regulation. China
32883538 biomarker na LncRNA LINC01116 375295 LINC01116 na na miR-203/SMAD5 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32883538 Burns 2021 Long non-coding RNA LINC01116 accelerates the progression of keloid formation by regulating miR-203/SMAD5 axis Weiwei Yuan; Hui Sun; Li Yu Keloid formation; LINC01116; SMAD5; miR-203. China
33649815 biomarker na circRNA CircnrIP1 na na na na  FXR1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33649815 Int J Mol Med 2021 circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p Baolin Wang; Hang Yin; Hongmei Zhang; Tiantian Wang  keloid; circular nuclear receptor interacting protein 1; Fragile‑X mental retardation 1; microRNA‑503‑3p; microRNA‑503‑5p. China
33791011 biomarker na protein TNF-α 7124 TNF na na NF-κB, JNK, p38 MAPK driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/33791011 Exp Ther Med 2021 Increased sensitivity to TNF-α promotes keloid fibroblast hyperproliferation by activating the NF-κB, JNK and p38 MAPK pathways Qijie Li; Fengrui Cheng; Kai Zhou; Lu Fang; Junliang Wu; Qingjie Xia; Ying Cen; Junjie Chen; Yong Qing keloid fibroblasts; proliferation; sensitivity; tumor necrosis factor receptor 1; tumor necrosis factor-α. China
34070830 biomarker na protein GLUT-1 6513 SLC2A1 na na Glycolysis, Oxidative Stress, Fibroblast Proliferation na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34070830 Life (Basel) 2021 GLUT-1 Enhances Glycolysis, Oxidative Stress, and Fibroblast Proliferation in Keloid Ying-Yi Lu; Chieh-Hsin Wu; Chien-Hui Hong; Kee-Lung Chang; Chih-Hung Lee GLUT-1; glycolysis; keloids; proliferation; ROS. China
34140509 biomarker na na na na na na na fibroblast heterogeneity na increased RNA-seq https://pubmed.ncbi.nlm.nih.gov/34140509 Nat Commun 2021 Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases Cheng-Cheng Deng; Yong-Fei Hu; Ding-Heng Zhu; Qing Cheng; Jing-Jing Gu; Qing-Lan Feng; Li-Xue Zhang; Ying-Ping Xu; Dong Wang; Zhili Rong; Bin Yang na China
34105826 biomarker na gene Asporin 54829 ASPN na na intercellular mechanocommunications suppressor na RNA-seq, IHC https://pubmed.ncbi.nlm.nih.gov/34105826 FASEB J 2021 Asporin inhibits collagen matrix-mediated intercellular mechanocommunications between fibroblasts during keloid progression Longwei Liu; Hongsheng Yu; Yi Long; Zhifeng You; Rei Ogawa; Yanan Du; Chenyu Huang ASPN; fibroblast; fibrosis; intercellular mechanocommunication; keloid. China
32890866 biomarker na protein Epac 10411 RAPGEF3 ESI-09 na Akt suppressor na IF, WB https://pubmed.ncbi.nlm.nih.gov/32890866 J Surg Res 2021 Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts Wenchang Lv; Shengxuan Liu; Qi Zhang; Zhen Yi; Xiaoyong Bao; Youping Feng; Yuping Ren Akt; ESI-09; Epac1; Keloid. China
33200800 biomarker na miRNA miR-194-5p 406969 MIR194-1 na na NR2F2 suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33200800 Mol Med Rep 2021 miR-194-5p serves a suppressive role in human keloid fibroblasts via targeting NR2F2 Qijun Xu; Shengjun Jiang keloid; microRNA‑194‑5p; nuclear receptor subfamily 2 group F member 2. China
33200804 biomarker na protein Runx2 860 RUNX2 na na PI3K/AKT suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33200804 Mol Med Rep 2021 Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway Wenchang Lv; Min Wu; Yuping Ren; Xiao Luo; Weijie Hu; Qi Zhang; Yiping Wu  runt‑related  transcription  factor 2; keloid  fibroblasts; Pi3K/AKT signalin. China
33007201 biomarker na protein FSTL1 11167 FSTL1 na na TGF-β1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33007201 Mol Ther 2021 Targeting FSTL1 for Multiple Fibrotic and Systemic Autoimmune Diseases Xiaohe Li; Yinshan Fang; Dingyuan Jiang; Yingying Dong; Yingying Liu; Si Zhang; Jiasen Guo; Chao Qi; Chenjing Zhao; Fangxin Jiang; Yueyue Jin; Jing Geng; Cheng Yang; Hongkai Zhang; Bin Wei; Jiurong Liang; Chen Wang; Huaping Dai; Honggang Zhou; Dianhua Jiang; Wen Ning autoimmune diseases; follistatin-like 1; neutralizing antibodies; organ fibrosis; therapeutic strategy. China
33436666 biomarker na protein CRIF1 90480 GADD45GIP1 na na TGF-β/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33436666 Sci Rep 2021 Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-β/Smad signaling pathway Harsha Nagar; Sungmin Kim; Ikjun Lee; Seonhee Kim; Su-Jeong Choi; Shuyu Piao; Byeong Hwa Jeon; Sang-Ha Oh; Cuk-Seong Kim na South Korea
33553184 biomarker na circRNA CircCOL5A1 na na na na PI3K/Akt  driver increased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33553184 Front Cell Dev Biol 2021 Circular RNA CircCOL5A1 Sponges the MiR-7-5p/Epac1 Axis to Promote the Progression of Keloids Through Regulating PI3K/Akt Signaling Pathway Wenchang Lv; Shengxuan Liu; Qi Zhang; Weijie Hu; Yiping Wu; Yuping Ren  Epac1; PI3K/Akt pathway; circCOL5A1; fibroblast; keloid; miR-7-5p. China
33235042 biomarker na cell CD206+ Macrophages  na na na na IL-6 suppressor na co-culture https://pubmed.ncbi.nlm.nih.gov/33235042 Plast Reconstr Surg 2021 Human CD206+ Macrophages Show Antifibrotic Effects on Human Fibroblasts through an IL-6-Dependent Mechanism In Vitro Isao Kurachi; Erina Kurita; Akihiko Takushima; Hirotaka Suga  na Japan
33456506 biomarker na cell Adipose-derived mesenchymal stem cells na na SB431542 na TGF-β1 suppressor na cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33456506 Exp Ther Med 2021 Adipose-derived mesenchymal stem cells inhibit cell proliferation and migration and suppress extracellular matrix synthesis in hypertrophic-scar and keloid fibroblasts Fang Xie; Li Teng; Jiajie Xu; Jianjian Lu; Chao Zhang; Liya Yang; Xiaoyang Ma; Minghao Zhao  adipose-derived mesenchymal stem cells; extracellular matrix; fibroblasts; migration; proliferation. China
33162101 biomarker na LncRNA NEAT1 283131 NEAT1 na na miR-196b-5p/FGF2 driver increased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33162101 J Surg Res 2021 NEAT1 Knockdown Inhibits Keloid Fibroblast Progression by miR-196b-5p/FGF2 Axis Jingzhe Yang; Pingyang Deng; Yonggang Qi; Xinshu Feng; Hailing Wen; Fengping Chen ECM; FGF2; Keloid; NEAT1; miR-196b-5p. China
33261854 biomarker na LncRNA HOXA11-AS  221883 HOXA11-AS na na HOXA11-AS-miR-205-5p-FOXM1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33261854 J Surg Res 2021 LncRNA HOXA11-AS Aggravates Keloid Progression by the Regulation of HOXA11-AS-miR-205-5p-FOXM1 Pathway Xiaoguang Su; Yaohui Ma; Qing Wang; Yanjun Gao FOXM1; Fibroblasts; HOXA11-AS; Keloid; miR-205-5p. China
33389493 biomarker na LncRNA H19 283120 H19 na na miR-769-5p/EIF3A  driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33389493 Mol Cell Biochem 2021 LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway Lingang Xu; Nan Sun; Guangshuai Li; Linbo Liu EIF3A; Fibroblasts; H19; Keloid; miR-769-5p. China
33405341 biomarker na circRNA hsa_circ_0001320, circCOL5A1 na na na na na na increased RAN-seq https://pubmed.ncbi.nlm.nih.gov/33405341 Dermatol Ther 2021 Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high-throughput sequencing Jing Zhang; Ninghua Liu; Xiufa Wu; Peixuan Wu; Nan Song; Jing Ma circular RNA; epigenetics; high-throughput sequencing; keloid; pathway. China
33131417 biomarker na circRNA Circ_0008450 na na na na Runx3 driver increased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33131417 Cell Cycle 2020 Circ_0008450 downregulates Runx3 to promote the proliferation and epithelial-mesenchymal transition of human keratinized epithelial cells Huaxia Chen; Xiao Xu; Linying Lai; Ran Huo; Minliang Chen  Keloid; Runx3; TGF-β/Smad pathway; circ_0008450. China
33329590 biomarker na na na na na na na Th2, Th1, Th17/Th22, JAK3 na na RAN-seq https://pubmed.ncbi.nlm.nih.gov/33329590 Front Immunol 2020 RNA Sequencing Keloid Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and JAK3-Skewing Jianni Wu; Ester Del Duca; Michael Espino; Alyssa Gontzes; Inna Cueto; Ning Zhang; Yeriel D Estrada; Ana B Pavel; James G Krueger; Emma Guttman-Yassky JAK3; RNA-seq; Th2; immune; inflammation; keloids. USA
33203788 biomarker na lncRNA DLEU2 8847 DLEU2 na na hsa-miR-30a-5p/hsa-miR-30b-5p na increased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/33203788 Aging (Albany NY) 2020 Secondary data mining of GEO database for long non-coding RNA and Competing endogenous RNA network in keloid-prone individuals Yu Deng; Yangbin Xu; Shuqia Xu; Yujing Zhang; Bing Han; Zheng Liu; Xiangxia Liu; Zhaowei Zhu  GEO database; keloid-prone; lncRNA. China
33236602 biomarker na protein Smad7 4092 SMAD7 na na Epithelial-Mesenchymal Transition suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33236602 Sichuan Da Xue Xue Bao Yi Xue Ban 2020 [Effects of Regulating Smad7 Gene on Epithelial-Mesenchymal Transition in Keloid Keratinocyte] Xiao-Fan Zhou; Ya-Nan Zhao; Min-Qin Xiao; Hong Xiao; Yin Liu  Epithelial-mesenchymal transition; Keloid; Smad7. China
32315657 biomarker na protein HIF-1α 3091 HIF1A na na Collagen Production suppressor na na https://pubmed.ncbi.nlm.nih.gov/32315657 J Invest Dermatol 2020 Hypoxia and HIF-1α Regulate Collagen Production in Keloids Yuanyuan Kang; Mi Ryung Roh; Suvi Rajadurai; Anpuchchelvi Rajadurai; Raj Kumar; Ching-Ni Njauw; Zhenlong Zheng; Hensin Tsao na USA
31930556 biomarker na pathway lncRNA-H19/miR-29a na na na na COL1A1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31930556 J Cell Biochem 2020 lncRNA-H19/miR-29a axis affected the viability and apoptosis of keloid fibroblasts through acting upon COL1A1 signaling Zhi Wang; Cheng Feng; Kexin Song; Zheng Qi; Weiqing Huang; Youbin Wang  COL1A1; cell invasion; cell migration; cell proliferation; fibroblasts; keloid; lncRNA H19; miR-29a. China
33150188 biomarker na protein CD26 1803 DPP4 na na PI3K/AKT/mTOR  driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33150188 Burns Trauma 2020 CD26 upregulates proliferation and invasion in keloid fibroblasts through an IGF-1-induced PI3K/AKT/mTOR pathway Yu Xin; Peiru Min; Heng Xu; Zheng Zhang; Yan Zhang; Yixin Zhang  CD26; Fibroblast; IGF-1; Invasion; Keloids; PI3K/AKT/mTOR signalling pathway; Proliferation. China
33126764 biomarker na protein Notch1 4851 NOTCH1 na na NLRP3 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33126764 Int J Mol Sci 2020 Contribution of Autophagy-Notch1-Mediated NLRP3 Inflammasome Activation to Chronic Inflammation and Fibrosis in Keloid Fibroblasts Seongju Lee; Sun Kyeon Kim; Hyungsun Park; Yu Jin Lee; Song Hee Park; Kyung Jae Lee; Dong Geon Lee; Hoon Kang; Jung Eun Kim Autophagy; Inflammasome; Keloid; Notch. South Korea
33817252 biomarker na miRNA MiR-4328  100422932 MIR4328 na na BCL2 suppressor decreased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/33817252 Open Life Sci 2020 MiR-4328 inhibits proliferation, metastasis and induces apoptosis in keloid fibroblasts by targeting BCL2 expression Hongmei Tang; Qi Chen; Wenyuan Yu; Tianlan Zhao  BCL2; apoptosis; keloid; metastasis; miR-4328; proliferation. China
32782509 biomarker na circRNA circ_101238 na na na na miR-138-5p/CDK6 driver increased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32782509 Exp Ther Med 2020 Effects of the circ_101238/miR-138-5p/CDK6 axis on proliferation and apoptosis keloid fibroblasts Dan Yang; Mingjin Li; Na Du apoptosis; circular RNA_101238; cyclin-dependent kinase 6; fibroblast; keloid; micoRNA-138-5p; proliferation. China
32941122 biomarker na protein Nonmuscle Myosin II 4627 MYH9 blebbistatin na TGF-β driver increased IF https://pubmed.ncbi.nlm.nih.gov/32941122 Adv Wound Care (New Rochelle) 2020 Nonmuscle Myosin II Activation Regulates Cell Proliferation, Cell Contraction, and Myofibroblast Differentiation in Keloid-Derived Fibroblasts Ying-Yi Lu; Cheng-Chieh Fang; Chien-Hui Hong; Chieh-Hsin Wu; Yu-Hung Lin; Kee-Lung Chang; Chih-Hung Lee TGF-β; keloids; myofibroblast; nonmuscle myosin II. China
32943899 biomarker na cell Neuronal Precursor Cell na na na na NEDD4 driver na Vss https://pubmed.ncbi.nlm.nih.gov/32943899 Clin Cosmet Investig Dermatol 2020 Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population Azza G A Farag; Hesham N Khaled; Mostafa A Hammam; Mustafa Elsayed Elshaib; Nermin Reda Tayel; Sahar Elsoudy Ibrahim Hommos; Eman Masoud Abd El Gayed NEDD4; gene polymorphism; keloid. Egypt
32474020 biomarker na pathway Sumoylation na na na na TGF-β/SMAD, HIF-1 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/32474020 Life Sci 2020 Sumoylation enhances the activity of the TGF-β/SMAD and HIF-1 signaling pathways in keloids Xiaohu Lin; Yuming Wang; Yan Jiang; Mingyuan Xu; Qianqian Pang; Jiaqi Sun; Yijia Yu; Zeren Shen; Rui Lei; Jinghong Xu HIF-1α; Hypoxia; Keloid; SUMO1; SUMO1-RanGAP1 complex; Sumoylation; TGF-β/SMAD signaling pathway. China
32754856 biomarker na miRNA MiR-506-3p 574511 MIR506 na na Beclin-1 driver decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32754856 In Vitro Cell Dev Biol Anim 2020 MiR-506-3p regulates autophagy and proliferation in post-burn skin fibroblasts through post-transcriptionally suppressing Beclin-1 expression Min Shi; Xiaoming Zong; Lei Chen; Xiaobo Guo; Xinqiang Ding Autophagy; Beclin-1; Dermal fibroblasts; Thermal injury; miR-506-3p. China
32376266 biomarker na protein TM4SF1 4071 TM4SF1 na na AKT/ERK driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/32376266 Life Sci 2020 TM4SF1 involves in miR-1-3p/miR-214-5p-mediated inhibition of the migration and proliferation in keloid by regulating AKT/ERK signaling Mingyuan Xu; Jiaqi Sun; Yijia Yu; Qianqian Pang; Xiaohu Lin; May Barakat; Rui Lei; Jinghong Xu Keloid; Transmembrane 4 L six family member 1; miR-1-3p; miR-214-5p; microRNA. China
32205184 biomarker na miRNA miR-133a-3p 406922 MIR133A1 na na TGF-β/Smad2 suppressor decreased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32205184 Mol Cell Probes 2020 Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-β/Smad2 pathway Yong Huang; Yuting Wang; Lixin Lin; Peng Wang; Lei Jiang; Jian Liu; Xueming Wang Interference regulator 5; Keloid; TGF-β/Smad2; miR-133a-3p. China
31954164 biomarker na protein Syndecan-1 100519770 SDC1 na na TGF-β1/Smad, MAPK driver increased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31954164 Life Sci 2020 Syndecan-1 regulates extracellular matrix expression in keloid fibroblasts via TGF-β1/Smad and MAPK signaling pathways Jing Cui; Shan Jin; Chenglong Jin; Zhehu Jin Keloid; MAPK signaling pathway; Syndecan-1; TGF-β1/Smad. China
32317186 biomarker na protein fibronectin 2335 FN1 na na TGF-β1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32317186 Biochem Biophys Res Commun 2020 Knockdown of fibronectin extra domain B suppresses TGF-β1-mediated cell proliferation and collagen deposition in keloid fibroblasts via AKT/ERK signaling pathway Jingbo Cui; Zhouna Li; Chenglong Jin; Zhehu Jin ERK/AKT signaling pathway; Extra domain B; Fibronectin; Keloid; TGF-β1/smad signaling pathway. China
32495824 biomarker na lncRNA CACNA1G-AS1 253962 CACNA1G-AS1 na na miR-205 driver increased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32495824 Biosci Rep 2020 Long non-coding RNA CACNA1G-AS1 promotes proliferation and invasion and inhibits apoptosis by regulating expression of miR-205 in human keloid fibroblasts Xu Zhao; Xiang Jie; Ya-Kun Gao; Bing Nie; Hua Jiang  CACNA1G-AS1; apoptosis; invasion; keloid fibroblasts; miR-205; proliferation. China
31904383 biomarker na circRNA hsa _ circRNA _ 0002198 na na na na na na increased RAN-seq, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31904383 Exp Cell Res 2020 Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts Zhibin Zhang; Kaihui Yu; Ougen Liu; Yifeng Xiong; Xinyue Yang; Shuhua Wang; Shulan Zhang; Yueying Feng; Yating Peng Bioinformatics; Circular RNAs; Dermal fibroblasts; Expression profile; Keloid; MicroRNA. China
32216491 biomarker na miRNA MicroRNA-21 406991 MIR21 Galla chinensis ointment na p-Akt, p-mTOR driver decreased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/32216491 J Int Med Res 2020 MicroRNA-21 may be involved in the therapeutic effects of Galla chinensis ointment on keloid Zhiming Tang; Jicun Ding; Xiaoxiang Zhai; Mengqing Jing; Zhiqiang Guan; Yongcong Li Galla chinensis ointment; PTEN; fibroblast; keloid; mTOR; miR-21. China
32309369 biomarker na na ceRNAs EGFR/miR-370-3p/lnc-GLB1L-1
ITGB5/miR-204/lnc-CASP9-3 		na na na na na na increased RNA-seq, miRNA-seq https://pubmed.ncbi.nlm.nih.gov/32309369 Ann Transl Med 2020 Identification and analysis of dysregulated lncRNA and associated ceRNA in the pathogenesis of keloid Xilei Duan; Yuemeng Wu; Zheng Zhang; Zhong Lu  Keloid; RNA sequence; competing endogenous RNA; lncRNA. China
32182995 biomarker na protein Chondroitin Sulfate na na na na AKT driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32182995 Int J Mol Sci 2020 Chondroitin Sulfate Promotes the Proliferation of Keloid Fibroblasts Through Activation of the Integrin and Protein Kinase B Pathways Yasuhiro Katayama; Motoko Naitoh; Hiroshi Kubota; Satoko Yamawaki; Rino Aya; Toshihiro Ishiko; Naoki Morimoto  PI3K/Akt pathway; chondroitin sulfate; fibroblast; integrin; keloids. Japan
31814061 biomarker na protein IL-17 3605 IL17A na na STAT3 driver increased qRT-PCR, IF https://pubmed.ncbi.nlm.nih.gov/31814061 Inflammation 2020 IL-17 Induced Stromal Cell-Derived Factor-1 and Profibrotic Factor in Keloid-Derived Skin Fibroblasts via the STAT3 Pathway Seon-Yeong Lee; Eun Kyung Kim; Hyun Beom Seo; Jeong Won Choi; Jin Hee Yoo; Kyoung Ah Jung; Da-Som Kim; Seung Cheon Yang; Soo Jin Moon; Jung Ho Lee; Mi-La Cho IL-17; SDF-1; STAT3; fibroblast; keloid. South Korea
31246819 biomarker na na Mechanical Stress, Strain, Stiffness na na na na Caveolin-1/ROCK driver increased IHC https://pubmed.ncbi.nlm.nih.gov/31246819 Plast Reconstr Surg 2019 The Interplay of Mechanical Stress, Strain, and Stiffness at the Keloid Periphery Correlates with Increased Caveolin-1/ROCK Signaling and Scar Progression Teruyuki Dohi; Jagannath Padmanabhan; Satoshi Akaishi; Peter A Than; Masao Terashima; Noriko N Matsumoto; Rei Ogawa; Geoffrey C Gurtner  na USA
31173246 biomarker na protein USP4 7375 USP4 na na TGF‑β/Smad driver increased IP, IHC https://pubmed.ncbi.nlm.nih.gov/31173246 Mol Med Rep 2019 Inhibition of USP4 attenuates pathological scarring by downregulation of the TGF‑β/Smad signaling pathway Jie Zhang; Sijia Na; Shuting Pan; Sang Long; Yuqi Xin; Qingkun Jiang; Zhongwei Lai; Junfeng Yan; Zhongyi Cao  na China
30940456 biomarker na protein TRAF4 9618 TRAF4 na na USP10 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/30940456 J Invest Dermatol 2019 TRAF4 Promotes Fibroblast Proliferation in Keloids by Destabilizing p53 via Interacting with the Deubiquitinase USP10 Cheng-Cheng Deng; Ding-Heng Zhu; Yong-Jun Chen; Tao-Yuan Huang; Yang Peng; Si-Ya Liu; Ping Lu; Yao-Hua Xue; Ying-Ping Xu; Bin Yang; Zhili Rong na China
31288014 biomarker na protein FOXM1 2305 FOXM1 na na TGF-β1/Smad driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/31288014 Life Sci 2019 Knockdown of FOXM1 inhibits activation of keloid fibroblasts and extracellular matrix production via inhibition of TGF-β1/Smad pathway Yangang Zhang; Chuantao Cheng; Shuang Wang; Meifeng Xu; Dewu Zhang; Weihui Zeng Extracellular matrix ; Fibroblasts; Fibrosis; FOXM1; Keloids; TGF-β1/Smad signaling pathway. China
31066603 biomarker na protein Periostin 10631 POSTN na na RhoA/ROCK driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/31066603 J Plast Surg Hand Surg 2019 Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation Daisuke Maeda; Tateki Kubo; Koichiro Kiya; Kenichiro Kawai; Shinsuke Matsuzaki; Daichi Kobayashi; Toshihiro Fujiwara; Taiichi Katayama; Ko Hosokawa  IL-4/IL-13; Keloid; TGF-β1; hypertrophic scar; periostin. Japan
31430452 biomarker na miRNA MiR-152-3p 406943 MIR152 na na FOXF1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31430452 Life Sci 2019 MiR-152-3p regulates cell proliferation, invasion and extracellular matrix expression through by targeting FOXF1 in keloid fibroblasts Rui Wang; Zhuanli Bai; Xiulin Wen; Huicong Du; Lin Zhou; Zhishui Tang; Zhuangqun Yang; Wei Ma Cell proliferation; Extracellular matrix; FOXF1; Invasion; Keloid fibroblasts; miR-152-3p. China
31696499 biomarker na protein IL-10 3586 IL10 na na TGF-β/Smad  suppressor na cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31696499 Eur Rev Med Pharmacol Sci 2019 Therapeutic effect of interleukin-10 in keloid fibroblasts by suppression of TGF-β/Smad pathway C-K Shi; Y-P Zhao, P Ge, G-B Huang na China
31184708 biomarker na miRNA MiR-21 100314000 Mir21 na na TGF-β/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31184708 J Burn Care Res 2019 MiR-21 Regulates Keloid Formation by Downregulating Smad7 via the TGF-β/Smad Signaling Pathway Junliang Wu; Lu Fang; Ying Cen; Yong Qing; Junjie Chen; Zhengyong Li  MiR-21; Keloid; TGF-β/Smad; Smad7; Fibrosis China
31451218 biomarker na protein STAT3 6774 STAT3 na na NEDD4 na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31451218 Biochem Biophys Res Commun 2019 STAT3 operates as a novel transcription factor that regulates NEDD4 in Keloid Yu Wang; Bo Yuan; Liang Qiao; Huizhong Yang; Xuechuan Li Keloid; NEDD4; STAT3; Transcription factor; p-STAT3. China
31385019 biomarker na protein S1P 8720 MBTPS1 na na MAPK driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31385019 Arch Dermatol Res 2019 Association between sphingosine-1-phosphate-induced signal transduction via mitogen-activated protein kinase pathways and keloid formation Seung Hyo Jung; Yu Kwan Song; Hong Chung; Hyun Myung Ko; Sung Hoon Lee; Dong In Jo; Bokyung Kim; Dong Hee Lee; Soon Heum Kim Fibroblasts; Keloid scars; Mitogen-activated protein kinase; Signal transduction; Sphingosine-1-phosphate. South Korea
31411918 biomarker na lncRNA HOXA11-AS 221883 HOXA11-AS na na Smad5 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/31411918 Am J Physiol Cell Physiol 2019 Long non-coding RNA HOXA11-AS induces type I collagen synthesis to stimulate keloid formation via sponging miR-124-3p and activation of Smad5 signaling Jun Jin; Hong-Feng Zhai; Zhen-Hua Jia; Xiao-Hua Luo  Smad5; keloid formation; lncRNA HOXA11-AS; miR-124-3p; type I collagen. China
31645185 biomarker na protein HIF-1α  3091 HIF1A na na TGF-β/Smad, TLR4/MyD88/NF-κB driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31645185 Cell Cycle 2019 HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways Rui Lei; Jian Li; Feng Liu; Weihan Li; Shizhen Zhang; Yang Wang; Xi Chu; Jinghong Xu  HIF-1α; NF-κB; TGF-β/Smad; TLR4; fibroblasts; keloid. China
31764649 biomarker na protein Cathepsins B, D, G 6387 CXCL12 na na na driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31764649 Plast Reconstr Surg 2019 Expression of Cathepsins B, D, and G by the Embryonic Stem Cell-Like Population within Human Keloid Tissues and Keloid-Derived Primary Cell Lines Claudia Paterson; Valerie M Y Lee; Helen D Brasch; Bede van Schaijik; Reginald Marsh; Swee T Tan; Tinte Itinteang  na New Zealand
31612410 biomarker na circRNA hsa_circ_0057452, hsa_circ_0007482, hsa_circ_0020792, hsa_circ_0057342, hsa_circ_0043688 na na na na miRNA-29a, miRNA-23a-5p, miRNA-1976 na increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/31612410 Mol Biol Rep 2020 The integrative regulatory network of circRNA and microRNA in keloid scarring Jingpei Shi; Shuluan Yao; Pan Chen; Yuan Yang; Mengjiao Qian; Yi Han; Nan Wang; Yu Zhao; Yongjing He; Lechun Lyu; Di Lu Circular RNA; Keloid; Microarray; microRNA. China
31878829 biomarker na lncRNA HOXA11-AS 221883 HOXA11-AS na na miR-124-3p/TGFβR1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31878829 Cell Cycle 2020 Long non-coding RNA HOXA11-AS accelerates the progression of keloid formation via miR-124-3p/TGFβR1 axis Jun Jin; Zhen-Hua Jia; Xiao-Hua Luo; Hong-Feng Zhai  Keloid formation; TGFβ receptor type I; lncRNA HOXA11-AS; miR-124-3p. China
32345773 biomarker na miRNA miR-4417 na na na na cyclind1 suppressor decreased cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32345773 J Biosci 2020 miR-4417 suppresses keloid fibrosis growth by inhibiting CyclinD1 Pei Liu; Yaotian Hu, Lin Xia, Min DU, Zhensheng Hu . Apoptosis; CyclinD1; fibrosis; keloid; miR-4417 China
31624676 biomarker na noncoding RNA miRNA, lncRNA. circRNA na na na na na na na RNA-SEQ, qRT-PCR https://pubmed.ncbi.nlm.nih.gov/31624676 Plast Reconstr Surg Glob Open 2019 Expression Profiles of lncRNAs and circRNAs in Keloid Jie Wang; Hao Wu; Zhibo Xiao; Xiaoqun Dong na China
30638178 biomarker na miRNA MicroRNA-152-5p 406943 MIR152 na na Smad3 suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30638178 BMB Rep 2019 MicroRNA-152-5p inhibits proliferation and migration and promotes apoptosis by regulating expression of Smad3 in human keloid fibroblasts Qianqian Pang; Yuming Wang; Mingyuan Xu; Jiachao Xu; Shengquan Xu; Yichen Shen; Jinghong Xu; Rui Lei  na China
29863417 biomarker na mRNA VEGFC, TNC 7424, 3371 VEGFC, TNC na na na na na bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/29863417 J Dermatolog Treat 2019 Gene expression profiling analysis: the effect of hydrocortisone on keloid fibroblasts by bioinformatics Lianbo Zhang; Haiyan Qin; Zhuoxia Wu; Wanying Chen; Guang Zhang Differentially expression gene; bioinformatics analysis; molecular mechanism. China
30784061 biomarker na protein Parkin 5071 PRKN na na TGF-β/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30784061 J Cell Physiol 2019 Inactivating the ubiquitin ligase Parkin suppresses cell proliferation and induces apoptosis in human keloids Rui Lei; Jian Shen; Shizhen Zhang; Aiyu Liu; Xi Chen; Yang Wang; Jiaqi Sun; Siya Dai; Jinghong Xu  HIF-1α; Parkin; keloid; keloid fibroblasts; metformin. China
30765798 biomarker na protein Oncostatin M 5008 OSM na na TGFβ1 suppressor increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/30765798 Sci Rep 2019 Oncostatin M exerts a protective effect against excessive scarring by counteracting the inductive effect of TGFβ1 on fibrosis markers Vincent Huguier; Jean-Philippe Giot; Marie Simonneau; Pierre Levillain; Sandrine Charreau; Martine Garcia; Jean-François Jégou; Charles Bodet; Franck Morel; Jean-Claude Lecron; Laure Favot na France
30668826 biomarker na miRNA miR-188-5p 406964 MIR188 na na PI3K/Akt/MMP-2/9 suppressor decreased miRNA array, qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/30668826 Acta Biochim Biophys Sin (Shanghai) 2019 miR-188-5p regulates proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloids Wenyan Zhu; Xiaoyan Wu; Bo Yang; Xiaodong Yao; Xiaomei Cui; Pan Xu; Xiaodong Chen  MMP; PI3K/Akt; invasion; keloid; miR-188-5p. China
30471838 biomarker na protein NEDD4  4734 NEDD4 na na NF-κB/STAT3 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/30471838 J Invest Dermatol 2019 A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis Alexander G Marneros MMP; PI3K/Akt; invasion; keloid; miR-188-5p. USA
30651862 biomarker na miRNA miR-96 407053 MIR96 na na Smad7 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/30651862 Exp Ther Med 2019 miR-96 promotes collagen deposition in keloids by targeting Smad7 Li Chao; Zhu Hua-Yu, Bai Wen-Dong, Song Mei; Xiao Bin; Hu Da-Hai, Liu Yi   benign tumor; keloid; microRNA-96; mothers against decapentaplegic homolog 7; skin fibroblasts. China
30372829 biomarker na miRNA MiR-203 406986 MIR203A na na EGR1,FGF2 driver decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30372829 Biomed Pharmacother 2018 MiR-203 regulates keloid fibroblast proliferation, invasion, and extracellular matrix expression by targeting EGR1 and FGF2 Kai Shi; Xiang Qiu; Wei Zheng; Dongmei Yan; Weihai Peng EGR1; FGF2; Keloid; Keloid fibroblast; miR-203. China
30662665 biomarker radiation drug na na na quercetin DB04216 PI3K/Akt sensitive na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30662665 Am J Transl Res 2018 Sensitization of keloid fibroblasts by quercetin through the PI3K/Akt pathway is dependent on regulation of HIF-1α Lou-Bin Si; Ming-Zi Zhang; Qin Han; Jian-Nan Huang; Xiao Long; Fei Long; Robert Chun-Hua Zhao; Jiu-Zuo Huang; Zhi-Fei Liu; Ru Zhao; Hai-Lin Zhang; Xiao-Jun Wang  Keloid; hypoxia-inducible factor 1; phosphatidylinositol-3-kinase/Akt pathway; quercetin; radioresistance. China
30569148 biomarker na protein TSG-6 7130 TNFAIP6 na na apoptosis suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30569148 Mol Med Rep 2019 In vitro analysis of the role of tumor necrosis factor‑stimulated gene‑6 in keloid Xinyi Li; Zhao Chen; Xiaojing Li; Hui Wang  tumor  necrosis  factor-stimulated  gene-6; apoptosis; proliferation; keloid; fibrosis. China
30273597 biomarker na protein NEDD4  4734 NEDD4 na na NF-κB, STAT3 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/30273597 J Invest Dermatol 2019 NEDD4 Is Involved in Inflammation Development during Keloid Formation Munezumi Fujita; Yuhei Yamamoto; Jing-Jing Jiang; Toru Atsumi; Yuki Tanaka; Takuto Ohki; Naoki Murao; Emi Funayama; Toshihiko Hayashi; Masayuki Osawa; Taku Maeda; Daisuke Kamimura; Masaaki Murakami na Japan
30146129 biomarker na protein TGF-β, IL-22, ARG-1 7040, 50616, 383 TGFB1, IL22, ARG1 na na na na increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/30146129 Immunobiology 2018 High in situ mRNA levels of IL-22, TFG-β, and ARG-1 in keloid scars Luciana Rodrigues da Cunha Colombo Tiveron; Isabela Rios da Silva; Marcos Vinicius da Silva; Alberto Borges Peixoto; Denise Bertulucci Rocha Rodrigues; Virmondes Rodrigues Jr Cytokines; Keloid scar; Wound healing. Brazil
30604399 biomarker na miRNA miRNA-21, miRNA-141-3p, miRNA-181a, miRNA-205 na na na na PI3K/Akt na increased bioinformatic approaches https://pubmed.ncbi.nlm.nih.gov/30604399 Mol Diagn Ther 2019 Integrated Interaction Network of MicroRNA Target Genes in Keloid Scarring Lechun Lyu; Yu Zhao; Hongquan Lu; Zijie Liu; Jiazhi Guo; Di Lu; Xiang Li na China
30543583 biomarker na lncRNA AC073257.2  na na na na GLI2 na increased RNA-SEQ, qRT-PCR https://pubmed.ncbi.nlm.nih.gov/30543583 Med Sci Monit 2018 Detection and Analysis of the Hedgehog Signaling Pathway-Related Long Non-Coding RNA (lncRNA) Expression Profiles in Keloid Heping Huang; Shangfeng Fu; Dewu Liu  na China
30519378 biomarker na protein Angiotensin II, AT1 receptor 183, 185 AGT, AGTR1 na na na driver increased ELISA https://pubmed.ncbi.nlm.nih.gov/30519378 J Clin Aesthet Dermatol 2018 Detection of Angiotensin II and AT1 Receptor Concentrations in Keloid and Hypertrophic Scar Feizollah Niazi; Seyed Hassan Hooshyar; Keshvad Hedayatyanfard; Seyed Ali Ziai; Farideh Doroodgar; Sana Niazi; Behnam Habibi; Ali Asadirad AT1; Angiotensin II; ELISA; hypertrophic scar; keloid. Iran
30341526 biomarker na protein Cthrc1 115908 CTHRC1 na na TGF-β/Smad suppressor increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/30341526 Curr Med Sci 2018 Increased Cthrc1 Activates Normal Fibroblasts and Suppresses Keloid Fibroblasts by Inhibiting TGF-β/Smad Signal Pathway and Modulating YAP Subcellular Location Meng-Jie Zhao; Si-Yuan Chen; Xiao-Ying Qu; Bilal Abdul-Fattah; Ting Lai; Meng Xie; Shi-di Wu; You-Wen Zhou; Chang-Zheng Huang Collagen triple helix repeat containing protein 1; TGF-β; YAP; keloid. China
30030902 biomarker na miRNA miRNA-199a-5p, miRNA-21-5p, miRNA-214-5p, miRNA-424-5p, miRNA-205-5p na na na na na na increased miRNA microarray, qRT-PCR https://pubmed.ncbi.nlm.nih.gov/30030902 J Cosmet Dermatol 2018 Identification and integrated analysis of microRNA expression profiles in keloid Lianmei Zhong; Ligong Bian; Jing Lyu; Huiyan Jin; Zijie Liu; Lechun Lyu; Di Lu  integrated analysis; keloid; microRNA; microarray. China
29527928 biomarker na miRNA MiR-21 406991 MIR21 na na apoptosis driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29527928 Biochem Cell Biol 2018 MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and the mitochondria-mediated apoptotic signaling pathway via targeting FasL Ying Liu; Lihong Ren; Wenjing Liu; Zhibo Xiao FasL; apoptose; apoptosis; chéloïde; keloid; miR-21; mitochondria-mediated apoptotic signaling pathway; voie de signalisation mitochondriale de l’apoptose. China
30212944 biomarker na protein Wnt2 7472 WNT2 na na na driver na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30212944 Medicine (Baltimore) 2018 Wnt2 knock down by RNAi inhibits the proliferation of in vitro-cultured human keloid fibroblasts Yumei Cai; Weiqun Yang, Mingmeng Pan, Chaoyang Wang, Wenyi Wu, Shize Zhu fibroblast, GSK-3b, Keloid, RNAi, Wnt2 China
29846215 biomarker na protein s100a4 6275 S100A4 na na TGF-β/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29846215 Ann Plast Surg 2018 Calcimycin Suppresses S100A4 Expression and Inhibits the Stimulatory Effect of Transforming Growth Factor β1 on Keloid Fibroblasts Yi-Xuan Zhao; Chia-Kang Ho, Yun Xie, Ya-Hong Chen, Hai-Zhou Li, Guo-You Zhang, Qing-Feng Li calcimycin, fibroblasts, keloid, S100A4, TGF-β1 China
29845237 biomarker na miRNA miR‑637 693222 MIR637 na na Smad3 suppressor increased miRNA microarray, qRT-PCR https://pubmed.ncbi.nlm.nih.gov/29845237 Mol Med Rep 2018 Downregulation of miR‑637 promotes proliferation and metastasis by targeting Smad3 in keloids Ye Zhang; Bingyu Guo; Qiang Hui; Wei Li; Peng Chang; Kai Tao  smad3, keloid, miR-637, proliferation, metastasis China
29963160 biomarker na lncRNA CACNA1G-AS1 253962 CACNA1G-AS1 na na calcium channel protein suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29963160 Oncol Lett 2018 Long non-coding RNA CACNA1G-AS1 promotes calcium channel protein expression and positively affects human keloid fibroblast migration Ye Li; Xuebing Liang; Peng Wang; Xiao Long; Xiaojun Wang; Zhiqiang Meng CACNA1G-AS1; calcium channel; fibroblast; keloid; long noncoding RNA. China
29849053 biomarker na protein HMGB1 3146 HMGB1 na na TGF-β/Smad driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29849053 Sci Rep 2018 Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues Won Jai Lee; Seung Yong Song; Hyun Roh; Hyo Min Ahn; Youjin Na; Jihee Kim; Ju Hee Lee; Chae Ok Yun na South Korea
29669739 biomarker na na Tissue stiffening na na na na EGF driver na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29669739 J Cell Sci 2018 Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling Fiona N Kenny; Zoe Drymoussi; Robin Delaine-Smith; Alexander P Kao; Ana C Laly; Martin M Knight; Michael P Philpott; John T Connelly EGF; Epidermis; Keloid; Keratinocyte; Mechanotransduction; Proliferation. UK
29695130 biomarker na protein HtrA1 5654 HTRA1 na na na driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29695130 Int J Mol Sci 2018 HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development Satoko Yamawaki; Motoko Naitoh; Hiroshi Kubota; Rino Aya; Yasuhiro Katayama; Toshihiro Ishiko; Taku Tamura; Katsuhiro Yoshikawa; Tatsuki Enoshiri; Mika Ikeda 0; Shigehiko Suzuki  HtrA1; fibroproliferative disorder; inflammation; keloids. Japan
31938293 biomarker na miRNA miR-217 406999 MIR217 na na Fibronectin suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31938293 Int J Clin Exp Pathol 2018 A novel regulatory function for miR-217 targetedly suppressing fibronectin expression in keloid fibrogenesis Wei Wu; Feng Xie; Yi Zhang; Xiuxia Wang; Lingling Xia; Xiaoli Wu; Zhen Gao  MiRNA-217; fibroblasts; fibronectin; keloid fibrogenesis. China
29455276 biomarker na protein SFRP1 6422 SFRP1 na na Wnt/β-catenin suppressor decreased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29455276 J Mol Histol 2018 Methylation of secreted frizzled-related protein 1 (SFRP1) promoter downregulates Wnt/β-catenin activity in keloids Jiaqi Liu; Huayu Zhu; Hongtao Wang; Jun Li; Fu Han; Yang Liu; Wanfu Zhang; Ting He; Na Li; Zhao Zheng; Dahai Hu Hypermethylation; Keloid; SFRP1; Wnt/β-catenin. China
29194570 biomarker na cell CD45RO+ memory T cells  na na na na TNF-α suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29194570 Br J Dermatol 2018 Characterization of CD45RO+ memory T lymphocytes in keloid disease Z Chen; L Zhou; T Won; Z Gao; X Wu; L Lu na China
29286129 biomarker na protein elF3a 8661 EIF3A na na TGF‑β1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29286129 Mol Med Rep 2018 Knockdown of elF3a inhibits TGF‑β1‑induced extracellular matrix protein expression in keloid fibroblasts Tianyu Li; Junxiang Zhao  eukaryotic translation initiation factor 3a; TGF-β1; keloid fibroblasts; extracellular matrix. China
29204684 biomarker na gene CDC2L1 984 CDK11B na na CDk11p58 suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29204684 Arch Dermatol Res 2018 DNA methylation of the CDC2L1 gene promoter region decreases the expression of the CDK11p58 protein and reduces apoptosis in keloid fibroblasts Gang Zhang; QiaoYu Guan; Guizong Chen; Fang Qian; Jie Liang 5-Aza-2′deoxycytidine; Apoptosis; CDC2L1; CDK11p58; Keloids. China
29029852 biomarker na cell adipose tissue-derived stem cells na na na na apoptosis suppressor na Brdu proliferation assay, a validated co-culture migration assay, flow cytometry https://pubmed.ncbi.nlm.nih.gov/29029852 Burns 2018 Human adipose tissue-derived stem cells inhibit the activity of keloid fibroblasts and fibrosis in a keloid model by paracrine signaling Jianlan Liu; Jie Ren; Lina Su; Shimeng Cheng; Jing Zhou; Xiaolu Ye; Yabin Dong; Silei Sun; Fazhi Qi; Zhifei Liu; Jonathon Pleat; Hongjun Zhai; Ningwen Zhu Fibrosis; Keloid; Mesenchymal stem cells; Model; Proliferation. China
29509234 biomarker na protein β-catenin 1499 CTNNB1 na na apoptosis driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29509234 Eur Rev Med Pharmacol Sci 2018 The mechanisms of β-catenin on keloid fibroblast cells proliferation and apoptosis Z-Y Chen; X-F Yu, J-Q Huang, D-L Li na China
29467010 biomarker na cell adipose tissue-derived stem cells na na na na CD31+, CD34+ suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29467010 Stem Cell Res Ther 2018 Human adipose-derived stem cells inhibit bioactivity of keloid fibroblasts Xiuxia Wang; Yan Ma; Zhen Gao; Jun Yang Adipose-derived stem cells; Conditioned medium; Keloid fibroblasts. China
29412803 biomarker na protein HTRA1 5654 HTRA1 na na TGF‑β1 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29412803 Cell Mol Biol (Noisy-le-grand) 2018 High temperature requirement factor A1 (HTRA1) regulates the activation of latent TGF-β1 in keloid fibroblasts Shi-Feng Jin; Yu-Xin Wang; Nan Xu; Qiang Sun; Chen-Chao Wang; Meng-Zhu Lv; Xu Sun; Shu Guo  HTRA1; Pathological scar; Smad2.; TGF-β. China
29423039 biomarker na protein HIF-1α 3091 HIF1A na na TGF‑β1 driver increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29423039 Oncotarget 2017 Hypoxia-inducible factor-1α activates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts Xu Mingyuan; Pang Qianqian; Xu Shengquan; Ye Chenyi; Lei Rui; Shen Yichen; Xu Jinghong  collagen; hypoxia; hypoxia-Inducible factor-1α; keloid; TGFr-β1/Smad. China
28899682 biomarker na protein CAV1 857 CAV1 na na RUNX2 suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28899682 J Invest Dermatol 2018 Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts Chao-Kai Hsu; Hsi-Hui Lin; Hans I Harn; Rei Ogawa; Yang-Kao Wang; Yen-Ting Ho; Wan-Rung Chen; Yi-Chao Lee; Julia Yu-Yun Lee; Shyh-Jou Shieh; Chao-Min Cheng 0; John A McGrath; Ming-Jer Tang keloid/caveolin-1/RUNX2/mechanobiology/fibrosis China
29283384 biomarker na protein HMGB1 3146 HMGB1 na na RAGE-MAPK, NF-κB driver decreased WB https://pubmed.ncbi.nlm.nih.gov/29283384 Int J Mol Sci 2017 High-Mobility Group Box 1 Mediates Fibroblast Activity via RAGE-MAPK and NF-κB Signaling in Keloid Scar Formation Jihee Kim; Jong-Chul Park; Mi Hee Lee; Chae Eun Yang; Ju Hee Lee; Won Jai Lee HMGB1; fibroblast; hypertrophic scar; keloid. South Korea
29253537 biomarker na cell CD14+ macrophages na na na na CD3+ T cell na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29253537 Exp Cell Res 2018 Macrophages in keloid are potent at promoting the differentiation and function of regulatory T cells Qi Jin; Lai Gui; Feng Niu; Bing Yu; Nicole Lauda; Jianfeng Liu; Xiaoyan Mao; Ying Chen Keloid; Macrophage; Regulatory T cell. China
29050938 biomarker na miRNA miR-1224-5p 100187716 MIR1224 na na TGF-β/Smad3 suppressor decreased miRNA microarray analysis https://pubmed.ncbi.nlm.nih.gov/29050938 Biochem Biophys Res Commun 2018 Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-β1/Smad3 signaling pathway Xiaodong Yao; Xiaomei Cui; Xiaoyan Wu; Pan Xu; Wenyan Zhu; Xiaodong Chen; Tianlan Zhao Fibroblasts; Keloid; Skin tumor; TGF-β1/Smad3; miR-1224-5p. China
29053518 biomarker na protein HIPK2 28996 HIPK2 na na TGF-β/Smad3 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29053518 Ann Plast Surg 2017 Role of Homeodomain-Interacting Protein Kinase 2 in the Pathogenesis of Tissue Fibrosis in Keloid-Derived Keratinocytes Yi-Xuan Zhao; Guo-You Zhang, An-Yuan Wang, Ya-Hong Chen, Da-Mu Lin, Qing-Feng Li keloid, epithelial-mesenchymal transition, homeodomain-interacting protein kinase, TGFr–β1 China
28778755 biomarker na protein vitamin D receptor 7421 VDR na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/28778755 Burns 2017 Abnormal expression of the vitamin D receptor in keloid scars Jennifer M Hahn; Dorothy M Supp Keloid scar; Nuclear hormone receptor; Nuclear localization; Skin pigmentation; Vitamin D; Vitamin D receptor. USA
29190966 biomarker na miRNA MicroRNA-21 406991 MIR21 na na apoptosis suppressor increased WB https://pubmed.ncbi.nlm.nih.gov/29190966 Oncotarget 2017 MicroRNA-21 inhibits mitochondria-mediated apoptosis in keloid Hao Wu; Jie Wang; Hui Ma; Zhibo Xiao; Xiaoqun Dong apoptosis; fibroblasts; keloid; microRNA-21; mitochondria. China
29316036 biomarker na protein IRE1 2081 ERN1 na na na driver increased scar formation https://pubmed.ncbi.nlm.nih.gov/29316036 Wound Repair Regen 2017 Inhibition of IRE1 results in decreased scar formation Tatiana V Boyko; Rakesh Bam; Dadi Jiang; Zhen Wang; Namrata Bhatia; Misha C Tran; Michael T Longaker; Albert C Koong; George P Yang Hypertrophic scar, scar thickness, unfolded protein response, IRE1, Xbp1 USA
28946191 biomarker na protein TMEM88 92162 TMEM88 na na TGF-β1 suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28946191 Biomed Pharmacother 2017 TMEM88 inhibits extracellular matrix expression in keloid fibroblasts Huafei Zhao; Fei Lu; Shuo Cui; Xinying Zhang; Weixin Wang; Enze Si; Zhengjiang Yuan Extracellular matrix; Keloid; TGF-β1; TMEM88. China
28458155 biomarker na protein DKK3 27122 DKK3 na na TGF-β/Smad suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28458155 Biomed Pharmacother 2017 DKK3 regulates cell proliferation, apoptosis and collagen synthesis in keloid fibroblasts via TGF-β1/Smad signaling pathway Yang Li; Hengxin Liu; Yingzi Liang; Pai Peng; Xianjie Ma; Xi Zhang Cell proliferation; Collagen synthesis; DKK3; Keloid fibroblasts; TGF-β1/Smad signaling pathway. China
28720118 biomarker na cell Mesenchymal stem cells na na na na apoptosis suppressor na MTT, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28720118 Stem Cell Res Ther 2017 Inhibiting function of human fetal dermal mesenchymal stem cells on bioactivities of keloid fibroblasts Ya Jiao; Xiao Wang; Jixun Zhang; Yongjun Qi; Hongmin Gong; Duyin Jiang Conditioned medium; Fetal dermal mesenchymal stem cells; Keloid. China
27892645 biomarker na protein ET-1 1906 EDN1 na na RhoA/Rho-kinase driver increased WB https://pubmed.ncbi.nlm.nih.gov/27892645 Exp Dermatol 2017 Endothelial cell-derived endothelin-1 is involved in abnormal scar formation by dermal fibroblasts through RhoA/Rho-kinase pathway Koichiro Kiya; Tateki Kubo; Kenichiro Kawai; Shinsuke Matsuzaki; Daisuke Maeda; Toshihiro Fujiwara; Akimitsu Nishibayashi; Shigeyuki Kanazawa; Kenji Yano; Genki Amano; Taiichi Katayama; Ko Hosokawa  hypertrophic scar; keloid; mechanical stretch; myofibroblasts; α-smooth muscle actin. Japan
28619509 biomarker na miRNA miR-141-3p 406933 MIR141 na na GAB1 suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28619509 Biochem Biophys Res Commun 2017 miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids Jingjuan Feng; Siliang Xue; Qiuyu Pang; Zhen Rang; Fan Cui GAB1; Keloids; Migration; Proliferation; miR-141-3p. China
29088812 biomarker na miRNA microRNA-31 407035 MIR31 na na HIF1AN  suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29088812 Oncotarget 2017 Downregulation of microRNA-31 inhibits proliferation and induces apoptosis by targeting HIF1AN in human keloid Juan Zhang; Dan Xu; Na Li; Yan Li; Yongjing He; Xingbo Hu; Lechun Lyu; Li He  apoptosis; cell cycle; keloid; microRNA-31; proliferation. China
28905881 biomarker na protein ASAH1 427 ASAH1 na na na na variation exome sequencing https://pubmed.ncbi.nlm.nih.gov/28905881 Eur J Hum Genet 2017 Identification of ASAH1 as a susceptibility gene for familial keloids Regie Lyn P Santos-Cortez; Ying Hu; Fanyue Sun; Fairouz Benahmed-Miniuk; Jian Tao; Jitendra K Kanaujiya; Samuel Ademola; Solomon Fadiora; Victoria Odesina; Deborah A Nickerson; Michael J Bamshad; Peter B Olaitan; Odunayo M Oluwatosin; Suzanne M Leal; Ernst J Reichenberger na USA
29021584 biomarker na protein Mortalin 3313 HSPA9 na na apoptosis driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29021584 Sci Rep 2017 Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids Won Jai Lee; Hyo Min Ahn; Youjin Na; Renu Wadhwa; JinWoo Hong; Chae-Ok Yun na South Korea
28454879 biomarker na cell CD26+ cell na na na na na driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28454879 Exp Cell Res 2017 Expansion of CD26 positive fibroblast population promotes keloid progression Yu Xin; Xiangsheng Wang; Ming Zhu; Miao Qu; Melia Bogari; Li Lin; Zin Mar Aung; Wei Chen; Xiaojun Chen; Gang Chai; Yan Zhang CD26; Fibroblasts; Heterogeneity; Keloid. China
28740772 biomarker na protein YAP/TAZ 10413 YAP1 na na hippo na increased IHC https://pubmed.ncbi.nlm.nih.gov/28740772 Plast Reconstr Surg Glob Open 2017 Relationship between Keloid Formation and YAP/TAZ Signaling Noriko Aramaki-Hattori; Keisuke Okabe; Mariko Hamada; Tamae Takato; Kazuo Kishi  na Japan
27882385 biomarker na protein NRG1 3084 NRG1 na na NRG1/ErbB2/Src/PTK2 driver increased microarray analysis https://pubmed.ncbi.nlm.nih.gov/27882385 Acta Derm Venereol 2017 A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling Natalie Jumper; Tom Hodgkinson, Ralf Paus, Ardeshir Bayat keloid disease; laser capture microdissection; neuregulin-1; ErbB2; migration. UK
30603483 biomarker na protein EDIL3 10085 EDIL3 na na na na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30603483 Tissue Eng Regen Med 2017 Epidermal Growth Factor (EGF)-Like Repeats and Discoidin I-Like Domains 3 (EDIL3): A Potential New Therapeutic Tool for the Treatment of Keloid Scars Yeon Hee Ryu; Yoon Jae Lee; Ki-Joo Kim; Su Jin Lee; Yu-Na Han; Jong-Won Rhie Collagen; EDIL3; Keloid scar; Transfection; siRNA. South Korea
28656880 biomarker na protein β-catenin 1499 CTNNB1 na na Wnt2 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28656880 Tumour Biol 2017 Downregulation of β-catenin blocks fibrosis via Wnt2 signaling in human keloid fibroblasts Yumei Cai; Shize Zhu; Weiqun Yang; Mingmeng Pan; Chaoyang Wang; Wenyi Wu Keloid; Wnt2 pathway; cell proliferation; fibroblast; β-catenin. China
28404955 biomarker na lncRNA CACNA1G-AS1, HOXA11-AS, LINC00312, RP11-91I11.1 na na na na Wnt na increased qRT-PCR, lncRNA microarray https://pubmed.ncbi.nlm.nih.gov/28404955 Oncotarget 2017 Identification of skin-related lncRNAs as potential biomarkers that involved in Wnt pathways in keloids Xiao-Jie Sun; Qiang Wang; Baofeng Guo; Xian-Ying Liu; Bing Wang  Wnt pathway; biostatistics; keloid; long noncoding RNA; microarray. China
28498357 biomarker na compound Adiponectin  na na na na adipoR1, AMPK, p38, ERK suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28498357 Int J Mol Sci 2017 Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts Limin Luo; Jun Li; Han Liu; Xiaoqing Jian; Qianlei Zou; Qing Zhao; Qu Le; Hongdou Chen 0; Xinghua Gao; Chundi He adiponectin; adiponectin receptors; connective tissue growth factor; fibroblasts; keloid. China
28108300 biomarker na protein TIEG1 7071 KLF10 na na TGF-β1/Smad suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28108300 J Invest Dermatol 2017 TIEG1 Represses Smad7-Mediated Activation of TGF-β1/Smad Signaling in Keloid Pathogenesis Zhi-Cheng Hu; Fen Shi; Peng Liu; Jian Zhang; Dong Guo; Xiao-Ling Cao; Chu-Fen Chen; Shan-Qiang Qu; Jia-Yuan Zhu; Bing Tang Fibroblast, GC-box/Sp1 sites, Keloid, Smad7, TGFr β, TGFr-β inducible early gene-1 China
27717618 biomarker na miRNA miR-21 406991 MIR21 na na Smad7 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27717618 Burns 2017 miR-21 promotes collagen production in keloid via Smad7 Renpeng Zhou; Chen Wang; Congji Wen; Danru Wang Extracellular matrix; Keloid; Smad7; miR-21. China
28437551 biomarker na protein IL-6 3569 IL6 na na na na variation PCR-RFLP, ELISA https://pubmed.ncbi.nlm.nih.gov/28437551 Genet Mol Res 2017 Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population X J Zhu; W Z Li; H Li; C Q Fu; J Liu Keloid scar, IL-6, Polymorphism China
28485781 biomarker na gene hTERT-ASODN 7015 TERT na na telomerase suppressor increased qRT-PCR, MTT https://pubmed.ncbi.nlm.nih.gov/28485781 Eur Rev Med Pharmacol Sci 2017 Effects of hTERT antisense oligodeoxynucleotide on cell apoptosis and expression of hTERT and bcl-2 mRNA in keloid fibroblasts Y Huang; L-X Lin, Q-X Bi, P Wang, X-M Wang, J Liu, Y-T Wang na China
28192879 biomarker na protein IRF3 3661 IRF3 na na TGF-β1/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28192879 Biomed Pharmacother 2017 Knockdown of IRF3 inhibits extracellular matrix expression in keloid fibroblasts Yi Zhang; Li Zhang; Xiao-Hua Lin; Zhi-Ming Li; Qi-Yu Zhang Extracellular matrix ; IRF3; Keloid fibroblasts; TGF-β1/Smad pathway. China
27840235 biomarker na protein S100A12 6283 S100A12 na na na driver increased IF, WB https://pubmed.ncbi.nlm.nih.gov/27840235 J Invest Dermatol 2017 S100A12 Induced in the Epidermis by Reduced Hydration Activates Dermal Fibroblasts and Causes Dermal Fibrosis Jingling Zhao; Aimei Zhong; Emily E Friedrich; Shengxian Jia; Ping Xie; Robert D Galiano; Thomas A Mustoe; Seok Jong Hong S100A12, Hypertrophic scar, Fibrosis, Rabbit hypertrophic scar model, Stratified keratinocyte culture USA
27651436 biomarker na miRNA microRNA-205 406988 MIR205 na na PI3K/Akt suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27651436 Exp Biol Med (Maywood) 2017 Upregulation of microRNA-205 suppresses vascular endothelial growth factor expression-mediated PI3K/Akt signaling transduction in human keloid fibroblasts Gang An; Shuzeng Liang; Chunhong Sheng; Yan Liu; Wei Yao  Akt; Keloid; microRNA-205; vascular endothelial growth factor. China
27175945 biomarker na protein TGFβ 7040 TGFB1, SMAD2 na na na na na bioinformatic approach https://pubmed.ncbi.nlm.nih.gov/27175945 Acta Derm Venereol 2017 Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts Adam Taylor; David C Budd, Barbara Shih, Oliver Seifert, Andrew Beaton, Tracey Wright, Maria Dempsey, Fiona Kelly, Julia Egerton, Richard P Marshall, Nicola Aston, Ardeshir Bayat keloid disease; gene expression; microarray; TGFβ1; upstream regulator UK
30070797 biomarker na protein ITGB5 3693 ITGB5 na na na driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30070797 Zhonghua Zheng Xing Wai Ke Za Zhi 2017 [The effects of down-regulated ITGB5 expression on the proliferation of keloid fibroblasts] Tongtong Yang, Minliang Chen, Kui Ma, Xiaobing Fu na China
28088270 biomarker na protein PAI-1 5054 SERPINE1 na na na na increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/28088270 Kaohsiung J Med Sci 2017 Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population Zhen-Hua Gong; Jian-Feng Ji; Jun Yang; Tie Xiang; Chang-Kai Zhou; Xuan-Liang Pan; Jian Yao Chinese population; Keloid disease; Peripheral blood lymphocytes; Plasminogen activator inhibitor; Vitamin D receptor. China
27670081 biomarker na protein heat shock protein 90 3320 HSP90AA1 na na TGF-β  driver increased WB, IHC https://pubmed.ncbi.nlm.nih.gov/27670081 Tissue Cell 2016 Modulation of heat shock protein 90 affects TGF-β-induced collagen synthesis in human dermal fibroblast cells Sae Bin Lee; A-Ram Lim; Dong Kyun Rah; Kyung Soo Kim; Hyun Jin Min 17AAG; Collagen; Hsp 90; Smad 2/3; TGF-β. South Korea
27897224 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na PTB driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27897224 Sci Rep 2016 TGF-β1 Induces Polypyrimidine Tract-Binding Protein to Alter Fibroblasts Proliferation and Fibronectin Deposition in Keloid Hu Jiao; Ping Dong; Li Yan; Zhigang Yang; Xiaoyan Lv; Qiuchen Li; Xianlei Zong; Jincai Fan; Xin Fu; Xia Liu; Ran Xiao  na China
27424317 biomarker na protein CD138 6382 SDC1 na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/27424317 J Invest Dermatol 2016 Identification of a Potential Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is Overexpressed in Keloid Scar Tissue Rania A Bagabir; Farhatullah Syed; Patrick Shenjere; Ralf Paus; Ardeshir Bayat na UK
27698867 biomarker na lncRNA H19 283120 H19 na na mTOR, VEGF driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27698867 Oncol Lett 2016 Long non-coding RNA H19 promotes the proliferation of fibroblasts in keloid scarring Jie Zhang; Cai Yue Liu; Yun Wan; Li Peng; Wen Fang Li; Jia Xuan Qiu  keloid; long non-coding RNA H19; mammalian target of rapamycin; proliferation; vascular endothelial growth factor. China
27525969 biomarker na protein NLRC5 84166 NLRC5 na na TGF-β1/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27525969 Biomed Pharmacother 2016 Silencing NLRC5 inhibits extracellular matrix expression in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway Hai-Li Ma; Xue-Fu Zhao; Guan-Zhi Chen; Rong-Hui Fang; Fu-Ren Zhang Keloid fibroblasts ; NLRC5; TGF-β1/Smad signaling; TGF-β1. China
29786372 biomarker na peroxisome peroxisome 5830 PEX5 na na PPAR-γ na na IHC https://pubmed.ncbi.nlm.nih.gov/29786372 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2016 [EXPRESSION AND SIGNIFICANCE OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR γ IN KELOID] Lei Lei; Yiling Deng; Junjie Chen; Ying Cen  Immunohistochemistry; Keloid; Peroxisome proliferator activated receptor γ. China
27596120 biomarker na miRNA MiR-21-5p 406991 MIR21 na na EMT driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27596120 Sci Rep 2016 MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes Li Yan; Rui Cao; YuanBo Liu; LianZhao Wang; Bo Pan; XiaoYan Lv; Hu Jiao; Qiang Zhuang; XueJian Sun; Ran Xiao  na China
27554193 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na MicroRNA-21 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27554193 Sci Rep 2016 TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21 Ying Liu; Yue Li; Ning Li; Wen Teng; Min Wang; Yingbo Zhang; Zhibo Xiao  na China
27574697 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na EMT driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27574697 Burns Trauma 2016 Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1 Jennifer M Hahn; Kevin L McFarland; Kelly A Combs; Dorothy M Supp Epithelial-mesenchymal transition; Fibrosis; Keloid; Keratinocyte; Scar; Wound healing USA
27648136 biomarker na peroxisome peroxisome na na na na TGF-β1, Axl na increased  qRT-PCR, ELISA, WB, protein array, luciferase, ChIP https://pubmed.ncbi.nlm.nih.gov/27648136 Am J Transl Res 2016 Peroxisome proliferator-activated receptor-γ agonist troglitazone suppresses transforming growth factor-β1 signalling through miR-92b upregulation-inhibited Axl expression in human keloid fibroblasts in vitro Hua-Yu Zhu; Wen-Dong Bai, Jun Li; Ke Tao; Hong-Tao Wang; Xue-Kang Yang; Jia-Qi Liu; Yun-Chuan Wang; Ting He; Song-Tao Xie; Da-Hai Hu   Axl; Benign tumor; PPAR-γ; TGF-β signaling; keloid; miR-92b. China
27426733 biomarker na gene MAP3K7 6885 MAP3K7 na na TAK1 na variation qRT-PCR, Whole-Exome Sequencing https://pubmed.ncbi.nlm.nih.gov/27426733 Am J Hum Genet 2016 Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia Emma M Wade; Philip B Daniel; Zandra A Jenkins; Aideen McInerney-Leo, Paul Leo, Tim Morgan; Marie Claude Addor, Lesley C Adès, Debora Bertola, Axel Bohring, Erin Carter, Tae-Joon Cho, Hans-Christoph Duba, Elaine Fletcher 0, Chong A Kim, Deborah Krakow; Eva Morava, Teresa Neuhann, Andrea Superti-Furga, Irma Veenstra-Knol, Dagmar Wieczorek, Louise C Wilson, Raoul C M Hennekam, Andrew J Sutherland-Smith, Tim M Strom0, Andrew O M Wilkie, Matthew A Brown, Emma L Duncan, David M Markie2, Stephen P Robertson3 na New Zealand
27211019 biomarker na cell bone marrow derived MSCs na na na na proliferative and profibrotic phenotype suppressor na qRT-PCR, WB, IF https://pubmed.ncbi.nlm.nih.gov/27211019 J Dermatol Sci 2016 Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling Fengjun Fang; Ru-Lin Huang; Yongchao Zheng; Ming Liu; Ran Huo BMSC; Hypertrophic scar; Keloid; Profibrotic; Proliferative. China
29786325 biomarker na protein smad7  4092 SMAD7 na na na suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/29786325 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2016 [Effects of over-expressing smad7 gene on keloid fibroblasts] Zhenwei Chen; Yin Liu; Minqin Xiao; Hong Xiao; Wei Qiu; Yanan Zhao  Apoptosis; Keloids fibroblasts; Signaling pathway; Smad7. China
27030305 biomarker na protein OCT4, SOX2, pSTAT3, NANOG na na na na na na na IHC https://pubmed.ncbi.nlm.nih.gov/27030305 J Clin Pathol 2016 Expression of embryonic stem cell markers in keloid-associated lymphoid tissue Chelsea Grant; Daria A Chudakova; Tinte Itinteang; Alice M Chibnall; Helen D Brasch; Paul F Davis; Swee T Tan DERMATOPATHOLOGY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; SKIN. New Zealand
27025872 biomarker na protein AKR1B10 57016 AKR1B10 na na retinoic acid na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27025872 J Invest Dermatol 2016 The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease Natalie Jumper; Tom Hodgkinson; Guyan Arscott; Yaron Har-Shai; Ralf Paus; Ardeshir Bayat na UK
26566758 biomarker na miRNA miR-29a 407021 MIR29A na na na suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26566758 Clin Exp Dermatol 2016 A novel regulatory function for miR-29a in keloid fibrogenesis G-Y Zhang; L-C Wu; T Liao; G-C Chen; Y-H Chen; Y-X Zhao; S-Y Chen; A-Y Wang; K Lin; D-M Lin; J-Q Yang; W-Y Gao; Q-F Li  na China
26553652 biomarker na protein TGF-β1, bFGF 7040, 2247 TGFB1, FGF2 na na na na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26553652 Med Mol Morphol 2016 Upregulation of TGF-β1 and basic FGF in elastofibroma: an immunohistochemical analysis Akiko Imanishi; Hisayoshi Imanishi; Yasuhiko Yoshida; Aya Okabayashi; Chiharu Tateishi; Hirofumi Ikushima; Ren Nagasako; Koichi Nakagawa; Daisuke Tsuruta  Basic FGF; Dermatofibroma; Elastofibroma; Fibroblast; TGF-β1. Japan
27090737 biomarker na lncRNA lncRNA-ATB 114004396 LNCRNA-ATB na na ZNF217  suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27090737 Sci Rep 2016 Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts Hua-Yu Zhu; Wen-Dong Bai; Chao Li; Zhao Zheng; Hao Guan; Jia-Qi Liu; Xue-Kang Yang; Shi-Chao Han; Jian-Xin Gao; Hong-Tao Wang; Da-Hai Hu  na China
26986142 biomarker na protein CKLF-1 51192 CKLF na na inflammation na increased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/26986142 Medicine (Baltimore) 2016 Chemokine-Like Factor 1 (CKLF-1) is Overexpressed in Keloid Patients: A Potential Indicating Factor for Keloid-Predisposed Individuals Mingzi Zhang; Ying Xu, Yifang Liu, Yingying Cheng, Pengxiang Zhao, Hao Liu, Youbin Wang, Xuemei Ma na China
26234705 biomarker na protein HGF 3082 HGF na na MMP-1 na na qRT-PCR, ELISA https://pubmed.ncbi.nlm.nih.gov/26234705 Int J Dermatol 2016 Hepatocyte growth factor-expressing adenovirus upregulates matrix metalloproteinase-1 expression in keloid fibroblasts Yeo Reum Jeon; Hyo Min Ahn; Il Kyu Choi; Chae Ok Yun; Dong Kyun Rah; Dae Hyun Lew; Won Jai Lee  na South Korea
26308156 biomarker na protein AKR1C3 8644 AKR1C3 na na PGD2 suppressor increased IHC, WB https://pubmed.ncbi.nlm.nih.gov/26308156 Exp Dermatol 2016 The role of aldo-keto reductase 1C3 (AKR1C3)-mediated prostaglandin D2 (PGD2) metabolism in keloids Alon Mantel; Austin Newsome; Theresa Thekkudan; Robert Frazier; Meena Katdare P38-MAPK; aldo-keto reductase 1C3; fibrosis; keloid; prostaglandin. USA
26446645 biomarker na protein Hsp70 820438 HSP70 na na Collagen driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26446645 Yonsei Med J 2015 Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts Jung U Shin; Won Jai Lee; Thanh-Nga Tran; Inhee Jung; Ju Hee Lee HSPs; Hsp70; keloids. South Korea
26397149 biomarker na lncRNA CACNA1G-AS1 253962 CACNA1G-AS1 na na na na increased qRT-PCR, microarray https://pubmed.ncbi.nlm.nih.gov/26397149 Int J Oncol 2015 LncRNA expression profiles and validation in keloid and normal skin tissue Xuebing Liang; Lin Ma; Xiao Long; Xiaojun Wang  keloid, lncRNA, gene expression, calcium channel, CACNA1G-AS1 China
26535660 biomarker na protein PTEN 5728 PTEN na na PTEN/PI3K/AKT na decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26535660 Genet Mol Res 2015 NEDD4-1 and PTEN expression in keloid scarring P F Sang; H Wang; M Wang; C Hu; J S Zhang; X J Li; F Zhu  na China
27511505 biomarker na gene COL1A1 1277 COL1A1 na na na na variation statistical analysis https://pubmed.ncbi.nlm.nih.gov/27511505 Turk J Med Sci 2016 Genetic association of the COL1A1 gene promoter -1997 G/T (rs1107946) andSp1 +1245 G/T (rs1800012) polymorphisms and keloid scars in a Jeddah population Sahah A Linjawi; Sanaa E Tork; Raysa M Shaibah  COL1A1; Keloid; collagen; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism. Egypt
27158346 biomarker na protein NEDD4  4734 NEDD4 na na na na variation GWAS https://pubmed.ncbi.nlm.nih.gov/27158346 Am J Transl Res 2016 NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population Ying Zhao; Sheng-Li Liu; Jian Xie; Mao-Qian Ding; Meng-Zhu Lu; Lan-Fang Zhang; Xiu-Hua Yao; Bai Hu; Wen-Sheng Lu; Xiao-Dong Zheng Keloids; NEDD4; SNP rs2271289; association study. China
26824743 biomarker na protein TSLP 85480 TSLP na na CXCR4/SDF-1 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26824743 J Invest Dermatol 2016 TSLP Is a Potential Initiator of Collagen Synthesis and an Activator of CXCR4/SDF-1 Axis in Keloid Pathogenesis Jung U Shin; Seo Hyeong Kim; Hyeran Kim; Ji Yeon Noh; Shan Jin; Chang Ook Park; Won Jai Lee; Dong Won Lee; Ju Hee Lee; Kwang Hoon Lee NEDD4-1; PTEN; Pathological scar; Keloid South Korea
26644005 biomarker na protein LTBP-2 4053 LTBP2 na na FGF-2 na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26644005 J Mol Histol 2016 Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar Mohamed A Sideek; Abdulrahman Teia; Zlatko Kopecki; Allison J Cowin; Mark A Gibson FGF-2; Fibrosis; Hypertrophic scar; Keloid; LTBP-2. Australia
26095157 biomarker na protein Fibulin-5 105095915 FBLN5 na na integrin beta-1 suppressor na IHC https://pubmed.ncbi.nlm.nih.gov/26095157 Int J Cosmet Sci 2016 Fibulin-5 regulates keloid-derived fibroblast-like cells through integrin beta-1 N Furie; D Shteynberg; R Elkhatib; L Perry; Y Ullmann; Y Feferman; M Preis; M Y Flugelman; I Tzchori cell culture; fibulin-5; integrin β-1; keloid; microbiology; skin physiology/structure. Israel
28101509 biomarker na lncRNA lncRNA expression profile na na na na na na na Microarray https://pubmed.ncbi.nlm.nih.gov/28101509 Biomed Res Int 2016 Expression Profile of Long Noncoding RNAs in Human Earlobe Keloids: A Microarray Analysis Liang Guo; Kai Xu; Hongbo Yan; Haifeng Feng; Linlin Chai; Guozheng Xu na China
27915346 biomarker na miRNA MiR-181a 735252 Mir181a-1 na na AKT  driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27915346 Cell Physiol Biochem 2016 MiR-181a Targets PHLPP2 to Augment AKT Signaling and Regulate Proliferation and Apoptosis in Human Keloid Fibroblasts Zhen Rang; Zong-Yang Wang, Qiu-Yu Pang, You-Wei Wang, Ge Yang, Fan Cui miR-181a; PHLPP2; AKT; Keloid fibroblasts; Proliferation; Apoptosis China
27855376 biomarker na protein GDF-9 2661 GDF9 na na Smad2/3 driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27855376 Cell Physiol Biochem 2016 Growth Differentiation Factor-9 Promotes Fibroblast Proliferation and Migration in Keloids through the Smad2/3 Pathway Zhaohua Jiang; Qingxiong Yu, Lingling Xia, Yi Zhang, Xiuxia Wang, Xiaoli Wu, Zhen Gao Keloids; Fibroblast; Growth differentiation factor-9; Smad pathway China
27771714 biomarker na protein Wnt/β-Catenin na na na na Telomerase driver increased qRT-PCR, WB, MTT https://pubmed.ncbi.nlm.nih.gov/27771714 Cell Physiol Biochem 2016 Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase Dongmei Yu; Yong Shang, Jian Yuan, Shuang Ding, Sai Luo, Lijun Hao Wnt; β-catenin; Telomerase; Keloid; Cell proliferation; Apoptosis China
27132794 biomarker na miRNA Serum miRNAs profile na na na na na na na miRNA microarray analysis https://pubmed.ncbi.nlm.nih.gov/27132794 Curr Mol Med 2016 Serum miRNAs Signature Plays an Important Role in Keloid Disease Y Luan, Y Liu, C Liu, Q Lin, F He, X Dong; Z Xiao Keloid, microRNA, serum, pathogenesis, scar, etiology. USA
26512164 biomarker na protein Nrf2 4780 NFE2L2 na na bcl-2 na decreased WB https://pubmed.ncbi.nlm.nih.gov/26512164 Ann Dermatol 2015 Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue Yoon Jin Lee; Sun Bum Kwon; Chul Han Kim; Hyun Deuk Cho; Hae Seon Nam; Sang Han Lee; Mi Woo Lee; Doo Hyun Nam; Chang Yong Choi; Moon Kyun Cho Apoptosis; BCL2; Keloid; NF-E2-related factor 2; Reactive oxygen species. South Korea
26045366 biomarker na protein DARC 57977070 darC na na CCL2 na increased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/26045366 Gene 2015 The role of Duffy antigen receptor for chemokines in keloids Ying Chen; Nong Liao; Feng Lu; Hui Peng; Jianhua Gao Chemokine; Duffy antigen receptor for chemokines; Keloids; Migration; Proliferation. China
26629012 biomarker na protein RACK1 10399 RACK1 Ingenol mebutate DB05013 TGF-β1/Smad suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26629012 Int J Clin Exp Med 2015 Overexpression of RACK1 inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway Ping Zhou; Lina Shi; Qing Li; Di Lu  RACK1; TGF-β1/Smad signaling pathway; collagen synthesis; keloid fibroblasts . China
26313837 biomarker na protein Hsp90 2543539 hsp90 na na TGF-β1/Smad2/3 driver increased ELISA, WB https://pubmed.ncbi.nlm.nih.gov/26313837 Plast Reconstr Surg 2015 Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model Won Jai Lee; Ju Hee Lee, Hyo Min Ahn, Seung Yong Song, Yong Oock Kim, Dae Hyun Lew, Chae-Ok Yun na South Korea
26357464 biomarker na protein chymase 1215 CMA1 na na TGF-β1 na increased WB https://pubmed.ncbi.nlm.nih.gov/26357464 Drug Des Devel Ther 2015 Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids Ru Wang; Junjie Chen; Zhenyu Zhang; Ying Cen  angiotensin II; chymase; pathological scar; therapy. China
26550247 biomarker na protein BAMBI 25805 BAMBI na na TGF-β1 suppressor decreased WB, MTT https://pubmed.ncbi.nlm.nih.gov/26550247 Int J Clin Exp Med 2015 BAMBI inhibits skin fibrosis in keloid through suppressing TGF-β1-induced hypernomic fibroblast cell proliferation and excessive accumulation of collagen I Lixin Lin; Yuting Wang; Wenyi Liu; Yong Huang  BMP and activin membrane-bound inhibitor; Keloid; collagens; fibroblast cell proliferation; TGFr-β 1. China
26263555 biomarker na protein LTBP-2 4053 LTBP2 na na FGF-2 suppressor na Confocal microscopy https://pubmed.ncbi.nlm.nih.gov/26263555 PLoS One 2015 LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation Clementine Menz; Mahroo K Parsi; Julian R J Adams; Mohamed A Sideek; Zlatko Kopecki; Allison J Cowin; Mark A Gibson  na Australia
26248335 biomarker na cell Normal Human Lung Epithelial Cells na na na na TGF-β suppressor na WB https://pubmed.ncbi.nlm.nih.gov/26248335 PLoS One 2015 Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2 Amali P Epa; Thomas H Thatcher; Stephen J Pollock; Lindsay A Wahl; Elizabeth Lyda; R M Kottmann; Richard P Phipps; Patricia J Sime na USA
25845828 biomarker na protein Wnt 3a 89780 WNT3A na na na na increased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/25845828 Wound Repair Regen 2015 Endothelial-to-mesenchymal transition induced by Wnt 3a in keloid pathogenesis Won Jai Lee; Ji Hun Park; Jung U Shin; Hyun Noh; Dae Hyun Lew; Woo Ick Yang; Chae Ok Yun; Kwang Hoon Lee; Ju Hee Lee na South Korea
26157288 biomarker na protein TGF-β1, TGF-β2 7040, 7042 TGFB1, TGFB2 na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/26157288 Indian J Med Paediatr Oncol 2015 Transforming growth factor-β1 and TGF-β2 act synergistically in the fibrotic pathway in oral submucous fibrosis: An immunohistochemical observation Venkatesh Viswanath Kamath; Shruti Krishnamurthy; Krishnanand P Satelur; Komali Rajkumar  Immunohistochemistry; oral submucous fibrosis; scar; TGFr-β1; TGFr-β2. India
25466519 biomarker na culture media B16 M-CM na na na na na suppressor na WB https://pubmed.ncbi.nlm.nih.gov/25466519 J Surg Res 2015 Antifibrogenic effects of B16 melanoma-conditioned medium Chung Hun Kim; Wang Kyun Kim; Chengjin Li; Jea Yong Song; Jong Hyuk Sung; Seung Yong Song Hypertrophic scar; Keloid; Melanoma; Scar. South Korea
25385294 biomarker na protein Tcf/Lef 373203 Tcf/Lef na na β-catenin driver na Genome-wide profiling https://pubmed.ncbi.nlm.nih.gov/25385294 J Pathol 2015 Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes Emily Hamburg-Shields; Gregg J DiNuoscio, Nathaniel K Mullin, Robert Lafyatis, Radhika P Atit dermis; extracellular matrix; fibroblast; fibrosis; β-catenin. USA
26211188 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na EMT na na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/26211188 Zhonghua Zheng Xing Wai Ke Za Zhi 2015 [In vitro study of TGF-β1-induced epithelial-mesenchymal transition of keloid epithelial cells] Li Yan, Rui Cao, Bo Pan, Lianzhao Wang, Xiaoyan Lyu, Xuejian Sun, Ran Xiao na China
25858630 biomarker na cell Mesenchymal stem cells na na na na TGF-β3 suppressor na IHC, WB https://pubmed.ncbi.nlm.nih.gov/25858630 Int J Low Extrem Wounds 2015 Mesenchymal stem cells suppress fibroblast proliferation and reduce skin fibrosis through a TGF-β3-dependent activation Yan Wu; Yan Peng; Dongyun Gao; Changjiang Feng; Xiaohuan Yuan; Houzhong Li; Ying Wang; Lan Yang; Sha Huang; Xiaobing Fu mesenchymal stem cells; paracrine; skin fibrosis; TGFr-β. China
25932232 biomarker na gene FOXL2 668 FOXL2 na na na na variation GWAS https://pubmed.ncbi.nlm.nih.gov/25932232 Int J Clin Exp Med 2015 SNP rs1511412 in FOXL2 gene as a risk factor for keloid by meta analysis Wensheng Lu; Xiaodong Zheng; Shengli Liu; Maoqian Ding; Jian Xie; Xiuhua Yao; Lanfang Zhang; Bai Hu  Meta analysis; SNP; keloid. China
25369801 biomarker na protein periostin 10631 POSTN na na ERK 1/2, focal adhesion kinase driver increased IHC, WB https://pubmed.ncbi.nlm.nih.gov/25369801 Mol Med Rep 2015 Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin‑1 Zhe Zhang; Fangfei Nie; Xinlei Chen; Zelian Qin; Chunfu Kang; Bin Chen; Jianxun Ma; Bolin Pan; Yongguang Ma  periostin, fibroblast, keloid, endothelial cells, angiogene China
25502330 biomarker na protein psoriasin, koebnerisin 6278, 112488748 S100A7, S100A15A na na ECM suppressor decreased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/25502330 Skin Pharmacol Physiol 2015 The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts Gerd G Gauglitz; Daniela Bureik, Stephanie Zwicker, Thomas Ruzicka, Ronald Wolf na Germany
25078664 biomarker na protein Gαi1/3-Gab1 2549 GAB1 na na PI3K-AKT-mTORC1 na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/25078664 J Invest Dermatol 2015 Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation Yi-Ming Zhang; Zhi-Qing Zhang; Yuan-Yuan Liu; Xin Zhou; Xiao-Hua Shi; Qin Jiang; Dong-Li Fan; Cong Cao na China
24957188 biomarker photodynamic therapy protein RUNX3 864 RUNX3 pheophorbide a na na driver increased IHC https://pubmed.ncbi.nlm.nih.gov/24957188 Lasers Med Sci 2015 RUNX3 expression is associated with sensitivity to pheophorbide a-based photodynamic therapy in keloids Zhenlong Zheng; Lianhua Zhu, Xianglan Zhang, Lianhua Li, Sook Moon, Mi Ryung Roh, Zhehu Jin RUNX3; Pheophorbide a-based photodynamic therapy; Keloid China
25154292 biomarker na protein IGF-IR 3480 IGF1R na na na na increased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/25154292 Clin Exp Dermatol 2014 Expression of insulin-like growth factor-1 receptor in keloid and hypertrophic scar Z-C Hu; B Tang, D Guo, J Zhang, Y-Y Liang, D Ma, J-Y Zhu na China
25228082 biomarker na miRNA MiR-200b 406984 MIR200B na na apoptosis suppressor decreased miRNA microarray https://pubmed.ncbi.nlm.nih.gov/25228082 J Dermatol 2014 Overexpression of miR-200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro Ping Li; Quan-Yong He, Cheng-Qun Luo TGF-β1; collagen; hypertrophic scarring; in vitro; miRNA-200b; α-SMA. China
25357030 biomarker na cell Adipose tissue-derived stromal cells na na na na TGF-β1 suppressor na qRT-PCR, WB, IF https://pubmed.ncbi.nlm.nih.gov/25357030 Plast Reconstr Surg 2014 Adipose tissue-derived stromal cells inhibit TGF-β1-induced differentiation of human dermal fibroblasts and keloid scar-derived fibroblasts in a paracrine fashion Maroesjka Spiekman; Ewa Przybyt, Josée A Plantinga, Susan Gibbs, Berend van der Lei, Martin C Harmsen na Netherlands
25357050 biomarker na miRNA MicroRNA-21 406991 MIR21 na na PTEN na na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/25357050 Plast Reconstr Surg 2014 MicroRNA-21 affects proliferation and apoptosis by regulating expression of PTEN in human keloid fibroblasts Ying Liu; Xiaoxue Wang, Daping Yang, Zhibo Xiao, Xi Chen na China
25522488 biomarker na protein hIL-24 11009 IL24 na na na suppressor na MTT, flow cytometer https://pubmed.ncbi.nlm.nih.gov/25522488 Zhonghua Zheng Xing Wai Ke Za Zhi 2014 [Effect of lentivirus-mediated hIL-24 gene on proliferation, migration and invasion of keloid fibroblasts] Wu Zhiyuan, Shi Yucang, Liang Jie, Xu Xiaxing, Wu Zhixian, Li Ran na China
25010393 biomarker na protein FOXO1 2308 FOXO1 na na na driver increased WB https://pubmed.ncbi.nlm.nih.gov/25010393 Am J Pathol 2014 Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring Ryoichi Mori; Katsuya Tanaka; Maiko de Kerckhove; Momoko Okamoto; Kazuya Kashiyama; Katsumi Tanaka; Sangeun Kim; Takuya Kawata; Toshimitsu Komatsu; Seongjoon Park; Kazuya Ikematsu; Akiyoshi Hirano; Paul Martin; Isao Shimokawa na Japan
24981855 biomarker na protein NADPH oxidase-2 50506 DUOX2 na na TGF-β1/Smad2 na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/24981855 Exp Dermatol 2014 NADPH oxidase-2 is a key regulator of human dermal fibroblasts: a potential therapeutic strategy for the treatment of skin fibrosis Guo-You Zhang; Liang-Cai Wu, Tao Dai, Shi-Yi Chen, An-Yuan Wang, Kang Lin, Da-Mu Lin, Jing-Quan Yang, Biao Cheng, Li Zhang, Wei-Yang Gao, Zhi-Jie Li NADPH; TGF-β1; fibroblasts; fibrosis; wound healing. China
24788198 biomarker na protein periostin 10631 POSTN hypoxia na αvβ3 integrin-PI3K/Akt driver increased qRT-PCR, WB, ELISA https://pubmed.ncbi.nlm.nih.gov/24788198 Int J Mol Med 2014 Increased periostin expression affects the proliferation, collagen synthesis, migration and invasion of keloid fibroblasts under hypoxic conditions Zhe Zhang; Fangfei Nie; Chunfu Kang; Bin Chen; Zelian Qin; Jianxun Ma; Yongguang Ma; Xia Zhao  periostin, hypoxia, fibroblast, keloid, hypoxia-inducible factor China
25120737 biomarker na protein mast cell chymase na na na na TGF-β/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/25120737 Int J Clin Exp Pathol 2014 Mast cell chymase in keloid induces profibrotic response via transforming growth factor-β1/Smad activation in keloid fibroblasts Xianglin Dong; Chuanshan Zhang; Shaolin Ma; Hao Wen Mast cell chymase; Smad; fibroblast; keloid; TGFr-β1. China
24715059 biomarker na protein CCN3 4856 CCN3 na na ECM suppressor increased qRT-PCR, WB, MTT https://pubmed.ncbi.nlm.nih.gov/24715059 Int J Mol Med 2014 Effects of CCN3 on fibroblast proliferation, apoptosis and extracellular matrix production Zhanping Ren; Yuxia Hou; Siwei Ma; Yongwei Tao; Jinfeng Li; Huiqin Cao; Lingling Ji CCN3, fibroblast, proliferation, apoptosis, extracellular matrix, α-smooth muscle actin, TGFr-β1/Smad China
25860431 biomarker na protein DNMT1 1786 DNMT1 na na TGF-β/Smad driver increased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/25860431 Wounds 2014 The Expression of DNMT1 in Pathologic Scar Fibroblasts and the Effect of 5-aza-2-Deoxycytidine on Cytokines of Pathologic Scar Fibroblasts Yang E, Zou Qipa, Zhang Hengshu na China
25112012 biomarker na pathway notch na na na na na na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/25112012 Zhonghua Zheng Xing Wai Ke Za Zhi 2014 [The expressions of notch genes in human keloid-derived mesenchymal-like stem cells] Chengliang Deng, Bo Wang, Ziyang Zhang, Guangfeng Sun, Jingjing Zhu, Dali Wang, Limei Yu na China
24402284 biomarker na protein Annexin A2 302 ANXA2 na na na suppressor increased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/24402284 Arch Dermatol Res 2014 Annexin A2 participates in human skin keloid formation by inhibiting fibroblast proliferation Soon Heum Kim; Seung-Hyo Jung, Hong Chung, Dong In Jo, Cheol Keun Kim, Seung Hwa Park, Kyung-Jong Won, Hyun Soo Jeon, Bokyung Kim Annexin A2 Dermal fibroblast Keloid Proliferation Proteomics South Korea
24782087 biomarker na miRNA miR-199a-5p 406976 MIR199A1 na na na na decreased miRNA microarray https://pubmed.ncbi.nlm.nih.gov/24782087 Genet Mol Res 2014 Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts Z-Y Wu; L Lu; J Liang; X-R Guo; P H Zhang; S-J Luo Keloid; Expression profile; miR-199a-5p; Keloid fibroblast; KF Proliferation China
24617809 biomarker na cell Regulatory T cells na na na na inflammation suppressor na IHC https://pubmed.ncbi.nlm.nih.gov/24617809 Exp Dermatol 2014 Treg-enriched CD4+ T cells attenuate collagen synthesis in keloid fibroblasts Naoki Murao; Ken-Ichiro Seino, Toshihiko Hayashi, Masaki Ikeda, Emi Funayama, Hiroshi Furukawa, Yuhei Yamamoto, Akihiko Oyama coculture; fibroblast; keloid; regulatory T cell. Japan
24061401 biomarker na protein COX-1,COX-2 6775083, 6775079 COX1, COX2 na na inflammation na increased IHC https://pubmed.ncbi.nlm.nih.gov/24061401 Am J Dermatopathol 2014 Immunohistochemical evaluation of COX-1 and COX-2 expression in keloid and hypertrophic scar Asmaa G Abdou; Alaa H Maraee, Hala F Abd-Elsattar Saif COX-1, COX-2, keloid, hypertrophic scar Egypt
24941761 biomarker na pathway CASK/Id1 na na na na na na increased qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/24941761 Zhonghua Zheng Xing Wai Ke Za Zhi 2014 [Preliminary study on CASK/Id1 pathway in fibroblasts of human keloid] Liang Xiao, Zhibo Sun, Yong Ke, Zhihong Yu, Guangzhao He, Yuhan Ren na China
24436441 biomarker na pathway human Wharton's jelly mesenchymal stem cell paracrine signaling na na na na na no effect na qRT-PCR, IF https://pubmed.ncbi.nlm.nih.gov/24436441 Stem Cells Transl Med 2014 Effect of human Wharton's jelly mesenchymal stem cell paracrine signaling on keloid fibroblasts Anna I Arno; Saeid Amini-Nik, Patrick H Blit, Mohammed Al-Shehab, Cassandra Belo, Elaine Herer, Marc G Jeschke Fibrosis; Keloid; Scar; Skin; Stem cells; Wharton’s jelly. Canada
24042342 biomarker na protein MMP-1 4312 MMP1 na na na driver na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/24042342 J Invest Dermatol 2014 siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I Masayo Aoki; Koichi Miyake; Rei Ogawa; Teruyuki Dohi; Satoshi Akaishi; Hiko Hyakusoku; Takashi Shimada na Japan
25201121 biomarker na gene ADAM33  80332 ADAM33 na na na na variation PCR-RFLP https://pubmed.ncbi.nlm.nih.gov/25201121 Cell Physiol Biochem 2014 Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population Jianyu Han; Jianfeng Han, Dongmei Yu, Jinling Xiao, Yong Shang, Lijun Hao Keloid scar; ADAM33; Single nucleotide polymorphism; Association study China
24300717 biomarker na protein c-Met phosphorylation 4233 MET na na na na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/24300717 Pathology 2014 Increased c-Met phosphorylation is related to keloid pathogenesis: implications for the biological behaviour of keloid fibroblasts Zhehu Jin  Keloid pathogenesis, phospho-Met expression China
24228510 biomarker na miRNA miR-199a-5p 406976 MIR199A1 na na na na decreased miRNA microarray https://pubmed.ncbi.nlm.nih.gov/24228510 Zhonghua Zheng Xing Wai Ke Za Zhi 2013 [Identification of differently expressed microRNAs in keloid and pilot study on biological function of miR-199a-5p] Zhi-Yuan Wu; Ling Lu, Xiao-Rui Guo, Pei-Hua Zhang na China
23667473 biomarker na gene NEDD4 4734 NEDD4 na na na na variation GWAS https://pubmed.ncbi.nlm.nih.gov/23667473 PLoS One 2013 Association study confirmed susceptibility loci with keloid in the Chinese Han population Fei Zhu; Baoyu Wu, Ping Li, Jianbo Wang, Huayang Tang, Ye Liu, Xianbo Zuo, Hui Cheng, Yantao Ding, Wen Wang, Yujuan Zhai, Fangfang Qian, Wenju Wang, Xiangfeng Yuan, Jing Wang, Weiwei Ha, Junsheng Hou, Fusheng Zhou, Yin Wang, Jinping Gao, Yujun Sheng, Liangdan Sun, Jianjun Liu, Sen Yang, Xuejun Zhang na China
23614752 biomarker na protein Hyaluronan Synthase 3036 HAS1 na na na na increased IHC  https://pubmed.ncbi.nlm.nih.gov/23614752 Exp Dermatol 2013 Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin Gary P Sidgwick, Syed A Iqbal, Ardeshir Bayat extracellular matrix – hyaluronan synthase – hyaluronidase –keloid disease – wound healing UK
22981800 biomarker na protein TLR4/7 7099, 51284 TLR4, TLR7 na na TGF-β/Smad driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/22981800 Burns 2013 The effect of TLR4/7 on the TGF-β-induced Smad signal transduction pathway in human keloid Jialiang Chen; Biwei Zeng, Hangping Yao, Jinghong Xu na China
23509348 biomarker na miRNA let-7a 406881 MIRLET7A1 na na na suppressor decreased miRNA array  https://pubmed.ncbi.nlm.nih.gov/23509348 J Immunol 2013 The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma Katsunari Makino; Masatoshi Jinnin, Ayaka Hirano, Keitaro Yamane, Mitsuhiko Eto, Takamitsu Kusano, Noritoshi Honda, Ikko Kajihara, Takamitsu Makino, Keisuke Sakai, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn na Japan
23985211 biomarker na protein CASK, ID1 8573, 3397 CASK, ID1 artesunate DB09274 na na na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/23985211 Zhonghua Shao Shang Za Zhi 2013 [Expressions of the related genes in fibroblasts of human keloid and the effect of artesunate] Liang Xiao; Guang-zhao He, Ze-hao Yu, Xiao-qing Tang, Yu-han Ren na China
24043232 biomarker na protein HAS2 3037 HAS2 na na na na na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/24043232 J Burn Care Res 2014 Inhibition of hyaluronan synthase 2 reduces the abnormal migration rate of keloid keratinocytes Dorothy M Supp; Jennifer M Hahn, Kevin L McFarland, Kathryn Glaser na USA
24433185 biomarker na protein MC1R 4157 MC1R na na TGF-β1 suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/24433185 Exp Dermatol 2013 Insufficient expression of the melanocortin-1 receptor by human dermal fibroblasts contributes to excess collagen synthesis in keloid scars Long-Fei Luo; Ying Shi, Qiong Zhou, Shi-Zheng Xu, Tie-Chi Lei MC1R; fibroblast; fibrogenesis; keloid; myofibroblast. China
24335017 biomarker na miRNA MiR-21 100314000 Mir21 na na FasL na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/24335017 Aesthet Surg J 2013 Impact of MiR-21 on the expression of FasL in the presence of TGF-β1 Xiaoxue Wang; Ying Liu, Xi Chen, Miaobo Zhang, Zhibo Xiao FasL; TGF-β1, miR-21; apoptosis; keloid fibroblasts; migration; proliferation; research. China
23709205 biomarker na miRNA microRNA profiling na na na na na na na miRNA array  https://pubmed.ncbi.nlm.nih.gov/23709205 Acta Biochim Biophys Sin (Shanghai) 2013 Comparative study of microRNA profiling in keloid fibroblast and annotation of differential expressed microRNAs Chao Li; Yuehong Bai, Hua Liu, Xuemei Zuo, Haichang Yao, Yiming Xu, Manlin Cao adult dermis; fetal dermis; fibroblasts; keloid; microrna. China
23936604 biomarker na cell melanocytes na na na na na na na PCR, MTT https://pubmed.ncbi.nlm.nih.gov/23936604 Int J Clin Exp Med 2013 The contribution of melanocytes to pathological scar formation during wound healing Fu-Lei Gao; Rong Jin, Lu Zhang, Yu-Guang Zhang Melanocyte; fibroblast; keloid; scar; wound healing. China
22205303 biomarker na protein Histone deacetylase 2 832673 HDA2 na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/22205303 J Invest Dermatol 2012 Histone deacetylase 2 is upregulated in normal and keloid scars Edmund J Fitzgerald O'Connor, Irbaz I Badshah, Lucy Y Addae, Preeya Kundasamy, Sukanthini Thanabalasingam, Daniel Abioye, Mark Soldin, Tanya J Shaw na UK
22188294 biomarker na gene CDC2L1 419406 CDC2L1 na na na na variation DNA sequencing https://pubmed.ncbi.nlm.nih.gov/22188294 Clin Exp Dermatol 2012 Analyses of CDC2L1 gene mutations in keloid tissue G Zhang; J Jiang, S Luo, S Tang, J Liang, P Yao na China
22033527 biomarker na gene HLA-DRB5 3127 HLA-DRB5 na na na na variation qPCR https://pubmed.ncbi.nlm.nih.gov/22033527 Arch Dermatol Res 2012 Comparative genomic hybridisation analysis of keloid tissue in Caucasians suggests possible involvement of HLA-DRB5 in disease pathogenesis Barbara Shih; Ardeshir Bayat Human leukocyte antigen-DRB5; Human leukocyte antigen-DRB1*15; Comparative genomic hybridization; Copy number variation; Copy number alteration; Keloid scars; Keloid disease China
22298115 biomarker na protein CDK10 8558 CDK10 tamoxifen DB00675 na suppressor decreased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/22298115 Molecules 2012 Effects of the cyclin-dependent kinase 10 (CDK10) on the tamoxifen sensitivity of keloid samples Ying Liu; Zhibo Xiao, Daping Yang, Lihong Ren, Guofeng Liu, Lin Yang CDK10; keloid; apoptosis; tamoxifen China
21701945 biomarker na miRNA microRNA profiling na na na na na na na miRNA microarray https://pubmed.ncbi.nlm.nih.gov/21701945 Aesthetic Plast Surg 2012 miRNA expression profiles in keloid tissue and corresponding normal skin tissue Ying Liu; Daping Yang, Zhibo Xiao, Miaobo Zhang na China
22229197 biomarker na protein JNK, ERK 5599, 5594 MAPK8, MAPK1 na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/22229197 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2011 [Experimental study on protein expression of extracellular signal-regulated kinase and c-Jun amino-terminal kinase signaling pathways in keloid fibroblasts] Liu Yong; Ying Cen, Junjie Chen, Dingzi Zhou, Jie Zhang na China
21677671 biomarker na protein TLRs na na na na na na increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/21677671 J Invest Dermatol 2011 Upregulation of Toll-like receptors (TLRs) 6, 7, and 8 in keloid scars Rania A Bagabir, Farhatullah Syed, Riina Rautemaa, Duncan Angus McGrouther, Ralf Paus, Ardeshir Bayat na UK
22259655 biomarker na gene MC1R 4157 MC1R na na na na variation  DNA Sequencing https://pubmed.ncbi.nlm.nih.gov/22259655 Dermatoendocrinol 2011 Reciprocal responses of fibroblasts and melanocytes to α-MSH depending on MC1R polymorphisms Hedwig Stanisz; Markus Seifert, Wolfgang Tilgen, Thomas Vogt, Knuth Rass MC1R polymorphisms; cAMP; fibroblasts; melanocytes; proliferation; α-MSH. Germany
23096718 biomarker na protein KGF 2252 FGF7 na na na driver increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/23096718 J Invest Dermatol 2013 Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis Johanna Canady; Stephanie Arndt; Sigrid Karrer; Anja K Bosserhoff na Germany
23358011 biomarker na protein Hsp27, α2β1-integrin, PAI-2 3315, 3673, 5055 HSPB1, ITGA2, SERPINB2 na na na driver na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/23358011 Plast Reconstr Surg 2013 Up-regulation of tension-related proteins in keloids: knockdown of Hsp27, α2β1-integrin, and PAI-2 shows convincing reduction of extracellular matrix production Edna Suarez; Farhatullah Syed, Teresa Alonso-Rasgado, Parthasarathi Mandal, Ardeshir Bayat na UK
24260741 biomarker na protein hsp70 3308 HSPA4 na na na na increased Proteomic profiling https://pubmed.ncbi.nlm.nih.gov/24260741 Biomed Res Int 2013 Proteomic profiling reveals upregulated protein expression of hsp70 in keloids Ju Hee Lee; Jung U Shin, Inhee Jung, Hemin Lee, Dong Kyun Rah, Jin Young Jung, Won Jai Lee na South Korea
23867793 biomarker na gene TaqI 7421 VDR na na na na variation PCR  https://pubmed.ncbi.nlm.nih.gov/23867793 Cell Physiol Biochem 2013 The TaqI gene polymorphisms of VDR and the circulating 1,25-dihydroxyvitamin D levels confer the risk for the keloid scarring in Chinese cohorts Dongmei Yu; Yong Shang, Sai Luo, Lijun Hao Vitamin D receptor; 25-Hydroxyvitamin D levels; Keloid scar; Risk China
23471552 biomarker na pathway Wnt na na na na na na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/23471552 Int J Med Sci 2013 Identification and characterization of Wnt signaling pathway in keloid pathogenesis Shinichi Igota; Mamiko Tosa, Masahiro Murakami, Seiko Egawa, Hajime Shimizu, Hiko Hyakusoku, Mohammad Ghazizadeh Keloid pathogenesis; ROR2.; Wnt signaling; Wnt5a; frizzled4; wound healing; β-catenin. Japan
22965811 biomarker na miRNA microRNA-7 407043 MIR7-1 na na na suppressor decreased  PCR array https://pubmed.ncbi.nlm.nih.gov/22965811 Arch Dermatol Res 2013 microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma Mitsuhiko Etoh; Masatoshi Jinnin; Katsunari Makino; Keitaro Yamane; Wakana Nakayama; Jun Aoi; Noritoshi Honda; Ikko Kajihara; Takamitsu Makino; Satoshi Fukushima; Hironobu Ihn  Collagen;  Epigenetics;  Fibrosis Japan
23106354 biomarker na cell  B cells, T cells, macrophages, mast cells, Langerhans cells na na na na inflammatory na increased IHC https://pubmed.ncbi.nlm.nih.gov/23106354 Br J Dermatol 2012 Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates R Bagabir; R J Byers, I H Chaudhry, W Müller, R Paus, A Bayat na UK
23259313 biomarker na protein eIF4E, p-eIF4E, Mcl-1 1977, 4170 EIF4E, MCL1 na na na na increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/23259313 Zhonghua Zheng Xing Wai Ke Za Zhi 2012 [Expression and significance of mRNA and protein of eIF4E, p-eIF4E and MCl-1 in pathological scar] Wen-Yi Wu; Li-Ting Zhang, Zhi-Fang Zheng, Shi-Ze Zhu, Zhao-Yang Wang na China
22985040 biomarker na pathway Notch na na na na na driver increased RT-PCR, IHC https://pubmed.ncbi.nlm.nih.gov/22985040 Wound Repair Regen 2012 Notch signaling pathway in keloid disease: enhanced fibroblast activity in a Jagged-1 peptide-dependent manner in lesional vs. extralesional fibroblasts Farhatullah Syed; Ardeshir Bayat na UK
22929264 biomarker na protein Relaxin 6013 RLN1 na na TGF-β/Smad2/3 suppressor na qRT-PCR, IF https://pubmed.ncbi.nlm.nih.gov/22929264 Plast Reconstr Surg 2012 Relaxin-expressing adenovirus decreases collagen synthesis and up-regulates matrix metalloproteinase expression in keloid fibroblasts: in vitro experiments Won Jai Lee; Il-Kyu Choi, Ju Hee Lee, Jung-Sun Lee, Yong Oock Kim, Dong Kyun Rah, Chae-Ok Yun na South Korea
22805880 biomarker na gene TGFβ1, SMAD4 7040, 4089 TGFB1, SMAD4 na na na driver variation PCR https://pubmed.ncbi.nlm.nih.gov/22805880 Arch Dermatol Res 2012 Association of TGFβ1 and SMAD4 variants in the etiology of keloid scar in the Malay population Azadeh Emami; Ahmad Sukari Halim, Iman Salahshourifar, Shah Jumaat Mohd Yussof, Teng Lye Khoo, Thirumulu Ponnuraj Kannan Keloid scar;  Genetic variants;  TGFb1;
SMAD4;  Malay population 		Malaysia
22771320 biomarker na protein TGF-β 7040 TGFB1, SMAD2 na na SMA driver increased atomic force microscopy and confocal microscopy https://pubmed.ncbi.nlm.nih.gov/22771320 J Dermatol Sci 2012 TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin: keloid-derived fibroblasts as a model for cellular mechanics Chih-Hung Lee; Chien-Hui Hong, Ying-Ting Chen, Yu-Chien Chen, Meng-Ru Shen SMA;
TGF-β1;
Cell rigidity;
TGF-β1 receptor;
Keloid 		China
22422640 biomarker na protein SPARC/SFN 6678, 2810 SPARC, SFN na na na suppressor na mass spectroscopy,  co-IP https://pubmed.ncbi.nlm.nih.gov/22422640 J Cell Biochem 2012 SPARC/SFN interaction, suppresses type I collagen in dermal fibroblasts Claudia Chavez-Muñoz; Ryan Hartwell, Reza B Jalili, Seyed Mehdi Jafarnejad, Amy Lai, Layla Nabai, Abdi Ghaffari, Peymon Hojabrpour, Natalia Kanaan, Vincent Duronio, Emma Guns, Artem Cherkasov, Aziz Ghahary EXTRACELLULAR MATRIX; HYPERTROPHIC SCARS; KERATINOCYTE-DERIVED COLLAGEN INHIBITING FACTOR; STRATIFIN; SPARC Canada
22566144 biomarker na gene TGF-β1 7040 TGFB1, SMAD2 na na na na variation SNP analysis https://pubmed.ncbi.nlm.nih.gov/22566144 Arch Dermatol Res 2012 Association of TGFβ1 and clinical factors with scar outcome following melanoma excision Sarah V Ward; G Cadby, J S Heyworth, M W Fear, H J Wallace, J M Cole, F M Wood, L J Palmer Scar outcome;  Non-keloid;  Melanoma;
TGFb1;  Wound repair genes;  Pigmentation; genes 		Australia
22507598 biomarker na protein IFN-I 3439 IFNA1 na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/22507598 Exp Dermatol 2012 Type 1 IFN-induced protein MxA and plasmacytoid dendritic cells in lesions of morphea Mehran Ghoreishi; Cristián Vera Kellet, Jan P Dutz immunohistochemistry; interferon; localized scleroderma;
morphea; plasmacytoid dendritic cell 		Canada
22358059 biomarker na miRNA miR-196a na na na na collagens driver increased miRNA microarray https://pubmed.ncbi.nlm.nih.gov/22358059 J Invest Dermatol 2012 miR-196a downregulation increases the expression of type I and III collagens in keloid fibroblasts Kazuya Kashiyama; Norisato Mitsutake, Michiko Matsuse, Tomoo Ogi, Vladimir A Saenko, Kenta Ujifuku, Atsushi Utani, Akiyoshi Hirano, Shunichi Yamashita na Japan
22050194 biomarker na protein IL-18 3606 IL18 na na na driver increased WB, IHC https://pubmed.ncbi.nlm.nih.gov/22050194 J Invest Dermatol 2012 Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions D V Do; C T Ong, Y T Khoo, A Carbone, C P Lim, S Wang, A Mukhopadhyay, X Cao, D H Cho, X Q Wei, G Bellone, I Lim, T T Phan na Singapore
22295344 biomarker na protein HSP47 871 SERPINH1 na na collagens suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/22295344 Br J Dermatol 2011 Effect of heat shock protein 47 on collagen synthesis of keloid in vivo Jun-Jie Chen; Pei-Sheng Jin, Sha Zhao, Ying Cen, Yong Liu, Xue-Wen Xu, Wei-Qiang Duan, Huai-Sheng Wang collagen, HSP 47, keloid, nude mouse,RNA interference China
21236582 biomarker na protein SIP1 79753 SIP1 na na matrix metalloproteinase suppressor na RT-PCR https://pubmed.ncbi.nlm.nih.gov/21236582 Burns 2011 Smad interacting protein 1 as a regulator of skin fibrosis in pathological scars Zhan-Feng Zhang; Yan-Gang Zhang, Da-Hai Hu, Ji-Hong Shi, Jia-Qi Liu, Zhou-Ting Zhao, Hong-Tao Wang, Xiao-Zhi Bai, Wei-Xia Cai, Hua-Yu Zhu, Chao-Wu Tang Fibrosis
Pathological scar
Smad interacting protein 1
TGFr b1
Collagen
Matrix metalloproteinase 		China
21042181 biomarker na protein IL-24 11009 IL24 na na na suppressor na ELISA https://pubmed.ncbi.nlm.nih.gov/21042181 Ann Plast Surg 2011 Adenovirus-mediated human interleukin 24 (MDA-7/IL-24) selectively suppresses proliferation and induces apoptosis in keloid fibroblasts Jie Liang; Ru-Lin Huang, Qian Huang, Zhi Peng, Pei-Hua Zhang, Zhi-Xian Wu MDA-7/IL-24, proliferation, apoptosis, keloid China
21667528 biomarker na protein Cthrc1 115908 CTHRC1 na na TGF-β1 suppressor increased WB, IHC https://pubmed.ncbi.nlm.nih.gov/21667528 Br J Dermatol 2011 Collagen triple helix repeat containing-1 inhibits transforming growth factor-b1-induced collagen type I expression in keloid J Li; J Cao, M Li, Y Yu, Y Yang, X Xiao, Z Wu, L Wang, Y Tu, H Chen na China
19631342 biomarker na pathway UPR na na hypoxia na na na increased WB  https://pubmed.ncbi.nlm.nih.gov/19631342 Br J Dermatol 2011 Unfolded protein response regulation in keloid cells Paris D Butler; Zhen Wang, Daphne P Ly, Michael T Longaker, Albert C Koong, George P Yang Keloids, Unfolded Protein Response, Wound Healing, Fibroblasts USA
21559318 biomarker na protein family HSP na na na na na na increased WB,ELISA https://pubmed.ncbi.nlm.nih.gov/21559318 J Surg Res 2011 Heat shock proteins modulate keloid formation Serhat Totan; Anthony Echo, Eser Yuksel na USA
21375514 biomarker na protein cav-1 857 CAV1 na na na suppressor increased qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/21375514 Br J Dermatol 2011 Role of caveolin-1 in the pathogenesis of tissue fibrosis by keloid-derived fibroblasts in vitro G-Y Zhang; Q Yu, T Cheng, T Liao, C-L Nie, A-Y Wang, X Zheng, X-G Xie, A E Albers, W-Y Gao na China
21160497 biomarker na protein Rspo2 340419 RSPO2 na na Wnt/β-catenin driver increased WB https://pubmed.ncbi.nlm.nih.gov/21160497 J Invest Dermatol 2011 The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring Alvin W C Chua; Dongrui Ma, Shu U Gan, Zhenying Fu, Hwan C Han, Colin Song, Kanaga Sabapathy, Toan T Phan na Singapore
20642475 biomarker na protein TSG-6 7130 TNFAIP6 hyaluronan DB08818 na na decreased IHC, IF https://pubmed.ncbi.nlm.nih.gov/20642475 J Eur Acad Dermatol Venereol 2011 Characterization of hyaluronan and TSG-6 in skin scarring: differential distribution in keloid scars, normal scars and unscarred skin K T Tan; D A McGrouther, A J Day, C M Milner, A Bayat hyaluronan, inter-α-inhibitor, keloid, scarring, TSG-6 UK
21986318 biomarker na protein NEDD4 4734 NEDD4 na na TGF-β driver na GWAS https://pubmed.ncbi.nlm.nih.gov/21986318 Proc Jpn Acad Ser B Phys Biol Sci 2011 Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production Suyoun Chung; Mitsuko Nakashima, Hitoshi Zembutsu, Yusuke Nakamura na Japan
21792479 biomarker na protein Angiotensin-II 183 AGT, AGTR1 na na nonmuscle myosin II driver na WB, IHC https://pubmed.ncbi.nlm.nih.gov/21792479 Mol Med 2011 Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression Jennifer E Bond; Andrew Bergeron, Peter Thurlow, M Angelica Selim, Edith V Bowers, Anna Kuang, Howard Levinson na USA
21150524 biomarker na protein HGF/c-Met 4233 MET na na na na increased WB, IHC https://pubmed.ncbi.nlm.nih.gov/21150524 J Trauma 2010 The role of hepatocyte growth factor/c-Met system in keloid pathogenesis Anandaroop Mukhopadhyay; Spencer Fan, Vinh D Dang, Audrey Khoo, Chee T Ong, Ivor J Lim, Thang T Phan HGF, c-Met, Fibroblasts, Keloid scar, Keratinocytes, TGF- . Singapore
20872224 biomarker na protein FAP-α 2191 FAP na na na driver increased Flow cytometry, ELISA https://pubmed.ncbi.nlm.nih.gov/20872224 Arch Dermatol Res 2010 Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option Kirstin Dienus; Ardeshir Bayat, Brendan F Gilmore, Oliver Seifert Seprase Keloid Invasion Extracellular matrix Sweden
20547003 biomarker na protein GDF-9 2661 GDF9 na na na na increased gene chip, WB https://pubmed.ncbi.nlm.nih.gov/20547003 Burns 2010 Differential expression of growth differentiation factor-9 in keloids Zhen Gao; Xiaoli Wu, Nan Song, Lu Zhang, Wei Liu GDF-9, Keloid, Invasion, Peripheral area China
20957004 biomarker na protein POSTN 10631 POSTN na na na suppressor na RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/20957004 Beijing Da Xue Xue Bao Yi Xue Ban 2010 [Construction of periostin shRNA vectors and their effects on the expression of periostin in fibroblasts] Chang Liu; Zhen-hua Song, Ze-lian Qin na China
20522201 biomarker na gene HLA-DRB1 3123 HLA-DRB1 na na n na variation PCR https://pubmed.ncbi.nlm.nih.gov/20522201 Tissue Antigens 2010 Association of HLA-DRB1 alleles with keloids in Chinese Han individuals W-S Lu; W-Y Zhang, Y Li, Z-X Wang, X-B Zuo, L-Q Cai, F Zhu, J-F Wang, L-D Sun, X-J Zhang, S Yang haplotype; human leukocyte antigen; human leukocyte antigen-DRB1; keloids; polymerase chain reaction sequence-specific primers China
20100200 biomarker na protein MCP-1 6347 CCL2 na na Akt  driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/20100200 Exp Dermatol 2010 Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids Wei-Ting Liao; Hsin-Su Yu, Jack L Arbiser, Chein-Hui Hong, Baskaran Govindarajan, Chih-Yin Chai, Wan-Ju Shan, Yu-Fen Lin, Gwo-Shing Chen, Chih-Hung Lee Akt, fibroblast proliferation, keloid, MCP-1,
monocytes ⁄ macrophages 		China
19464975 biomarker na protein MMPs na na na na na suppressor na RT-PCR, ELISA https://pubmed.ncbi.nlm.nih.gov/19464975 J Plast Reconstr Aesthet Surg 2010 Matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with different types of scars and keloids Dietmar Ulrich; Franziska Ulrich, Frank Unglaub, Andrzej Piatkowski, Norbert Pallua Hypertrophic scars; Keloids; Matrix metalloproteinases; Tissue inhibitors of metalloproteinases; Wound healing Germany
20386290 biomarker na protein Syndecan-2, decorin 1634 DCN na na na na Increased, ddcreased IHC, WB https://pubmed.ncbi.nlm.nih.gov/20386290 J Trauma 2010 Syndecan-2 and decorin: proteoglycans with a difference--implications in keloid pathogenesis Anandaroop Mukhopadhyay; Man Yi Wong, Sui Y Chan, Dang V Do, Audrey Khoo, Chee T Ong, Han H Cheong, Ivor J Lim, Thang T Phan Syndecan-2, FGF-2, Decorin, Fibroblasts, Keloid Scar, Keratinocytes, TGF- , Epithelial-mesenchymal interactions Singapore
19772524 biomarker na pathway MAPKs na na na na TGF-β1/SMAD na na WB, IF https://pubmed.ncbi.nlm.nih.gov/19772524 Br J Dermatol 2010 Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts S He; X Liu, Y Yang, W Huang, S Xu, S Yang, X Zhang, M S Roberts keloid fibroblasts, mitogen-activated protein kinase, plasminogen activator inhibitor 1, Smad, TGF-b China
20369480 biomarker na protein beta-catenin and Estrogen Receptor 1499, 2099 CTNNB1, ESR1 na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/20369480 Sichuan Da Xue Xue Bao Yi Xue Ban 2010 [Expression of beta-catenin and estrogen receptor in desmoid-type fibromatosis] Hong-Ying Zhang; Qi Ke, Zhang Zhang, Rui Zhang, Jing Fu, Hui-Jiao Chen, Bing Wei, Hong Bu na China
19879246 biomarker na compound chondroitin sulfate na na na na fibulin-5 driver increased IHC, IF https://pubmed.ncbi.nlm.nih.gov/19879246 Biochem Biophys Res Commun 2009 Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid Mika Ikeda; Motoko Naitoh, Hiroshi Kubota, Toshihiro Ishiko, Katsuhiro Yoshikawa, Satoko Yamawaki, Masato Kurokawa, Atsushi Utani, Tomoyuki Nakamura, Kazuhiro Nagata, Shigehiko Suzuki na Japan
20193171 biomarker na protein IFN-γ 3458 IFNG na na TGF-β/Smad suppressor na RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/20193171 Zhonghua Shao Shang Za Zhi 2009 [Effects of interferon-gamma on the transforming growth factor beta/Smad pathway in keloid-derived fibroblasts] Jia-qi Liu; Da-hai Hu, Zhan-feng Zhang, Hao Guan, Tao She, Jun Zhang, Xiao-zhi Bai na China
19907660 biomarker na protein  IL-17/IL-6 3605, 3569 IL17A, IL6 na na na driver na WB, ELISA https://pubmed.ncbi.nlm.nih.gov/19907660 PLoS One 2009 Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis Qunzhou Zhang; Takayoshi Yamaza, A Paul Kelly, Shihong Shi, Songlin Wang, Jimmy Brown, Lina Wang, Samuel W French, Songtao Shi, Anh D Le na USA
25903673 biomarker na protein DDR1 780 DDR1 na na na suppressor increased IHC, WB https://pubmed.ncbi.nlm.nih.gov/25903673 Wounds 2009 The effect of suppressing discoidin domain receptor expression on keloid formation and proliferation Yuzhi Jiang; Xin Xing; Shuliang Lu na China
19224335 biomarker na gene p53 7157 TP53 na na na na variation MTT, Flow cytometry https://pubmed.ncbi.nlm.nih.gov/19224335 Mol Cell Biochem 2009 Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts Bruna De Felice; Corrado Garbi, Margherita Santoriello, Alessandra Santillo, Robert R Wilson Keloids; Hypertrophic scars; Apoptosis;
p53; DNp63; ROS 		Italy
19438747 biomarker na protein MMP-2 4313 MMP2 na na na driver na IF, WB https://pubmed.ncbi.nlm.nih.gov/19438747 Histopathology 2009 Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression Risa Imaizumi; Yoshikiyo Akasaka, Naomi Inomata, Emi Okada, Kinji Ito, Yukio Ishikawa, Yu Maruyama fibroblast, invasion, keloid, MMP-2, MT1-MMP, remodelling, TIMP-2 Japan
18950946 biomarker na protein IL-1β 3553 IL1B na na MMP-1, MMP-2 driver na ELISA https://pubmed.ncbi.nlm.nih.gov/18950946 Burns 2009 Decreased production of MCP-1 and MMP-2 by keloid-derived fibroblasts Fa-Lai Yeh; Horng-Der Shen, Hsiao-Yun Tai Fibroblast
Keloid
MCP-1
MMP-2
TIMP-2 		China
19037237 biomarker na protein Stat3 6774 STAT3 na na na driver increased WB, XTT https://pubmed.ncbi.nlm.nih.gov/19037237 J Invest Dermatol 2009 Cytokine profiling and Stat3 phosphorylation in epithelial-mesenchymal interactions between keloid keratinocytes and fibroblasts Cheh P Lim; Toan T Phan, Ivor J Lim, Xinmin Cao na Singapore
19567073 biomarker na protein SphK1 8877 SPHK1 na na na driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/19567073 Zhonghua Yi Xue Za Zhi 2009 [Expression and function of sphingosine kinases 1 and 2 in human keloid fibroblasts] Jing Zhang; Bin Xu, Zhen-Zhong Liu, Wei Wang, Li-Xia Wang, Ji-Xun Zhang, Jing-Long Cai na China
19165813 biomarker na protein MMP-2, MMP-9 4313, 4318 MMP2, MMP9 na na na na increased ELISA https://pubmed.ncbi.nlm.nih.gov/19165813 Cell Biochem Funct 2009 Matrix metalloproteinase-2 and -9 activities in human keloids, hypertrophic and atrophic scars: a pilot study S Tanriverdi-Akhisaroglu; A Menderes, G Oktay na Turkey
18787533 biomarker na protein HSP20 126393 HSPB6 AZX100 DB06323 na driver na RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/18787533 J Invest Dermatol 2009 Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts Luciana B Lopes; Elizabeth J Furnish, Padmini Komalavilas, Charles R Flynn, Patricia Ashby, Adam Hansen, Daphne P Ly, George P Yang, Michael T Longaker, Alyssa Panitch, Colleen M Brophy na USA
18832570 biomarker na protein PAI-1 5054 SERPINE1 na na na driver na WB https://pubmed.ncbi.nlm.nih.gov/18832570 Am J Pathol 2008 Adenoviral overexpression and small interfering RNA suppression demonstrate that plasminogen activator inhibitor-1 produces elevated collagen accumulation in normal and keloid fibroblasts Tai-Lan Tuan; Paul Hwu, Wendy Ho, Peter Yiu, Richard Chang, Annette Wysocki, Paul D Benya na USA
18562179 biomarker na gene HLA-DQA1、 DQB1 3117, 3119 HLA-DQA1, HLA-DQB1 na na na na variation PCR-SSP https://pubmed.ncbi.nlm.nih.gov/18562179 J Dermatol Sci 2008 Association of HLA-DQA1 and DQB1 alleles with keloids in Chinese Hans Wen-Sheng Lu; Jian-Feng Wang, Sen Yang, Feng-Li Xiao, Cheng Quan, Hui Cheng, Pei-Guang Wang, An-Ping Zhang, Li-Qiong Cai, Xue-Jun Zhang na China
18575776 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na MMPs driver increased IHC, WB https://pubmed.ncbi.nlm.nih.gov/18575776 Int J Mol Med 2008 TGF-beta1 antisense therapy modulates expression of matrix metalloproteinases in keloid-derived fibroblasts H Sadick; A Herberger, K Riedel, G Bran, U Goessler, K Hoermann, F Riedel fibroblasts, keloid, TGFr-ß1,
matrix metalloproteinases 		German
18717361 biomarker na gene RUNX3 864 RUNX3 na na na na variation PCR, DHPLC https://pubmed.ncbi.nlm.nih.gov/18717361 Zhonghua Zheng Xing Wai Ke Za Zhi 2008 [The relationship between RUNX3 gene mutation and keloid] Gang Zhang; Jun-Jian Jiang, Shao-Jun Luo, Shao-ming Tang, Jie Liang, Qian Yu na China
18282266 biomarker na gene expression profile ECM na na na na na na na microarray https://pubmed.ncbi.nlm.nih.gov/18282266 Wound Repair Regen 2008 Identification of unique gene expression patterns within different lesional sites of keloids Oliver Seifert; Ardeshir Bayat, Robert Geffers, Kirstin Dienus, Jan Buer, Sture Löfgren, Andreas Matussek na Sweden
18211495 biomarker na protein IFN-α 3458 IFNG na na na suppressor na recovery https://pubmed.ncbi.nlm.nih.gov/18211495 Int J Dermatol 2008 Effects of interferon-alpha2b on keloid treatment with triamcinolone acetonide intralesional injection June Hyunkyung Lee; Seong Eon Kim, Ai-Young Lee na South Kore
17968183 biomarker na protein CCN2 1490 CCN2 na na na na increased qPCR, WB https://pubmed.ncbi.nlm.nih.gov/17968183 Ann Surg 2007 Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites Wei Xia; Wuyi Kong, Zhen Wang, Toan-Thang Phan, Ivor J Lim, Michael T Longaker, George P Yang na USA
17024100 biomarker na pathway IL-6 3569 IL6 na na na driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/17024100 J Invest Dermatol 2007 Functional implications of the IL-6 signaling pathway in keloid pathogenesis Mohammad Ghazizadeh; Mamiko Tosa, Hajime Shimizu, Hiko Hyakusoku, Oichi Kawanami na Japan
18161363 biomarker na gene p53 7157 TP53 na na na na variation PCR-Rflp https://pubmed.ncbi.nlm.nih.gov/18161363 Zhonghua Zheng Xing Wai Ke Za Zhi 2007 [Association between p53 gene codon 72 polymorphism and keloid in Chinese population] Li Yan; Xiao-yan Lü, Chun-mei Wang, Rui Cao, Yan-hua Yin, Chun-shi Jia, Qiang Zhuang na China
18005590 biomarker na protein Fas 355 FAS na na na suppressor na electronic microscopic examinations https://pubmed.ncbi.nlm.nih.gov/18005590 Zhonghua Wai Ke Za Zhi 2007 [Experimental gene therapy of keloid in vivo using recombinant adenovirus carrying Fas gene] Feng Lu; Jian-Hua Gao na China
17688405 biomarker na protein DeltaNp63 8626 TP63 na na na driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/17688405 DNA Cell Biol 2007 Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts Bruna De Felice; L F Ciarmiello, P Mondola, S Damiano, R Seru, C Argenziano, M Nacca, M Santoriello, C Garbi na Italy
17694658 biomarker na protein p53 7157 TP53 na na telomerase  suppressor na WB, ELISA https://pubmed.ncbi.nlm.nih.gov/17694658 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2007 Effect of wt-P53 protein on telomerase activity in keloid fibroblasts Zhibo Xiao; Lijun Hao, Lihong Ren, Wen Teng na China
17694657 biomarker na gene fas  355 FAS na na na na variation DNA sequencing https://pubmed.ncbi.nlm.nih.gov/17694657 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2007 [Experimental study on fas gene death domain mutations in keloid pedigrees] Xiaojun Liu; Jianhua Gao, Xuelei Li na China
17539964 biomarker na protein FXIIIa 2162 F13A1 na na na driver na IHC https://pubmed.ncbi.nlm.nih.gov/17539964 Pathol Int 2007 Factor XIIIa-positive dermal dendritic cells in keloids and hypertrophic and mature scars Masayuki Onodera; Masaki Ueno, Osamu Ito, Shigehiko Suzuki, Hiroharu H Igawa, Haruhiko Sakamoto dendritic cell, factor XIIIa, immunoelectron microscopy, keloid Japan
17535221 biomarker na protein HSP 47 871 SERPINH1 na na na driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/17535221 Br J Dermatol 2007 Effect of heat shock protein 47 on collagen accumulation in keloid fibroblast cells J-J Chen; S Zhao, Y Cen, X-X Liu, R Yu, D-M Wu collagen, HSP 47, keloid, RNA interference China
17649947 biomarker na protein perios 10631 POSTN na na TGF-β1 na increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/17649947 Zhonghua Zheng Xing Wai Ke Za Zhi 2007 [The expression of periostin in hyperplasic scars and the relations to TGF-beta1 and its receptors] Qi Wang; Fang-Fei Nie, Xia Zhao, Ze-Lian Qin na China
17437482 biomarker na protein mTOR 2475 MTOR na na ECM driver increased WB https://pubmed.ncbi.nlm.nih.gov/17437482 Exp Dermatol 2007 mTOR as a potential therapeutic target for treatment of keloids and excessive scars C T Ong; Y T Khoo, A Mukhopadhyay, D V Do, I J Lim, O Aalami, T T Phan extracellular matrix; keloid; mTOR; p70S6K; rapamycin Singapore
17440345 biomarker na protein Fas 355 FAS na na APOPTOSIS suppressor increased Flow cytometry https://pubmed.ncbi.nlm.nih.gov/17440345 Plast Reconstr Surg 2007 Fas-mediated apoptotic signal transduction in keloid and hypertrophic scar Feng Lu; Jianhua Gao, Rei Ogawa, Hiko Hyakusoku, Chunquan Ou na Japan
16971493 biomarker na protein activin 3624 INHBA na na na driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/16971493 Am J Physiol Cell Physiol 2007 The role of the activin system in keloid pathogenesis Anandaroop Mukhopadhyay; Sui Yung Chan, Ivor J Lim, David J Phillips, Thang T Phan na Singapore
17312486 biomarker na protein connexin 2697 GJA1 na na na na na confocal microscopic analyses https://pubmed.ncbi.nlm.nih.gov/17312486 Plast Reconstr Surg 2007 Variations in gap junctional intercellular communication and connexin expression in fibroblasts derived from keloid and hypertrophic scars Feng Lu; JianHua Gao, Rei Ogawa, Hiko Hyakusoku na China
17178215 biomarker na protein TWEAK 8742 TNFSF12 na na TGF-β suppressor na qPCR https://pubmed.ncbi.nlm.nih.gov/17178215 J Dermatol Sci 2007 TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel Hitoshi Tsuchihashi, Toshio Hasegawa, Koji Sumiyoshi, Hideoki Ogawa, Shigaku Ikeda, Takashi Ando, Atsuhito Nakao, Ko Okumura TWEAK; TGF-b; Fibroblasts; Contraction Japan
17889631 biomarker na protein Smad3 4088 SMAD3 na na collagen driver decreased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/17889631 J Plast Reconstr Aesthet Surg 2007 Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts Zimin Wang; Zhongyu Gao, Yi Shi, Yi Sun, Zihao Lin, Hua Jiang, Tiesheng Hou, Qiugen Wang, Xiangbin Yuan, Xiaohai Zhu, Hong Wu, Youxin Jin RNA interference; Smad3; Keloid; Fibroblast China
17244328 biomarker na protein PGE2 na na na na TGF-β1 suppressor na WB, IF https://pubmed.ncbi.nlm.nih.gov/17244328 Wound Repair Regen 2007 Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-beta1-induced collagen synthesis Vlad C Sandulache; Aron Parekh, HaSheng Li-Korotky, Joseph E Dohar, Patricia A Hebda na USA
17136757 biomarker na protein VEGF 7422 VEGFA na na na na increased ELISA https://pubmed.ncbi.nlm.nih.gov/17136757 J Pathol 2007 Epithelial-mesenchymal interactions in keloid pathogenesis modulate vascular endothelial growth factor expression and secretion C T Ong; Y T Khoo, E K Tan, A Mukhopadhyay, D V Do, H C Han, I J Lim, T T Phan vascular endothelial growth factor; epithelial–mesenchymal interaction;
Rapamycin; WP631; mitoxantrone; keratinocyte; fibroblast 		Singapore
17051103 biomarker na protein  Smad2 4087 SMAD2 na na na driver na RT-PCR, if https://pubmed.ncbi.nlm.nih.gov/17051103 Plast Reconstr Surg 2006 Modulation of collagen synthesis in keloid fibroblasts by silencing Smad2 with siRNA Zhongyu Gao; Zimin Wang, Yi Shi, Zihao Lin, Hua Jiang, Tiesheng Hou, Qiugen Wang, Xiangbin Yuan, Yaozhong Zhao, Hong Wu, Youxin Jin na China
16619044 biomarker na protein Stat3 6774 STAT3 na na Jak2 driver increased IHC, WB https://pubmed.ncbi.nlm.nih.gov/16619044 Oncogene 2006 Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration C P Lim; T-T Phan, I J Lim, X Cao Stat3; keloid; scar; fibroblasts; collagen; migration Singapore
16705627 biomarker na protein CTGF 1490 CCN2 na na na driver increased IHC, WB https://pubmed.ncbi.nlm.nih.gov/16705627 J Cell Physiol 2006 Upregulation of secretory connective tissue growth factor (CTGF) in keratinocyte-fibroblast coculture contributes to keloid pathogenesis Ying Ting Khoo; Chee Tian Ong, Anandaroop Mukhopadhyay, Hwan Chour Han, Dang Vinh Do, Ivor Jiun Lim, Toan Thang Phan na Singapore
16517189 biomarker na protein iNOS 4843 NOS2 na na na driver increased IHC, RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/16517189 Nitric Oxide 2006 Nitric oxide produced by iNOS is associated with collagen synthesis in keloid scar formation Yi-Chiang Hsu; Michael Hsiao, Leng-Fang Wang, Yie W Chien, Woan-Ruoh Lee Keloid; Nitric oxide; Inducible nitric oxide synthase China
16634881 biomarker na protein prolidase 5184 PEPD na na collagen na increased WB https://pubmed.ncbi.nlm.nih.gov/16634881 Br J Dermatol 2006 Elevated prolidase activity in keloids: correlation with type I collagen turnover H S Duong; Q-Z Zhang, A D Le, A P Kelly, R Kamdar, D V Messadi aminoterminal propeptide of type I procollagen, carboxyterminal telopeptide of type I collagen, collagen turnover, keloid, prolidase USA
16528361 biomarker na protein PGE2 na na na na collagen driver decreased IHC, WB https://pubmed.ncbi.nlm.nih.gov/16528361 J Invest Dermatol 2006 Decreased prostaglandin E2 production by inflammatory cytokine and lower expression of EP2 receptor result in increased collagen synthesis in keloid fibroblasts Toshihiko Hayashi; Jun Nishihira, Yoshikazu Koyama, Satoru Sasaki, Yuhei Yamamoto na Japan
16498396 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na na driver increased IHC, WB https://pubmed.ncbi.nlm.nih.gov/16498396 J Invest Dermatol 2006 Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring Anelisa B Campaner; Lydia M Ferreira, Alfredo Gragnani, Jan M Bruder, Jennifer L Cusick, Jeffrey R Morgan na Japan
15606508 biomarker na gene NNP-1 8568 RRP1 na na na driver increased cDNA microarray, in situ hybridization https://pubmed.ncbi.nlm.nih.gov/15606508 Br J Dermatol 2004 Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization G-Y Na; S-K Seo, S-J Lee, D-W Kim, M-K Kim, J-C Kim cDNA microarray, gene, in situ hybridization, keloid, NNP-1 South Korea
15278366 biomarker na pathway NF-κB 4790 NFKB1 na na antiapoptotic genes driver increased cDNA microarrays, IHC, WB https://pubmed.ncbi.nlm.nih.gov/15278366 Arch Dermatol Res 2004 Activation of NFkappaB signal pathways in keloid fibroblasts Diana V Messadi; Hai S Doung, Qhunzhou Zhang, A Paul Kelly, Tai-Lan Tuan, Ernst Reichenberger, Anh D Le Gene expression; Keloid fibroblasts;
NFjB; TNF-a 		USA
16546734 biomarker na protein P38 MAP kinase 1432 MAPK14 na na TGF-β2 na na RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/16546734 Nan Fang Yi Ke Da Xue Xue Bao 2006 [Differential gene expression profile of keloids: a study with cDNA microarray] Zhen-fu Hu; Jian-hua Gao, Wei Li, Yan-bin Song, Chao-long Li na China
16443055 biomarker na protein ACE 1636 ACE na na na driver increased HPLC https://pubmed.ncbi.nlm.nih.gov/16443055 J Am Acad Dermatol 2006 Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin Kiyoshi Morihara; Shinji Takai, Hideya Takenaka, Masato Sakaguchi, Yukiko Okamoto, Toru Morihara, Mizuo Miyazaki, Saburo Kishimoto na Japan
16289155 biomarker na protein HIF-1α 3091 HIF1A Hypoxia na ERK1/2, PI-3K/Akt driver increased WB, IF https://pubmed.ncbi.nlm.nih.gov/16289155 Exp Cell Res 2006 Hypoxia-induced HIF-1 alpha accumulation is augmented in a co-culture of keloid fibroblasts and human mast cells: involvement of ERK1/2 and PI-3K/Akt Qunzhou Zhang; Chad K Oh, Diana V Messadi, Hai S Duong, A Paul Kelly, Chia Soo, Lina Wang, Anh D Le HMC-1; Keloid fibroblasts; Cell – cell interaction; Hypoxia; HIF-1a; ERK1/2; PI-3K/Akt USA
16874413 biomarker na protein TGF-β 7040 TGFB1, SMAD2 na na Wnt/β-catenin driver na IHC, WB https://pubmed.ncbi.nlm.nih.gov/16874413 Acta Derm Venereol 2006 Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids Madoka Sato  na Japan
16676428 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na SMAD6, SMAD7 na na RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/16676428 J Plast Reconstr Aesthet Surg 2006 Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring Haiyan Yu; Oliver Bock, Ardeshir Bayat, Mark W J Ferguson, Ulrich Mrowietz Keloids; SMAD; TGFb; TGFb signalling Germany
16573164 biomarker na gene TbetaR II 7048 TGFBR2 na na na na variation DNA sequencing https://pubmed.ncbi.nlm.nih.gov/16573164 Zhonghua Zheng Xing Wai Ke Za Zhi 2006 [Study on poly A site gene mutation of transforming growth factor-beta1 receptor type II between multiple and single site keloid] Jing-long Cai; Gang An, Bin Xu, Gui-ying Zhu, Shu-qiang Fan, Hong-shan Yan na China
16217483 biomarker na protein TGF-β 7040 TGFB1, SMAD2 na na CTGF driver na RT-PCR https://pubmed.ncbi.nlm.nih.gov/16217483 Plast Reconstr Surg 2005 Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation Amy S Colwell; Toan-Thang Phan, Wuyi Kong, Michael T Longaker, Peter H Lorenz na USA
16184401 biomarker na protein TGF-beta1, VEGF 7040, 7422 TGFB1, VEGFA na na na driver increased WB, ELISA https://pubmed.ncbi.nlm.nih.gov/16184401 Arch Dermatol Res 2005 Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor in cultured keloid fibroblasts: relevance to angiogenic activity Masao Fujiwara; Yasuteru Muragaki, Akira Ooshima Vascular endothelial growth
factor; TGFr-b1;
Angiogenesis; Keloids; In vivo model 		Japan
16052471 biomarker na protein Smad3 4088 SMAD3 na na na driver na WB https://pubmed.ncbi.nlm.nih.gov/16052471 J Pathol 2005 Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions T T Phan; I J Lim, O Aalami, F Lorget, A Khoo, E K Tan, A Mukhopadhyay, M T Longaker keloid; wound healing; keratinocytes; fibroblasts; co-culture Singapore
16043141 biomarker na gene TGF-β3 7043 TGFB3 na na na no effect variation DHPLC mutation detection https://pubmed.ncbi.nlm.nih.gov/16043141 Br J Plast Surg 2005 Genetic susceptibility to keloid disease: mutation screening of the TGFbeta3 gene A Bayat; J M Walter, O Bock, U Mrowietz, W E R Ollier, M W J Ferguson Keloid disease/scarring; TGFr β three; Mutation detection; Polymorphisms; Genetics UK
16130386 biomarker na protein Hsp47 871 SERPINH1 na na na na increased qRT-PCR https://pubmed.ncbi.nlm.nih.gov/16130386 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2005 [Detection of expression of heat shock protein 47 mRNA in pathological scar tissue by using real-time fluorescent quantitative RT-PCR] Junjie Chen; Ying Cen na China
15788485 biomarker na protein Etk/Bmx 660 BMX na na VEGF，PAI-1, iNOS na increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/15788485 Am J Physiol Cell Physiol 2005 Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems Cindy H Chau; Carlos A Clavijo, Hong-Tao Deng, Qunzhou Zhang, Kwang-Jin Kim, Yun Qiu, Anh D Le, David K Ann inducible nitric oxide synthase; apoptosis; nuclear factor-B USA
16008726 biomarker na protein caspase-9 842 CASP9 na na caspase-3 suppressor increased IHC  https://pubmed.ncbi.nlm.nih.gov/16008726 Wound Repair Regen 2005 Activated caspase expression and apoptosis increase in keloids: cytochrome c release and caspase-9 activation during the apoptosis of keloid fibroblast lines Yoshikiyo Akasaka; Kinji Ito, Kazuko Fujita, Kazuo Komiyama, Ichiro Ono, Yukio Ishikawa, Yuri Akishima, Hiroko Sato, Toshiharu Ishii na Japan
16045028 biomarker na protein HO-1 3162 HMOX1 na na na driver increased IHC https://pubmed.ncbi.nlm.nih.gov/16045028 Zhong Nan Da Xue Xue Bao Yi Xue Ban 2005 [Relationship between angiogenesis and expression of HO-1 of scar] Jie Zhu; Cheng-Qun Luo, Quan-Yong He, Hao Peng, Jian-Da Zhou, Ping Li na China
15816827 biomarker na protein IL-6 3569 IL6 na na na na na cDNA microarray https://pubmed.ncbi.nlm.nih.gov/15816827 J Invest Dermatol 2005 Global gene expression analysis of keloid fibroblasts in response to electron beam irradiation reveals the involvement of interleukin-6 pathway Mamiko Tosa; Mohammad Ghazizadeh, Hajime Shimizu, Takashi Hirai, Hiko Hyakusoku, Oichi Kawanami  cDNA microarray; electron beam irradiation; gene expression; IL-6 pathway; IL-6 receptor; keloid fibroblast; non-lesional dermal fibroblast Japan
15906547 biomarker na protein MMP-1 4312 MMP1 sphingosine DB03203 na na increased WB https://pubmed.ncbi.nlm.nih.gov/15906547 J Dermatol 2005 An increase of MMP-1 is stimulated by sphingosine in keloid fibroblasts Sung-Eun Chang, Mi-Woo Lee, Kee-Chan Moon, Jee-Hoi Choi, Jai-Kyoung Koh MMP-1; sphingosine; keloid fibroblasts South Korea
12160532 biomarker na gene TGF-β2 7042 TGFB2 na na na na variation qPCT https://pubmed.ncbi.nlm.nih.gov/12160532 Br J Plast Surg 2002 Genetic susceptibility to keloid disease and transforming growth factor beta 2 polymorphisms A Bayat; O Bock, U Mrowietz, W E R Ollier, M W J Ferguson keloid disease, hypertrophic scarring, TGFr [32, polymorphism, genetics.  UK
15248062 biomarker na gene p63 8626 TP63 na na na na variation RT-PCR https://pubmed.ncbi.nlm.nih.gov/15248062 Mol Genet Genomics 2004 Molecular characterization and expression of p63 isoforms in human keloids B De Felice; R R Wilson, M Nacca, L F Ciarmiello, C Pinelli Keloids; p63 isoforms; RNA splicing Italy
15568749 biomarker na protein cyclin D1, p16 595, 1029 CCND1, CDKN2A na na na driver increased IHC https://pubmed.ncbi.nlm.nih.gov/15568749 Zhonghua Zheng Xing Wai Ke Za Zhi 2004 [The expression and interaction of cyclin D1 and p16 in fibroblasts of pathologic scars] Jia-Feng Liu; Yi-Ming Zhang, Chuan-Xun Yi, Jia-Ming Sun, Wei-Wei Li na China
15296939 biomarker na protein lysyl hydroxylases na na na na pyridinoline cross-links driver increased RT-PCR https://pubmed.ncbi.nlm.nih.gov/15296939 Matrix Biol 2004 Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon Annemarie J van der Slot; Anne-Marie Zuurmond, Antoon J van den Bogaerdt, Magda M W Ulrich, Esther Middelkoop, Willem Boers, H Karel Ronday, Jeroen DeGroot, Tom W J Huizinga, Ruud A Bank Fibrosis; Pyridinoline cross-links; Telopeptide lysyl hydroxylase Netherlands
15153883 biomarker na protein VEGF 7422 VEGFA na na na driver increased situ hybridization https://pubmed.ncbi.nlm.nih.gov/15153883 J Am Acad Dermatol 2004 Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor Amy Kim Gira; Lawrence F Brown, Carl V Washington, Cynthia Cohen, Jack L Arbiser na USA
15312469 biomarker na gene p53 7157 TP53 na na na na mutation PCR-SSCP https://pubmed.ncbi.nlm.nih.gov/15312469 Zhonghua Shao Shang Za Zhi 2004 [Experimental study on p53 gene mutation in keloid fibroblasts] Wang Liu; You-Hui Jiang, You-Liang Li, Zi-Hao Lin, Hua Jiang, Qian Tan, Jian-Lin Zhang, Zi-Min Wang na China
15312467 biomarker na protein Tn-C 3371 TNC na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/15312467 Zhonghua Shao Shang Za Zhi 2004 [Study on the expression of tenascin-C in keloid and hyperplastic scar] Xiao-Jie He; Chun-Mao Han na China
14978738 biomarker na protein PAI-1 5054 SERPINE1 hypoxia na na driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/14978738 J Cell Physiol 2004 Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts Qunzhou Zhang; Yidi Wu, Cindy H Chau, David K Ann, Charles N Bertolami, Anh D Le na USA
14644771 biomarker na protein VEGF 7422 VEGFA na na ERK1/2 driver increased RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/14644771 Am J Physiol Cell Physiol 2004 Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts Yidi Wu; Qunzhou Zhang, David K Ann, Anita Akhondzadeh, Hai S Duong, Diana V Messadi, Anh D Le urokinase plasminogen activator; extracellular matrix; fibrosis USA
14984576 biomarker na protein HSP47 871 SERPINH1 na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/14984576 J Cutan Pathol 2004 HSP47 is a useful marker for skin fibroblasts in formalin-fixed, paraffin-embedded tissue specimens K Kuroda; S Tajima na Japan
15009106 biomarker na gene TGF-β  7040 TGFB1, SMAD2 na na na na variation PCR https://pubmed.ncbi.nlm.nih.gov/15009106 Exp Dermatol 2004 Genetic susceptibility to keloid disease: transforming growth factor beta receptor gene polymorphisms are not associated with keloid disease Ardeshir Bayat; O Bock, U Mrowietz, W E R Ollier, M W J Ferguson genetics; keloid disease/ scarring; polymorphisms; TGFr b receptors UK
14757278 biomarker na protein p53 7157 TP53 na na na na increased WB https://pubmed.ncbi.nlm.nih.gov/14757278 J Dermatol Sci 2004 Expression of p53 family in scars Aya Tanaka; Mitsuo Hatoko, Hideyuki Tada, Hiroshi Iioka, Katsunori Niitsuma, Sachiko Miyagawa Human skin; Scar; p53family Japan
14675177 biomarker na cell Keratinocytes na na na na apoptosis driver na WB https://pubmed.ncbi.nlm.nih.gov/14675177 J Invest Dermatol 2003 Keratinocytes promote proliferation and inhibit apoptosis of the underlying fibroblasts: an important role in the pathogenesis of keloid Emi Funayama; Thinle Chodon, Akihiko Oyama, Tsuneki Sugihara na Japan
12907681 biomarker na pathway ERK, PI3K na na na na na driver na WB https://pubmed.ncbi.nlm.nih.gov/12907681 J Biol Chem 2003 Synchronous activation of ERK and phosphatidylinositol 3-kinase pathways is required for collagen and extracellular matrix production in keloids Ivor J Lim; Toan-Thang Phan, Ee-Kim Tan, Thi-Thanh T Nguyen, Evelyne Tran, Michael T Longaker, Colin Song, Seng-Teik Lee, Hung-The Huynh na Singapore
14628411 biomarker na gene p53 7157 TP53 na na na na variation  PCR-SSCP https://pubmed.ncbi.nlm.nih.gov/14628411 Zhonghua Zheng Xing Wai Ke Za Zhi 2003 [Investigation of p53 gene mutations in keloids using PCR-SSCP] Yong-bo Liu; Jian-hua Gao, Hong-jie Duan, Xiao-jun Liu na China
12788525 biomarker na protein IFN-γ 3458 IFNG na na TGF-β  no effect na WB, IF https://pubmed.ncbi.nlm.nih.gov/12788525 J Dermatol Sci 2003 IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts Toshio Hasegawa; Atsuhito Nakao, Koji Sumiyoshi, Ryoji Tsuboi, Hideoki Ogawa IFN-g; TGF-b; Fibroblasts; Keloid Japan
12787120 biomarker na protein Insulin-like growth factor-I 3480 IGF1R na na transcription factor-2 driver na WB, RT-PCR https://pubmed.ncbi.nlm.nih.gov/12787120 J Invest Dermatol 2003 Insulin-like growth factor-I enhances transforming growth factor-beta-induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts Takehiro Daian; Akira Ohtsuru, Tatiana Rogounovitch, Hiroshi Ishihara, Akiyoshi Hirano, Yuri Akiyama-Uchida, Vladimir Saenko, Tohru Fujii, Shunichi Yamashita na Japan
12707042 biomarker na protein PAI-1 5054 SERPINE1 na na na driver increased IHC, Northern blot https://pubmed.ncbi.nlm.nih.gov/12707042 Am J Pathol 2003 Increased plasminogen activator inhibitor-1 in keloid fibroblasts may account for their elevated collagen accumulation in fibrin gel cultures Tai-Lan Tuan; Huayang Wu, Eunice Y Huang, Sheree S N Chong, Walter Laug, Diana Messadi, Paul Kelly, Anh Le na USA
12620890 biomarker na protein IGFs na na na na na driver na MTT, WB https://pubmed.ncbi.nlm.nih.gov/12620890 Am J Physiol Cell Physiol 2003 Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro Toan-Thang Phan; Ivor Jiun Lim, Boon Huat Bay, Robert Qi, Michael Thornton Longaker, Seng-Teik Lee, Hung Huynh insulin-like growth factor; coculture Singapore
12651236 biomarker na protein Fas  355 FAS na na na na decreased IHC  https://pubmed.ncbi.nlm.nih.gov/12651236 Di Yi Jun Yi Da Xue Xue Bao 2003 Immunohistochemical analysis of Fas protein expression in hypertrophic scar and keloid Feng Lu; Jian-hua Gao, Xiao-jian Li na China
12087300 biomarker na protein Thrombospondin-1 7057 THBS1 na na matrix-associated plasminogen/plasmin system driver na IF, ELISA https://pubmed.ncbi.nlm.nih.gov/12087300 Plast Reconstr Surg 2002 Thrombospondin-1 may modulate keloid formation through up-regulation of the matrix-associated plasminogen/plasmin system Robert F Centeno, Daniel Albo, Vicki L Rothman, Mark S Granick, George P Tuszynski na USA
11838052 biomarker na protein TNF-α 21926 Tnf na na na suppressor na WB https://pubmed.ncbi.nlm.nih.gov/11838052 Zhonghua Zheng Xing Wai Ke Za Zhi 2001 [Response of keloid fibroblasts to the effect of tumor necrosis factor-alpha(TNF-alpha)] W He; R Liu, B Zhong na China
11762221 biomarker na protein Bcl-2, Fas 596, 355 BCL2, FAS na na na na na IHC https://pubmed.ncbi.nlm.nih.gov/11762221 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2001 [Experimental study of Bcl-2 and Fas gene expression in fibroblast of scar] Y Liu; L S Ren, Y Cen na China
11496185 biomarker na protein TGF-β1, TGF-β2, Smad 3 7057, 7042, 4088 THBS1, TGFB2, SMAD3 na na na driver increased WB https://pubmed.ncbi.nlm.nih.gov/11496185 Plast Reconstr Surg 2001 Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts G S Chin; W Liu, Z Peled, T Y Lee, D S Steinbrech, M Hsu, M T Longaker na USA
11162672 biomarker na protein HSP47, collagen type III 871, 1281 SERPINH1, COL3A1 na na na driver increased Northern blot, WB https://pubmed.ncbi.nlm.nih.gov/11162672 Biochem Biophys Res Commun 2001 Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid M Naitoh; N Hosokawa, H Kubota, T Tanaka, H Shirane, M Sawada, Y Nishimura, K Nagata na Japan
11304607 biomarker na cell keloid-derived keratinocytes na na na na na driver na MTT https://pubmed.ncbi.nlm.nih.gov/11304607 Plast Reconstr Surg 2001 Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro I J Lim; T T Phan, C Song, W T Tan, M T Longaker na Singapore
11121143 biomarker na compound compound na na na na apoptosis suppressor na IF, TUNEL, flow cytometric analysis, WST-1 https://pubmed.ncbi.nlm.nih.gov/11121143 J Invest Dermatol 2000 Keloid fibroblasts resist ceramide-induced apoptosis by overexpression of insulin-like growth factor I receptor H Ishihara; H Yoshimoto, M Fujioka, R Murakami, A Hirano, T Fujii, A Ohtsuru, H Namba, S Yamashita na Japan
11073825 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na Fas suppressor na IF, WB https://pubmed.ncbi.nlm.nih.gov/11073825 Am J Pathol 2000 Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance T Chodon; T Sugihara, H H Igawa, E Funayama, H Furukawa na Japan
12516475 biomarker na protein PDGFR-β 5159 PDGFRB na na na driver decreased low cytometric analysis, IHC https://pubmed.ncbi.nlm.nih.gov/12516475 Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2000 [Expression of platelet derived growth factor receptor-beta in fibroblasts of keloid] Q X Shang; R Yuan, W Wang na China
10739667 biomarker na protein SLPI 6590 SLPI na na na suppressor na IF, WB https://pubmed.ncbi.nlm.nih.gov/10739667 Exp Cell Res 2000 Secretory leukocyte protease inhibitor is a novel inhibitor of fibroblast-mediated collagen gel contraction Y Sumi; H Muramatsu, K Hata, M Ueda, T Muramatsu na Japan
10890181 biomarker na protein IGF-I 3479 IGF1 na na na driver increased IHC https://pubmed.ncbi.nlm.nih.gov/10890181 Endocr J 2000 Insulin-like growth factor-I (IGF-I)/IGF-I receptor axis and increased invasion activity of fibroblasts in keloid A Ohtsuru; H Yoshimoto, H Ishihara, H Namba, S Yamashita IGF-I, IGF-I Receptor, Fibroblast Japan
10744070 biomarker na protein caspase-3 836 CASP3 na na na suppressor increased IHC https://pubmed.ncbi.nlm.nih.gov/10744070 Lab Invest 2000 Enhanced expression of caspase-3 in hypertrophic scars and keloid: induction of caspase-3 and apoptosis in keloid fibroblasts in vitro Y Akasaka; Y Ishikawa, I Ono, K Fujita, T Masuda, N Asuwa, K Inuzuka, H Kiguchi, T Ishii na Japan
10720455 biomarker na protein IL-6 3569 IL6 na na na na increased Ribonuclease protection assay, ELISA https://pubmed.ncbi.nlm.nih.gov/10720455 J Surg Res 2000 Elevated interleukin-6 expression in keloid fibroblasts H Xue; R L McCauley, W Zhang keloids; fibroblasts; interleukin-6; interferon g. USA
10688614 biomarker na protein IL-13 3596 IL13 na na collagen driver na ELISA, WB https://pubmed.ncbi.nlm.nih.gov/10688614 J Pharmacol Exp Ther 2000 Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts A Oriente; N S Fedarko, S E Pacocha, S K Huang, L M Lichtenstein, D M Essayan na USA
10633011 biomarker na protein TGF-β2 7042 TGFB2 na na collagen driver na IHC https://pubmed.ncbi.nlm.nih.gov/10633011 Wound Repair Regen 1999 Expression of apoptosis-associated genes by human dermal scar fibroblasts D V Messadi; A Le, S Berg, A Jewett, Z Wen, P Kelly, C N Bertolami na USA
10816659 biomarker na protein POMC 5443 POMC tranilast DB07615 na driver na Northern blot, WB https://pubmed.ncbi.nlm.nih.gov/10816659 Ann N Y Acad Sci 1999 POMC and fibroblast biology T Lotti; P Teofoli, B Bianchi, A Mauviel na Italy
10469311 biomarker na protein type XVI collagen 1307 COL16A1 na na na driver increased IHC, IF https://pubmed.ncbi.nlm.nih.gov/10469311 J Invest Dermatol 1999 Expression of type XVI collagen in human skin fibroblasts: enhanced expression in fibrotic skin diseases A Akagi; S Tajima, A Ishibashi, N Yamaguchi, Y Nagai na Japan
10454326 biomarker na protein TGF-β2, TGF-β1 7040, 7042 TGFB1, TGFB2 na na na driver increased WB https://pubmed.ncbi.nlm.nih.gov/10454326 Ann Plast Surg 1999 Expression of transforming growth factor beta 1, 2, and 3 proteins in keloids T Y Lee; G S Chin, W J Kim, D Chau, G K Gittes, M T Longaker na USA
11593607 biomarker na protein TGF-β1, type I, III procollagen na na na na na driver increased Dot-blot hybridization analysis https://pubmed.ncbi.nlm.nih.gov/11593607 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 1999 [Changes in TGF-beta 1 and type I, III procollagen gene expression in keloid and hypertrophic scar] S Tang; S Pang, Y Cao na China
10417515 biomarker na protein tenascin C 3371 TNC na na na na increased IHC https://pubmed.ncbi.nlm.nih.gov/10417515 Br J Dermatol 1999 Increased expression of tenascin C by keloids in vivo and in vitro A Dalkowski; D Schuppan, C E Orfanos, C C Zouboulis collagen XIV, extracellular matrix glycoprotein, ®bronectin, keloids, tenascin C, undulin Germany
10222156 biomarker na protein PAI-1 5054 SERPINE1 na na na na increased Northern blot https://pubmed.ncbi.nlm.nih.gov/10222156 Exp Cell Res 1999 Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype P J Higgins; J K Slack, R F Diegelmann, L Staiano-Coico na USA
10090846 biomarker na protein TGF-β2 7042 TGFB2 na na na driver na FPCL https://pubmed.ncbi.nlm.nih.gov/10090846 J Surg Res 1999 TGF-beta2 activates proliferative scar fibroblasts P Smith; G Mosiello, L Deluca, F Ko, S Maggi, M C Robson na USA
10079266 biomarker na protein IGF-IR 3480 IGF1R na na na driver increased IHC https://pubmed.ncbi.nlm.nih.gov/10079266 Am J Pathol 1999 Overexpression of insulin-like growth factor-1 (IGF-I) receptor and the invasiveness of cultured keloid fibroblasts H Yoshimoto; H Ishihara, A Ohtsuru, K Akino, R Murakami, H Kuroda, H Namba, M Ito, T Fujii, S Yamashita na Japan
10452075 biomarker na mRNA I, III procollagen na na na na na na increased situ hybridization https://pubmed.ncbi.nlm.nih.gov/10452075 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 1998 [Study on in situ expression of type I and III procollagen mRNAs in different parts of keloid and normal skin] W Bao; S Xu, B Guan na China
9722726 biomarker na gene p53 7157 TP53 na na na na variation PCR-SSCP https://pubmed.ncbi.nlm.nih.gov/9722726 Arch Dermatol 1998 Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing G M Saed; D Ladin, J Olson, X Han, Z Hou, D Fivenson na USA
9450987 biomarker na protein TGF-β1 7040 TGFB1, SMAD2 na na PDGF-αR na na Northern blot, WB https://pubmed.ncbi.nlm.nih.gov/9450987 Front Biosci 1998 Effect of TGF-beta 1 on PDGF receptors expression in human scar fibroblasts D V Messadi; A Le, S Berg, G Huang, W Zhuang, C N Bertolami na USA
8948610 biomarker na protein IFN-γ 3458 IFNG na na na suppressor na recurrence https://pubmed.ncbi.nlm.nih.gov/8948610 Laryngoscope 1996 Keloid excision and recurrence prophylaxis via intradermal interferon-gamma injections: a pilot study B J Broker; D Rosen, J Amsberry, R Schmidt, L Sailor, E A Pribitkin, W M Keane na USA
8823022 biomarker na protein TGF-β 7040 TGFB1, SMAD2 na na na driver na Northern blot https://pubmed.ncbi.nlm.nih.gov/8823022 Plast Reconstr Surg 1996 The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesis D A Bettinger; D R Yager, R F Diegelmann, I K Cohen na USA
8618030 biomarker na protein PAI-1 5054 SERPINE1 na na fibrinolysis driver increased Northern blot https://pubmed.ncbi.nlm.nih.gov/8618030 J Invest Dermatol 1996 Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts T L Tuan; J Y Zhu, B Sun, L S Nichter, M E Nimni, W E Laug na USA
7829880 biomarker na compound glucocorticoid na na na na elastin no effect na Northern blot https://pubmed.ncbi.nlm.nih.gov/7829880 J Invest Dermatol 1995 Glucocorticoid regulation of elastin synthesis in human fibroblasts: down-regulation in fibroblasts from normal dermis but not from keloids S B Russell; J S Trupin, R Z Kennedy, J D Russell, J M Davidson na USA
7930682 biomarker na protein PDGF na na na na na suppressor na immunoprecipitation https://pubmed.ncbi.nlm.nih.gov/7930682 J Invest Dermatol 1994 Elevated levels of PDGF alpha receptors in keloid fibroblasts contribute to an enhanced response to PDGF M Haisa; H Okochi, G R Grotendorst na USA
7979045 biomarker na protein TGF-β 7040 TGFB1, SMAD2 na na collagen driver na Northern blot https://pubmed.ncbi.nlm.nih.gov/7979045 Ann Plast Surg 1994 Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblasts S Younai; L S Nichter, T Wellisz, J Reinisch, M E Nimni, T L Tuan na USA
17147705 biomarker na protein TGF-α2b 3439 IFNA1 na na na suppressor na gel contraction https://pubmed.ncbi.nlm.nih.gov/17147705 Wound Repair Regen 1993 Suppression of in vitro proliferative scar fibroblast contraction by interferon alfa-2b K Sahara; A Kucukcelebi, F Ko, L Phillips, M Robson na USA
7679551 biomarker na protein Acidic and basic fibroblast growth factors na na na na collagen suppressor na IF, slot-blot https://pubmed.ncbi.nlm.nih.gov/7679551 Am J Pathol 1993 Acidic and basic fibroblast growth factors down-regulate collagen gene expression in keloid fibroblasts E M Tan; S Rouda, S S Greenbaum, J H Moore Jr, J W Foxth, S Sollberg na USA
1431230 biomarker na protein TGF-β 7040 TGFB1, SMAD2 na na na driver na SDS-PAGE https://pubmed.ncbi.nlm.nih.gov/1431230 J Invest Dermatol 1992 Keloid fibroblasts exhibit an altered response to TGF-beta M Babu; R Diegelmann, N Oliver na USA
1898372 biomarker na protein ECGF, heparin 2246 FGF1 na na collagen suppressor na IF, slot-blot https://pubmed.ncbi.nlm.nih.gov/1898372 Biochem J 1991 Endothelial cell growth factor and heparin regulate collagen gene expression in keloid fibroblasts E M Tan; J Peltonen na USA
1911567 biomarker na protein collagen na na na na na driver increased situ hybridization https://pubmed.ncbi.nlm.nih.gov/1911567 J Dermatol Sci 1991 Collagen mRNA expression detected by in situ hybridization in keloid tissue K S Lee; J Y Song, M H Suh Procollagen mRNA; Keloid; In situ hybridization South Korea
22358773 biomarker na protein PDGF na na na na fibronectin na na radioimmunoprecipitation https://pubmed.ncbi.nlm.nih.gov/22358773 Cytotechnology 1990 Effects of platelet derived growth factor (PDGF) on fibronectin (FN) production by human skin and scar fibroblasts C W Kischer; J Pindur cultured cells, fibronectin, hypertrophic scar, keloid, platelet derived growth factor USA
2630174 biomarker na protein fibronectin 2335 FN1 na na na na increased micro Lowry https://pubmed.ncbi.nlm.nih.gov/2630174 Connect Tissue Res 1989 Increased fibronectin production by cell lines from hypertrophic scar and keloid C W Kischer; H N Wagner Jr, J Pindur, H Holubec, M Jones, J B Ulreich, P Scuderi Cultured cells, fibronectin, skin, enzyme-linked immunosorbent assay, fibroblast, hypertrophic scar USA
3862108 biomarker na protein procollagen na na na na na na increased dot-blot, RNA transfer hybridizations https://pubmed.ncbi.nlm.nih.gov/3862108 Proc Natl Acad Sci U S A 1985 Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts J Uitto, A J Perejda, R P Abergel, M L Chu, F Ramirez na USA
1703584 biomarker na protein type I procollagen 1277 COL1A1 na na na na increased situ hybridization, WB https://pubmed.ncbi.nlm.nih.gov/1703584 Lab Invest 1991 Combined use of in situ hybridization and unlabeled antibody peroxidase anti-peroxidase methods: simultaneous detection of type I procollagen mRNAs and factor VIII-related antigen epitopes in keloid tissue S Sollberg; J Peltonen, J Uitto na USA
2121104 biomarker na protein IFN-γ 3458 IFNG na na na suppressor na recurrence https://pubmed.ncbi.nlm.nih.gov/2121104 Arch Dermatol 1990 A controlled trial of intralesional recombinant interferon-gamma in the treatment of keloidal scarring. Clinical and histologic findings R D Granstein; A Rook, T J Flotte, A Haas, R L Gallo, H S Jaffe, E P Amento na USA
2553784 biomarker na protein TGF-α2b 3439 IFNA1 na na na suppressor na recurrence https://pubmed.ncbi.nlm.nih.gov/2553784 J Am Acad Dermatol 1989 Short-term keloid treatment in vivo with human interferon alfa-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro B Berman; M R Duncan na USA
65777 biomarker na protein α-globulins na na na na na driver na cell growth https://pubmed.ncbi.nlm.nih.gov/65777 Plast Reconstr Surg 1977 Tissue alpha-globulins in keloid formation R F Diegelmann, C P Bryant, I K Cohen na USA

Drug

PMID Type Therapy BiomarkerType Biomarker Gene ID Symbol Drug DrugBank ID Target suppressor/driver Expression DetectingTechniques Url Journal Year Title Authors Keywords Country
36005946 drug na drug na na na Glabridin na PI3K/Akt and TGFβ1/SMAD suppressor na inflammation, and collagen https://pubmed.ncbi.nlm.nih.gov/36005946 J Agric Food Chem 2022 Glabridin from Glycyrrhiza glabra Possesses a Therapeutic Role against Keloid via Attenuating PI3K/Akt and Transforming Growth Factor-β1/SMAD Signaling Pathways Qing Zhang; Die Qian; Dan-Dan Tang; Jia Liu; Lin-Yu Wang; Wenwen Chen; Chun-Jie Wu; Wei Peng  Glycyrrhiza glabra; PI3K/Akt; TGF-β1/SMAD; apoptosis; glabridin; keloid. China
35871490 drug na drug na na na bleomycin, triamcinolone DB00290, DB00620 na suppressor na Japan scar workshop, Japan scar scale https://pubmed.ncbi.nlm.nih.gov/35871490 Dermatol Ther 2022 Intralesional bleomycin versus intralesional triamcinolone in the treatment of keloids and hypertrophic scars Hamideh Moravej; Ali Forghanian; Sahar Dadkhahfar; Nikoo Mozafari bleomycin; cryotherapy; keloid; triamcinolone. Iran
35842750 drug na drug na na na bleomycin DB00290 na suppressor na vss https://pubmed.ncbi.nlm.nih.gov/35842750 J Cosmet Dermatol 2022 Keloid therapy: A neoteric comparative study Fathia M Khattab; Hagar Bessar; Elsayed M Khater  bleomycin; cryotherapy; intralesional; keloids. Egypt
35774378 drug na na Hydrogen Sulfide na na na na Oxidative Stress, Necroptosis suppressor na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35774378 Oxid Med Cell Longev 2022 Hydrogen Sulfide Suppresses Skin Fibroblast Proliferation via Oxidative Stress Alleviation and Necroptosis Inhibition Ling Li; Ziying He; Yue Zhu; Qiyan Shen; Shengju Yang; Shuanglin Cao  na China
35802302 drug na drug na na na sunitinib DB01268 Akt/PI3K/mTOR suppressor na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/35802302 Apoptosis 2022 Targeting the Akt/PI3K/mTOR signaling pathway for complete eradication of keloid disease by sunitinib Yiqing Chen; Chunlin Chen; Junren Fang; Kui Su; Qian Yuan; Huan Hou; Huijuan Xin; Jianwu Sun; Chaohong Huang; Shuyi Li; Zhengqiang Yuan; Shengkang Luo Akt/PI3K/mTOR pathway; Keloid; Keloid explant model; Keloid fibroblasts; Sunitinib. China
35838528 drug na drug na na na Dihydroartemisinin DB11638 na suppressor na RNA-SEQ https://pubmed.ncbi.nlm.nih.gov/35838528 Chin Med J (Engl) 2022 Dihydroartemisinin-induced mitochondrial mRNA degradation and apoptosis in keloid fibroblasts Qijie Li; Ping Wu; Yiqing Xia; Dunshui Liao; Yunxia Zuo; Junliang Wu; Qingjie Xia na China
34439906 drug na drug na na na pinocembrin na TGF-β1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34439906 Biomolecules 2021 Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF-β1 Signaling Pathway Xiaohe Li; Yunqian Zhai; Buri Xi; Wei Ma; Jianwei Zhang; Xiaoyang Ma; Yang Miao; Yongjian Zhao; Wen Ning; Honggang Zhou; Cheng Yang TGF-β1 signaling; fibroblasts; keloid; pinocembrin; skin fibrosis. China
33237588 drug na drug na na na Necrostatin-1 na TGF-β driver na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33237588 J Cosmet Dermatol 2021 Necrostatin-1, RIP1/RIP3 inhibitor, relieves transforming growth factor β-induced wound-healing process in formation of hypertrophic scars Pei-Ting Lin; Xiao-Dong Xue; Zhong-Dong Zhao; Jun-Yang Lu; Pei-Lin Xie   hypertrophic scars; necrostatin-1; receptor-interacting protein kinase; TGFr β; wound healing. China
33433355 drug na drug na na na Halofuginone DB04866 TGF-β driver na cck8 https://pubmed.ncbi.nlm.nih.gov/33433355 Biomed Pharmacother 2021 Halofuginone regulates keloid fibroblast fibrotic response to TGF-β induction Pierre Marty; Brice Chatelain; Thomas Lihoreau; Marion Tissot; Zélie Dirand; Philippe Humbert; Clémence Senez; Eleonora Secomandi; Ciro Isidoro; Gwenaël Rolin Fibrosis; Halofuginone; Keloid; Myofibroblasts; TGF-β1. France
33141769 drug na drug na na na Metformin DB00331 TGF-β suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33141769 Ann Plast Surg 2021 Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids Hong Bae Jeon; Hyun Roh; Hyo Min Ahn; Ju Hee Lee; Chae Ok Yun; Tai Suk Roh; Won Jai Lee na South Korea
34134955 drug na drug na na na Curcumol na ERK  suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/34134955 Nan Fang Yi Ke Da Xue Xue Bao 2021 [Curcumol inhibits keloid fibroblast proliferation and collagen synthesis through the ERK signaling pathway] W Yuan; H Sun; L Yu; J Wang ERK signaling pathway; collagen synthesis; curcumol; keloid fibroblasts; proliferation. China
34006401 drug na drug na na na Tacrolimus DB00864 TGF-β suppressor na IHC https://pubmed.ncbi.nlm.nih.gov/34006401 An Bras Dermatol 2021 Tacrolimus action pathways in an ointment base for hypertrophic scar prevention in a rabbit ear model Mariana Campos Souza Menezes; Marcelo Buzelin; Cristiana Buzelin Nunes; Luiz Ronaldo Alberti Hypertrophic scar; Keloid; Tacrolimus; Vascular endothelial growth factor, endocrine-gland-derived. Brazil
33709070 drug na drug na na na gold-core spherical nucleic acids na TGF-β1 suppressor increased IF, WB https://pubmed.ncbi.nlm.nih.gov/33709070 ACS Appl Bio Mater 2020 Attenuation of Abnormal Scarring Using Spherical Nucleic Acids Targeting Transforming Growth Factor Beta 1 Adam Ponedal; Shengshuang Zhu; Anthony J Sprangers; Xiao-Qi Wang; David C Yeo; Daniel C S Lio; Mengjia Zheng; Matthew Capek; Suguna P Narayan; Brian Meckes; Amy S Paller; Chenjie Xu; Chad A Mirkin TGF-β; gene regulation; nanomedicine; scar; spherical nucleic acid; topical. USA
33413617 drug na drug na na na adipose-derived stem cell conditioned medium, polysaccharide hydrogel na α-SMA suppressor na IF, IHC https://pubmed.ncbi.nlm.nih.gov/33413617 Stem Cell Res Ther 2021 Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring Chaoyu Zhang; Ting Wang; Li Zhang; Penghong Chen; Shijie Tang; Aizhen Chen; Ming Li; Guohao Peng; Hangqi Gao; Haiyan Weng; Haoruo Zhang; Shirong Li; Jinghua Chen; Liangwan Chen; Xiaosong Chen Adipose-derived stem cells; Conditioned medium; Freeze-drying; Hydrogel; Scar hyperplasia. China
33628711 drug na drug na na na LY2109761 na TGF-β1 suppressor na cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/33628711 Anal Cell Pathol (Amst) 2021 Inhibitory Effect of the LY2109761 on the Development of Human Keloid Fibroblasts Xiuxia Wang; Chuan Gu; Feng Shang; Rui Jin; Jia Zhou; Zhen Gao  na China
32493094 drug na drug na na na Resveratrol DB02709 HIF-1α suppressor na cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32493094 J Plast Surg Hand Surg 2020 Resveratrol inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting HIF-1α Loubin Si; Mingzi Zhang; Enling Guan; Qin Han; Yifang Liu; Xiao Long; Fei Long; Robert Chun-Hua Zhao; Jiuzuo Huang; Zhifei Liu; Ru Zhao; Hailin Zhang; Xiaojun Wang  HIF-1α; collagen synthesis; hypoxia; keloid; resveratrol. China
33062677 drug na drug na na na Wubeizi Ointment na mTOR suppressor na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/33062677 Biomed Res Int 2020 Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway Zhiming Tang; Yi Cao; Jicun Ding; Xiaoxiang Zhai; Mengqing Jing; Mengmeng Wang; Lu Lu na China
32327724 drug na drug na na na Nintedanib DB09079 phosphorylation of multiple kinases suppressor na qRT-PCR, IF https://pubmed.ncbi.nlm.nih.gov/32327724 Acta Pharmacol Sin 2020 Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization Bo-Ya Zhou; Wen-Bo Wang; Xiao-Li Wu; Wen-Jie Zhang; Guang-Dong Zhou; Zhen Gao; Wei Liu MAPK signaling; TGF-β/Smad signaling; anti-keloid activity; ex vivo tissue explant model; keloid fibroblasts; nintedanib. China
32911344 drug na drug na na na Apatite Nanoparticle-Encapsulated siTIMP1 na  TIMP-1  suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32911344 Mol Ther Nucleic Acids 2020 Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars Masayo Aoki; Noriko M Matsumoto; Teruyuki Dohi; Hiroaki Kuwahawa; Satoshi Akaishi; Yuri Okubo; Rei Ogawa; Hirofumi Yamamoto; Kazuaki Takabe ECM; TIMP; abnormal scar; hyprtrophic scar; keloid; nanoparticle; siRNA. Japan
32325772 drug na drug na na na ADP355 na TGF-β1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32325772 Int J Mol Sci 2020 Adiponectin-Based Peptide (ADP355) Inhibits Transforming Growth Factor-β1-Induced Fibrosis in Keloids Claudia C Darmawan; Sara E Montenegro; Gwanghyun Jo; Novi Kusumaningrum; Si-Hyung Lee; Jin-Ho Chung; Je-Ho Mun ADP355; adiponectin; fibrosis; keloid; peptide; scarring; treatment; xenograft. South Korea
32538769 drug na drug na na na Luteolin DB15584 FRAT1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32538769 Cell Mol Biol (Noisy-le-grand) 2020 Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression Xueyan Zhang; Wen Liu; Shuxiang Wei Apoptosis.; FRAT1; Keloid fibroblasts; Luteolin; Proliferation. China
32377718 drug na drug na na na AG490 na JAK2/STAT3  suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/32377718 Int J Mol Med 2020 The JAK2/STAT3 pathway inhibitor, AG490, suppresses the abnormal behavior of keloid fibroblasts in vitro Ying Zhou; Yuexin Sun; Wenjun Hou; Liwen Ma; Yue Tao; Dan Li; Cui Xu; Jun Bao; Weixin Fan na China
32405508 drug na drug na na na Pirfenidone DB04951 epithelial-mesenchymal transition suppressor na qRT-PCR, IF https://pubmed.ncbi.nlm.nih.gov/32405508 Burns Trauma 2020 Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes Latha Satish; Alexander Evdokiou; Eleni Geletu; Jennifer M Hahn; Dorothy M Supp Cell migration; EMT genes; Fibronectin; Keloids; Pirfenidone; Proliferation. USA
31450620 drug na drug na na na Glycyrrhizin DB13751 HMGB1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31450620 Int J Mol Sci 2019 Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis Yeo Reum Jeon; Hyun Roh; Ji Hyuk Jung; Hyo Min Ahn; Ju Hee Lee; Chae-Ok Yun; Won Jai Lee HMGB1; autophagy; glycyrrhizinic acid; keloid. South Korea
31652445 drug na drug na na na BTXA na miR-1587/miR-2392 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31652445 Biosci Rep 2019 BTXA regulates the epithelial-mesenchymal transition and autophagy of keloid fibroblasts via modulating miR-1587/miR-2392 targeted ZEB2 Zhanying Hou; Feixiang Fan; Po Liu Autophagy; BTXA; Epithelial-mesenchymal transition; Keloid; ZEB2; miR-1587/miR-2392. China
31545402 drug na drug na na na CUDC-907 DB11891 PI3K/Akt/mTOR suppressor na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/31545402 Int J Mol Med 2019 CUDC‑907 reverses pathological phenotype of keloid fibroblasts in vitro and in vivo via dual inhibition of PI3K/Akt/mTOR signaling and HDAC2 Tian Tu; Jia Huang; Miaomiao Lin; Zhen Gao; Xiaoli Wu; Wenjie Zhang; Guangdong Zhou; Wenbo Wang; Wei Liu  CUDC‑907, KF, HDAC, PI3K/AKT/mTOR signaling, dual inhibitor China
31341409 drug na drug na na na Metformin DB00331 HIF-1α/PKM2 suppressor na cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31341409 Int J Med Sci 2019 Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway Rui Lei; Shizhen Zhang; Yuming Wang; Siya Dai; Jiaqi Sun; Chaoqun Zhu EMT; HIF-1α; Keloid.; Metformin; PKM2. China
31193978 drug na drug na na na AMF siRNA na RhoA/ROCK1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31193978 Genes Dis 2018 AMF siRNA treatment of keloid through inhibition signaling pathway of RhoA/ROCK1 Yi Tian; Lan Jin; Wenhong Zhang; Zumeng Ya; Yuan Cheng; Hongyun Zhao Autocrine motility factor; Keloid; RhoA; SIRNA; Treatment. China
31059100 drug na drug na na na Trichostatin A DB04297 miR‑30a‑5p suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31059100 Mol Med Rep 2019 Trichostatin A‑induced miR‑30a‑5p regulates apoptosis and proliferation of keloid fibroblasts via targeting BCL2 Xiaoqing Jian; Le Qu; Yunlin Wang; Qianlei Zou; Qing Zhao; Shuang Chen; Xinghua Gao; Hongduo Chen; Chundi He  Trichostatin A, microRNA‑30a‑5p, keloid fibroblast, B‑cell lymphoma 2 China
31137604 drug na drug na na na Hypoxia na ERK suppressor na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/31137604 Int J Mol Sci 2019 Hypoxia-Induced Epithelial-To-Mesenchymal Transition Mediates Fibroblast Abnormalities via ERK Activation in Cutaneous Wound Healing Jihee Kim; Bomi Kim; Soo Min Kim; Chae Eun Yang; Seung Yong Song; Won Jai Lee; Ju Hee Lee 0                ERK; fibroblast; hypoxia; scar; wound healing. South Korea
31341152 drug na drug na na na Hypoxia na HIF-1α suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31341152 Kobe J Med Sci 2019 Role of Hypoxia Inducible Factor-1 Alpha (HIF-1α) in Cytoglobin Expression and Fibroblast Proliferation of Keloids Sri Widia A Jusman; Dewi Hambar Sari; Sri Suciati Ningsih; Novi Silvia Hardiany; Mohamad Sadikin Cygb; Fibroblast; HIF-1α; Ibuprofen; Keloid; Proliferation. Indonesia
31119062 drug na drug na na na rucaparib DB12332 PARP1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/31119062 Adv Wound Care (New Rochelle) 2019 PARP1 Inhibition as a Novel Therapeutic Target for Keloid Disease Tae Hwan Park; Chan Woo Kim; Jin Sik Choi; Yun Joo Park; Yosep Chong; Min Ji Park; Yuri Cho PARP1; fibroblast; keloid; rucaparib. South Korea
30650200 drug na drug na na na OSI-027 DB12387 mTORC1/2 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30650200 Exp Dermatol 2019 Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes Jun Chen; Ke Liu; Yang Liu; Xue Wang; Zhen Zhang  OSI-027 and signalling; cell migration; keloid keratinocytes; mTOR. China
30597173 drug na drug na na na Tension na integrin αvβ3 driver na cck8, qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30597173 Life Sci 2019 Tension enhances cell proliferation and collagen synthesis by upregulating expressions of integrin αvβ3 in human keloid-derived mesenchymal stem cells Haifeng Song; Tao Liu; Wenting Wang; Hailin Pang; Zhe Zhou; Yajie Lv; Tianyu Cao; Da Zhai; Bintao Ma; Huizhong Zhang; Yanguo Zhang Cell proliferation; Collagen synthesis; Integrin αvβ3; Keloid; Mechanical tension; Mesenchymal stem cells. China
30688891 drug na drug na na na Oxandrolone DB00621 na suppressor na scar formation https://pubmed.ncbi.nlm.nih.gov/30688891 Plast Reconstr Surg 2019 Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits Raluca L Sobec; Lucian Fodor; Florian Bodog  na Romania
30662647 drug na drug na na na 2-Methoxyestradiol DB02342 apoptosis suppressor na cck8, qRT-PCR, WB, IF https://pubmed.ncbi.nlm.nih.gov/30662647 Am J Transl Res 2018 2-Methoxyestradiol improves the apoptosis level in keloid fibroblasts through caspase-dependent mechanisms in vitro Ming-Zi Zhang; Yi-Fang Liu, Ning Ding, Peng-Xiang Zhao, Xin Zhang, Meng-Yu Liu, Yao Mawulikplimi Adzavon, Jian-Nan Huang, Xiao Long; Xiao-Jun Wang; You-Bin Wang; Zheng Qi   2-Methoxyestradiol; Keloid; apoptosis; caspase; fibroblast; proliferation. China
30265275 drug na drug na na na Gallic acid na AKT/ERK suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30265275 Acta Biochim Biophys Sin (Shanghai) 2018 Gallic acid inhibits fibroblast growth and migration in keloids through the AKT/ERK signaling pathway Xiuxia Wang; Ke Liu; Mengying Ruan; Jun Yang; Zhen Gao  keloid fibroblasts, gallic acid, proliferation, migration, matrix metalloproteinase China
29809274 drug na drug na na na autophagy inhibitors, MCT4 na autophagy na increased qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29809274 Histol Histopathol 2018 Upregulation of autophagy and glycolysis markers in keloid hypoxic-zone fibroblasts: Morphological characteristics and implications Ryoko Okuno; Yuko Ito; Nabil Eid; Yoshinori Otsuki; Yoichi Kondo; Koichi Ueda  na Japan
29328420 drug na drug na na na Ginsenoside Rg3 na TGF‑β/Smad, ERK suppressor na qRT-PCR, WB, IHC https://pubmed.ncbi.nlm.nih.gov/29328420 Int J Mol Med 2018 Ginsenoside Rg3 inhibits keloid fibroblast proliferation, angiogenesis and collagen synthesis in vitro via the TGF‑β/Smad and ERK signaling pathways Mengyao Tang; Weiwei Bian; Liying Cheng; Lu Zhang; Rong Jin; Wenbo Wang; Yuguang Zhang  wound healing, keloid, ginsenoside Rg3, signaling pathways China
30355933 drug na drug na na na Resveratrol DB02709 Sirt1 driver na cck8, WB https://pubmed.ncbi.nlm.nih.gov/30355933 Cell Physiol Biochem 2018 Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1 Shuang Guo, Hongyan Liao, Jie Liu, Jing Liu, Fanren Tang, Zhongxiang He, Yangchun Li, Qin Yang NIH3T3 cells; Primary cilia; Resveratrol; SRT1720; Sirt1; Sirtinol; Sonic hedgehog signaling. China
29118355 drug na drug na na na sLRP6E1E2 na TGF‑β suppressor na WB https://pubmed.ncbi.nlm.nih.gov/29118355 Sci Rep 2017 Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling Won Jai Lee; Jung-Sun Lee; Hyo Min Ahn; Youjin Na; Chae Eun Yang; Ju Hee Lee; JinWoo Hong; Chae-Ok Yun na South Korea
28346732 drug na drug na na na Asiaticoside DB14081 GDF-9/MAPK/Smad suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28346732 J Biochem Mol Toxicol 2017 Asiaticoside hinders the invasive growth of keloid fibroblasts through inhibition of the GDF-9/MAPK/Smad pathway Xin Wu; Difei Bian; Yannong Dou; Zhunan Gong; Qian Tan; Yufeng Xia; Yue Dai  GDF-9; TGF-β1; asiaticoside; keloid. China
28946718 drug na drug na na na Tamoxifen DB00675 na suppressor na fibrotic tissue thickness, scar surface area, angiogenesis https://pubmed.ncbi.nlm.nih.gov/28946718 Arch Plast Surg 2017 Effects of Topical Tamoxifen on Wound Healing of Burned Skin in Rats Shaban Mehrvarz; Ali Ebrahimi; Hedayat Sahraei; Mohammad Hasan Bagheri; Sima Fazili; Shahram Manoochehry; Hamid Reza Rasouli  Burns; Keloid; Rats; Tamoxifen; Wound healing. Iran
27939785 drug na drug na na na IWR-1 na Wnt/β-catenin suppressor na ELISA, WB https://pubmed.ncbi.nlm.nih.gov/27939785 Life Sci 2017 Inhibition of collagen synthesis by IWR-1 in normal and keloid-derived skin fibroblasts Ming-Wei Zhou; Wei-Tian Yin; Ri-Hua Jiang; Jin-Hyup Lee; Chang-Deok Kim; Jeung-Hoon Lee; Ming Ji Zhu; Tae-Jin Yoon Collagen; Fibroblasts; IWR-1; Keloid; Matrix metalloproteinase. China
28120534 drug na drug na na na Sulforaphane DB12422 IL-6, Stat3, Smad3 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/28120534 Wound Repair Regen 2017 Sulforaphane suppresses cell growth and collagen expression of keloid fibroblasts Ayako Kawarazaki; Mano Horinaka; Shusuke Yasuda; Toshiaki Numajiri; Kenichi Nishino; Toshiyuki Sakai  sulforaphane, keloid fibroblasts, collagen, IL-6, PBMC Japan
27565798 drug na drug na na na Selenium-Enriched Ziyang Green Tea Polysaccharide na TGF-β1, NG2 suppressor na MTT https://pubmed.ncbi.nlm.nih.gov/27565798 Biol Trace Elem Res 2017 A Selenium-Enriched Ziyang Green Tea Polysaccharide Induces Bax-Dependent Mitochondrial Apoptosis and Inhibits TGF-β1-Stimulated Collagen Expression in Human Keloid Fibroblasts via NG2 Inactivation Lele Lu; Linlin Chai; Wenping Wang; Xi Yuan; Shirong Li; Chuan Cao Collagen; Keloid; NG2; TGF-β1; Ziyang green tea polysaccharides. China
27339758 drug na drug na na na Sorafenib DB00398 TGF-β/Smad, MAPK/ERK  suppressor na IF, WB https://pubmed.ncbi.nlm.nih.gov/27339758 J Mol Med (Berl) 2016 Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways Wenbo Wang; Miao Qu; Lan Xu; Xiaoli Wu; Zhen Gao; Tingyu Gu; Wenjie Zhang; Xiaoyan Ding; Wei Liu; Yue-Lei Chen Keloid fibroblast; Keloids; MAPK/ERK signaling; Sorafenib; TGF-β/Smad signaling. China
32263093 drug na drug na na na HBC na na suppressor increased IHC https://pubmed.ncbi.nlm.nih.gov/32263093 J Mater Chem B 2016 A thermosensitive hydroxybutyl chitosan hydrogel as a potential co-delivery matrix for drugs on keloid inhibition Zixian Bao; Ping Gao, Guixue Xia, Zhiguo Wang, Ming Kong, Chao Feng, Xiaojie Cheng, Ya Liu, Xiguang Chen na China
27429849 drug na drug na na na troglitazone DB00197 miR-543 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27429849 Am J Cancer Res 2016 Peroxisome proliferator-activated receptor-γ agonist inhibits collagen synthesis in human keloid fibroblasts by suppression of early growth response-1 expression through upregulation of miR-543 expression Hua-Yu Zhu; Wen-Dong Bai; Hong-Tao Wang; Song-Tao Xie; Ke Tao; Lin-Lin Su; Jia-Qi Liu; Xue-Kang Yang; Jun Li; Yun-Chuan Wang; Ting He; Jun-Tao Han; Da-Hai Hu  Benign tumor; Egr1; PPAR-γ agonist; keloid; miR-543; troglitazone. China
30044067 drug na drug na na na rapamycin DB00877 autophagy suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/30044067 Zhonghua Zheng Xing Wai Ke Za Zhi 2016 [In vitro study of effects and mechanism of rapamycin-induced autophagy in keloid fibroblasts] Jing Gao, Hu Jiao, Rui Cao, Zhigang Yang, Xuejian Sun, Qiang Zhuang, Zuo Xiao, Zuo Yan na China
26101974 drug na drug na na na Tanshinone IIA na Survivin suppressor na CCK8 https://pubmed.ncbi.nlm.nih.gov/26101974 Ann Plast Surg 2016 Tanshinone IIA Inhibits Proliferation and Induces Apoptosis Through the Downregulation of Survivin in Keloid Fibroblasts Gang Chen; Yimin Liang, Xiao Liang, Qingfeng Li, Dalie Liu tanshinone IIA, keloid fibroblasts, cell cycle, apoptosis, survivin China
27279805 drug na drug na na na Vitamin D3, quercetin DB00169, DB04216 na suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/27279805 Ann Burns Fire Disasters 2015 Response of keloid fibroblasts to Vitamin D3 and quercetin treatment - in vitro study K Mathangi Ramakrishnan; M Babu; M S Lakshmi Madhavi apoptosis; keloid fibroblasts; quercetin; vitamin D3. India
25712143 drug na drug na na na steroids na na suppressor na qRT-PCR, IHC, WB https://pubmed.ncbi.nlm.nih.gov/25712143 Br J Dermatol 2015 An abnormality in glucocorticoid receptor expression differentiates steroid responders from nonresponders in keloid disease D Rutkowski; F Syed; L C Matthews; D W Ray; D A McGrouther; R E B Watson; A Bayat  na UK
26054450 drug na drug na na na Aspidin PB na PI-3K/Akt, Smad suppressor na MTT https://pubmed.ncbi.nlm.nih.gov/26054450 Chem Biol Interact 2015 Aspidin PB, a novel natural anti-fibrotic compound, inhibited fibrogenesis in TGF-β1-stimulated keloid fibroblasts via PI-3K/Akt and Smad signaling pathways Rengang Song; Gaofeng Li; Shirong Li Aspidin PB; Keloid fibroblasts; PI-3K/Akt; Smad; TGF-β1. China
26665932 drug na drug na na na Metformin DB00331 Akt/FoxO1 suppressor na CCK8, WB https://pubmed.ncbi.nlm.nih.gov/26665932 Zhonghua Zheng Xing Wai Ke Za Zhi 2015 [The effect of Metformin on the proliferation and collagen synthesis of human keloids fibroblasts] Sun Yi, Ma Weiyuan na China
26111331 drug na drug na na na 17-AAG DB05134 Hsp90 suppressor na WB https://pubmed.ncbi.nlm.nih.gov/26111331 Plast Reconstr Surg 2015 Heat Shock Protein 90 Inhibitor (17-AAG) Induces Apoptosis and Decreases Cell Migration/Motility of Keloid Fibroblasts In Sik Yun; Mi Hee Lee, Dong Kyun Rah, Dae Hyun Lew, Jong-Chul Park, Won Jai Lee na South Korea
25745770 drug na drug na na na genistein DB01645 CTGF na na qRT-PCR, ELISA https://pubmed.ncbi.nlm.nih.gov/25745770 Acta Pol Pharm 2014 Evaluation of genistein ability to modulate CTGF mRNA/protein expression, genes expression of TGFβ isoforms and expression of selected genes regulating cell cycle in keloid fibroblasts in vitro Magdalena Jurzak, Katarzyna Adamczyk, Paweł Antończak, Agnieszka Garncarczyk, Dariusz Kuśmierz, Małgorzata Latocha keloids, fibroproliferative disorders, genistein, connective tissue growth factor, transforminggrowth factor, cell cycle Poland
24122729 drug na drug na na na botulinum toxin A DB00083 na no effect na ELISA  https://pubmed.ncbi.nlm.nih.gov/24122729 Laryngoscope 2014 Effects of botulinum toxin A on patient-specific keloid fibroblasts in vitro Frank Haubner; Michaela Leyh, Elisabeth Ohmann, Haneen Sadick, Holger G Gassner Keloids; botulinum toxin; cytokines; fibroblasts. Germany
25328513 drug na drug na na na tolfenamic Acid DB09216 apoptosis suppressor na IF, WB https://pubmed.ncbi.nlm.nih.gov/25328513 Dermatol Res Pract 2014 The preliminary study of effects of tolfenamic Acid on cell proliferation, cell apoptosis, and intracellular collagen deposition in keloid fibroblasts in vitro Dan Yi; Ji Bihl; Mackenzie S Newman; Yanfang Chen; Richard Simman na USA
25171116 drug na drug na na na Astragalus and Salvia miltiorrhiza extract na TGF-β/Smad suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/25171116 Dermatology 2014 Compound Astragalus and Salvia miltiorrhiza extract suppresses rabbits' hypertrophic scar by modulating the TGF-β/Smad signal Chao Wu; Jiemei Jiang, Alex Boye, Yufeng Jiang, Yan Yang CASE; Hypertrophic scar; TGF-β1; Smads; Animal
experiment 		China
24471776 drug na drug na na na simvastatin DB00641 TGF-β1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/24471776 Wound Repair Regen 2014 Simvastatin inhibits transforming growth factor-β1-induced expression of type I collagen, CTGF, and α-SMA in keloid fibroblasts Je-Ho Mun; Young-Mi Kim, Byung-Soo Kim, Jae-Ho Kim, Moon-Bum Kim, Hyun-Chang Ko na South Korea
24936445 drug na drug na na na Hyaluronic Acid DB08818 na suppressor na WB, ELISA https://pubmed.ncbi.nlm.nih.gov/24936445 J Am Coll Clin Wound Spec 2013 Role of Hyaluronic Acid Treatment in the Prevention of Keloid Scarring Andrea Hoffmann; Jessica Lynn Hoing; Mackenzie Newman; Richard Simman  Hyaluronic acid; Keloid; Scarring. USA
24228511 drug na drug na na na 5-aza-2-deoxycytidine na TGF-β/Smad suppressor na WB, IF https://pubmed.ncbi.nlm.nih.gov/24228511 Zhonghua Zheng Xing Wai Ke Za Zhi 2013 [Effect of the methylation enzyme inhibitors of 5-aza-2-deoxycytidine on the TGF-beta/smad signal transduction pathway in human keloid fibroblasts] Qi-Pa Zou; E Yang, Heng-Shu Zhang na China
23815229 drug na drug na na na Resveratrol DB02709 na suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/23815229 Wound Repair Regen 2013 Resveratrol inhibits fibrogenesis and induces apoptosis in keloid fibroblasts Kanae Ikeda; Toshihiko Torigoe, Yoshitaka Matsumoto, Tatsuya Fujita, Noriyuki Sato, Takatoshi Yotsuyanagi na Japan
23500539 drug na drug na na na Thalidomide DB01041 TGF-β1 suppressor na IHC, WB https://pubmed.ncbi.nlm.nih.gov/23500539 Biochem Pharmacol 2013 Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway Chan-Jung Liang; Yu-Hsiu Yen, Ling-Yi Hung, Shu-Huei Wang, Chi-Ming Pu, Hsiung-Fei Chien, Jaw-Shiun Tsai, Chiang-Wen Lee, Feng-Lin Yen, Yuh-Lien Chen na China
23503720 drug na drug na na na silibinin DB09298 collagen I suppressor na IHC  https://pubmed.ncbi.nlm.nih.gov/23503720 Int J Mol Med 2013 Downregulation of type I collagen expression in silibinin-treated human skin fibroblasts by blocking the activation of Smad2/3-dependent signaling pathways: potential therapeutic use in the chemoprevention of keloids Jae-We Cho; Kwon-Jun Il, Kyu-Suk Lee type I collagen, silibinin, fibroblasts, Smad South Korea
23303455 drug na drug na na na KU-0063794, KU-0068650 na TORC1, TORC2 suppressor na IHC, WB, IF https://pubmed.ncbi.nlm.nih.gov/23303455 J Invest Dermatol 2013 Potent dual inhibitors of TORC1 and TORC2 complexes (KU-0063794 and KU-0068650) demonstrate in vitro and ex vivo anti-keloid scar activity Farhatullah Syed; Hitesh J Sanganee, Subir Singh, Ashwani Bahl, Ardeshir Bayat na UK
23709452 drug na drug na na na botulinum toxin type A DB00083 na suppressor na miRNA array  https://pubmed.ncbi.nlm.nih.gov/23709452 Aesthet Surg J 2014 Effects of botulinum toxin type A on expression of genes in keloid fibroblasts Wang Xiaoxue; Chen Xi, Xiao Zhibo botulinum toxin type A; fibroblast; gene expression; invasive growth; keloid; research. China
24250248 drug na drug na na na Asiatic acid DB14054 PPAR-γ suppressor na MTT, WB https://pubmed.ncbi.nlm.nih.gov/24250248 Int J Biol Sci 2013 Asiatic acid isolated from Centella asiatica inhibits TGF-β1-induced collagen expression in human keloid fibroblasts via PPAR-γ activation Difei Bian; Jizhou Zhang, Xin Wu, Yannong Dou, Yan Yang, Qian Tan, Yufeng Xia, Zhunan Gong, Yue Dai PPAR-γ; TGF-β1; asiatic acid; collagen; keloid. China
22435440 drug na drug na na na Oxymatrine DB16276 TGF-β/Smad suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/22435440 Int J Dermatol 2012 Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway Dong-Liang Fan; Wei-Jin Zhao, Yu-Xin Wang, Si-Yuan Han, Shu Guo na China
22033529 drug na drug na na na Pirfenidone DB04951 na na na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/22033529 Arch Dermatol Res 2012 Pirfenidone suppresses keloid fibroblast-embedded collagen gel contraction Masuyoshi Saito; Masashi Yamazaki, Tatsuo Maeda, Hajime Matsumura, Yasuhiro Setoguchi, Ryoji Tsuboi Collagen gel contraction;  Pirfenidone;
Keloid;  Fibroblasts 		Japan
21967214 drug na drug na na na Astragalus and Salvia miltiorrhiza extract na TGF-β/Smad na na qRT-PCR, WB, IF https://pubmed.ncbi.nlm.nih.gov/21967214 Br J Dermatol 2012 Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-β / Smad pathway S He; Y Yang, X Liu, W Huang, X Zhang, S Yang, X Zhang na Japan
21999945 drug na drug na na na Hypoxia na HIF1 suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/21999945 J Dermatol Sci 2012 Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1 Karine Deschene; Christophe Céleste, Derek Boerboom, Christine L Theoret miRNA;  Keloid; tissue  Normal skin tissue Canada
21400246 drug na drug na na na Trichostatin A DB04297 collagen suppressor na WB, IF, MTT https://pubmed.ncbi.nlm.nih.gov/21400246 Arch Dermatol Res 2011 Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts Jian-Sheng Diao; Wen-Sen Xia, Cheng-Gang Yi, Ying-Mei Wang, Bing Li, Wei Xia, Bei Liu, Shu-Zhong Guo, Xu-De Sun Keloid; Trichostatin A; TGFr-b; Apoptosis China
21240513 drug na drug na na na Asiaticoside DB14081 TGF-β/Smad suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/21240513 Arch Dermatol Res 2011 Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts Bing Tang; Bin Zhu, Yueying Liang, Liangkuan Bi, Zhicheng Hu, Bin Chen, Kai Zhang, Jiayuan Zhu Asiaticoside; TGFr-b; Smad Collagen; Keloid China
23614275 drug na drug na na na genistein DB01645 AP-1 suppressor na qRT-PCR https://pubmed.ncbi.nlm.nih.gov/23614275 Acta Pol Pharm 2013 Influence of genistein on c-Jun, c-Fos and Fos-B of AP-1 subunits expression in skin keratinocytes, fibroblasts and keloid fibroblasts cultured in vitro Magdalena Jurzak; Katarzyna Adamczyk genistein, keratinocytes, fibroblasts, keloid fibroblasts, activator protein ñ 1, C-JUN, CFOS, FOS-B. Poland
23278899 drug na drug na na na Aneilema keisak extract na TGF-β/Smad suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/23278899 Exp Dermatol 2013 Extract of Aneilema keisak inhibits transforming growth factor-β-dependent signalling by inducing Smad2 downregulation in keloid fibroblasts Won-Serk Kim, Ji-Seon Lee, Gab-Yong Bae, Jin-Ju Kim, Young-Won Chin, Young Yil Bahk, Hyung Geun Min, Hyuk-Jin Cha Aneilema keisak – fibrotic response – keloid fibroblasts –Smad2 – TGF-b South Korea
22982188 drug na drug na na na  Palomid 529 DB12812 tORC1/2 suppressor na IHC https://pubmed.ncbi.nlm.nih.gov/22982188 Am J Pathol 2012 Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor Farhatullah Syed; David Sherris, Ralf Paus, Shohreh Varmeh, Subir Singh, Pier P Pandolfi, Ardeshir Bayat na UK
22705642 drug na drug na na na SMAD3 antisense oligonucleotides na na suppressor na atomic force microscopy https://pubmed.ncbi.nlm.nih.gov/22705642 Eur J Pharm Biopharm 2012 Cellular delivery of cationic lipid nanoparticle-based SMAD3 antisense oligonucleotides for the inhibition of collagen production in keloid fibroblasts Su-Eon Jin; Chong-Kook Kim, Yang-Bae Kim Cationic lipid; nanoparticles;
SMAD3;
Antisense; oligonucleotides;
Cellular delivery;
Keloid fibroblasts;
Fibrosis 		South Korea
22540338 drug na drug na na na tacrolimus DB00864 TGF-β/Smad suppressor na RT-PCR, qPCR, WB https://pubmed.ncbi.nlm.nih.gov/22540338 Br J Dermatol 2012 FK506 inhibits the enhancing effects of transforming growth factor (TGF)-β1 on collagen expression and TGF-β/Smad signalling in keloid fibroblasts: implication for new therapeutic approach C-S Wu; P-H Wu, A-H Fang, C-C E Lan na China
22360962 drug na drug na na na Madecassoside DB15532 p38 kinase and PI3K suppressor na migration assays and scratch-wound-closure assays https://pubmed.ncbi.nlm.nih.gov/22360962 Burns 2012 Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways Jie Song; Huan Xu, Qian Lu, Zhao Xu, Difei Bian, Yufeng Xia, Zhifeng Wei, Zhunan Gong, Yue Dai Madecassoside;
Keloid;
Fibroblast;
Migration;
Cofilin;
PI3K;
MAPK 		China
24489452 drug na drug na na na omega-3 Fatty acids DB11133 na na increased Cell growth https://pubmed.ncbi.nlm.nih.gov/24489452 Wounds 2011 Inhibitory activities of omega-3 Fatty acids and traditional african remedies on keloid fibroblasts Peter B Olaitan; I-Ping Chen; James E C Norris; Richard Feinn; Odunayo M Oluwatosin; Ernst J Reichenberger na Nigeria
21070203 drug na drug na na na Vitamin D DB11094 na suppressor na qRT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/21070203 Br J Dermatol 2011 Vitamin D: a novel therapeutic approach for keloid, an in vitro analysis G Y Zhang; T Cheng, Q Luan, T Liao, C L Nie, X Zheng, X G Xie, W Y Gao na China
21269347 drug na drug na na na mitomycin C DB00305 na suppressor na Cell growth https://pubmed.ncbi.nlm.nih.gov/21269347 Dermatol Surg 2011 Ear keloids as a primary candidate for the application of mitomycin C after shave excision: in vivo and in vitro study Seong Geun Chi; Jun Young Kim, Weon Ju Lee, Seok-Jong Lee, Do Won Kim, Mi Yeung Sohn, Gun Wook Kim, Moon Bum Kim, Byung Soo Kim Fibroblasts, Keloid, Phototherapy, Lasers, Skin, Laser Therapy, Low-Level. South Korea
20717830 drug na drug na na na curcuminoids na TGF-β1/SMAD suppressor na HPLC, WB https://pubmed.ncbi.nlm.nih.gov/20717830 Arch Dermatol Res 2010 Suppression of TGF-β1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid Yi-Chiang Hsu; Ming-Jenn Chen, Ya-Mei Yu, Shun-Yao Ko, Chi-Chang Chang Keloid, Curcuminoids, Extracellular matrix, TGF-b1 China
20633010 drug na drug na na na 5-fluorouracil DB00544 apoptosis suppressor na MTT, WB https://pubmed.ncbi.nlm.nih.gov/20633010 Br J Dermatol 2010 Low-dose 5-fluorouracil induces cell cycle G2 arrest and apoptosis in keloid fibroblasts L Huang; Y P Wong, Y J Cai, I Lung, C S Leung, A Burd 5-fluorouracil, keloid, fibroblast, cell cycle arrest,
apoptosis 		China
20944123 drug na drug na na na TGF-ß1 antisense na SMAD na decreased IHC https://pubmed.ncbi.nlm.nih.gov/20944123 Anticancer Res 2010 TGF-ß1 antisense impacts the SMAD signalling system in fibroblasts from keloid scars Gregor M Bran; Ulrich J Sommer, Ulrich R Goessler, Karl Hörmann, Frank Riedel, Haneen Sadick TGF-β1, antisense, keloid, SMAD, fibroblast Germany
20163451 drug na drug na na na Vitamin C DB14482 LL-37 na na RT-PCR https://pubmed.ncbi.nlm.nih.gov/20163451 Exp Dermatol 2010 Vitamin C attenuates ERK signalling to inhibit the regulation of collagen production by LL-37 in human dermal fibroblasts Hyun Jeong Park; Sun Myeong Ock, Hee Jung Kim, Hong Jin Park, Young Bok Lee, Jung Min Choi, Chul Soo Cho, Jun Young Lee, Baik Kee Cho, Dae Ho Cho ERK, human dermal fibroblasts, LL-37,
Vitamin C 		South Korea
20620621 drug na drug na na na TGF-β antisense oligonucleotides na MMPs suppressor na IHC, ELISA https://pubmed.ncbi.nlm.nih.gov/20620621 Otolaryngol Head Neck Surg 2010 Effect of transforming growth factor-beta1 antisense oligonucleotides on matrix metalloproteinases and their inhibitors in keloid fibroblasts Gregor M Bran; Ulrich R Goessler, Ariton Baftiri, Karl Hormann, Frank Riedel, Haneen Sadick na Germany
19617014 drug na drug na na na troglitazone DB00197 PPAR-γ suppressor na RT-PCR, ELISA https://pubmed.ncbi.nlm.nih.gov/19617014 J Plast Reconstr Aesthet Surg 2010 Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts Guo-You Zhang; Tao Cheng, Ming-Hua Zheng, Cheng-Gang Yi, Hua Pan, Zhi-Jie Li, Xing-Long Chen, Qing Yu, Liang-Fu Jiang, Fei-Ya Zhou, Xiao-Yang Li, Jing-Quan Yang, Ting-Gang Chu, Wei-Yang Gao Peroxisome ProliferatorActivated Receptor-g; Troglitazone; TGFr-b1; Collagen I; Fibronection; Dermal fibrosis China
20464356 drug na drug na na na TGF-β antisense oligonucleotides na Integrin suppressor na IHC, WB https://pubmed.ncbi.nlm.nih.gov/20464356 HNO 2010 [Impact of TGF-beta1 antisense on collagen-binding integrins in keloid] G Bran; U Sommer, F Meinzer, U R Goessler, K Hörmann, F Riedel, H Sadick na Deutschland
19546682 drug na drug na na na camptothecin DB04690 collagen suppressor na MTT, RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/19546682 Ann Plast Surg 2009 Effect of camptothecin on collagen synthesis in fibroblasts from patients with keloid Guo-You Zhang; Wei-Yang Gao, Xuan Li, Cheng-Gang Yi, Yan Zheng, Yang Li, Bo Xiao, Xian-Jie Ma, Li Yan, Kai-Hua Lu, Yan Han, Shu-Zhong Guo wound healing, keloid, camptothecin, collagen, fibrosis, topoisomerase China
19803206 drug na drug na na na tunicamycin DB13172  Fas  suppressor na WB, Flow cytometry https://pubmed.ncbi.nlm.nih.gov/19803206 Zhonghua Zheng Xing Wai Ke Za Zhi 2009 [The effect of tunicamycin on Fas protein expression and its function in fibroblasts from hypertrophic scar and keloid] Yong-Bo Liu; Jian-Hua Gao, Xiao-Jun Liu, Feng Lu, Hong-Wei Liu na China
19120328 drug na drug na na na Troglitazone DB00197 TGF-β1 suppressor na RT-PCR https://pubmed.ncbi.nlm.nih.gov/19120328 Br J Dermatol 2009 Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts G-Y Zhang; C-G Yi, X Li, B Ma, Z-J Li, X-L Chen, S-Z Guo, W-Y Gao collagen, keloid, peroxisome proliferator-activated
receptor-c, TGFr-b1,
wound healing 		China
18463684 drug na drug na na na Green tea polyphenol epigallocatechin-3-gallate na STAT3 suppressor na IHC, WB https://pubmed.ncbi.nlm.nih.gov/18463684 J Invest Dermatol 2008 Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway Gyuman Park; Byung Sun Yoon, Jai-Hee Moon, Bona Kim, Eun Kyoung Jun, Sejong Oh, Hyunggee Kim, Hea Joon Song, Joo Young Noh, Chilhwan Oh, Seungkwon You na South Korea
18406579 drug na drug na na na DHMEQ na NF-κB suppressor na IHC, WB https://pubmed.ncbi.nlm.nih.gov/18406579 J Dermatol Sci 2008 DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts Sachio Makino; Norisato Mitsutake, Masahiro Nakashima, Vladimir A Saenko, Akira Ohtsuru, Kazuo Umezawa, Katsumi Tanaka, Akiyoshi Hirano, Shunichi Yamashita na Japan
17943180 drug na drug na na na Lys[Z(NO(2))]-thiazolidide, Lys[Z(NO(2))]-pyrrolidide na dipeptidyl peptidase IV suppressor na WB, ELISA https://pubmed.ncbi.nlm.nih.gov/17943180 J Invest Dermatol 2008 Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts Anja Thielitz; Robert W Vetter, Bianca Schultze, Sabine Wrenger, Luca Simeoni, Siegfried Ansorge, Klaus Neubert, Jürgen Faust, Petra Lindenlaub, Harald P M Gollnick, Dirk Reinhold na German
18087663 drug na drug na na na TGF-β antisense oligonucleotides na HGF/SF suppressor na IHC, WB https://pubmed.ncbi.nlm.nih.gov/18087663 Aesthetic Plast Surg 2008 Transforming growth factor-beta1-antisense modulates the expression of hepatocyte growth factor/scatter factor in keloid fibroblast cell culture R Naim; A Naumann, J Barnes, A Sauter, K Hormann, D Merkel, W Aust, T Braun, M Bloching Antisense; Fibroblasts; HGF/SF;
Keloid; Scar; TGF-b1 		Germany
17959227 drug na drug na na na tTGFbetaRII na na suppressor na RT-PCR, WB https://pubmed.ncbi.nlm.nih.gov/17959227 Hum Pathol 2008 Macrophage and TGF-beta immunohistochemical expression in Jorge Lobo's disease Marilia Brasil Xavier; Rosana Maria Feio Libonati, Débora Unger, Clívia Oliveira, Carlos Eduardo Pereira Corbett, Arival Cardoso de Brito, Juarez Antonio Simões Quaresma Lacaziosis; Immunopathology; Lacazia loboi; Cytokine Brazil
17550447 drug na drug na na na aspirin DB00945 NF-κB suppressor na WB, Flow cytometry https://pubmed.ncbi.nlm.nih.gov/17550447 Dermatol Surg 2007 Abnormal nuclear factor (NF)-kappaB signal pathway and aspirin inhibits tumor necrosis factor alpha-induced NF-kappaB activation in keloid fibroblasts Guiying Zhu; Jinglong Cai, Jie Zhang, Yueran Zhao, Bin Xu na China
17722521 drug na drug na na na onion extract na na suppressor na recovery https://pubmed.ncbi.nlm.nih.gov/17722521 J Wound Care 2007 The effects of onion extract on hypertrophic and keloid scars M Hosnuter; C Payasli, A Isikdemir, B Tekerekoglu na Turkey
17263819 drug na drug na na na mitomycin C DB00305 na suppressor na recurrence https://pubmed.ncbi.nlm.nih.gov/17263819 Br J Dermatol 2007 Application of topical mitomycin C to the base of shave-removed keloid scars to prevent their recurrence J N R Bailey; A E Waite, W J Clayton, M H A Rustin collagen, fibroblast, keloid, mitomycin UK
17052928 drug na drug na na na nitric oxide DB00435 TGF-β1 driver na WB, ELISA https://pubmed.ncbi.nlm.nih.gov/17052928 Nitric Oxide 2007 Exogenous nitric oxide stimulated collagen type I expression and TGF-beta1 production in keloid fibroblasts by a cGMP-dependent manner Yi-Chiang Hsu; Michael Hsiao, Yie W Chien, Woan-Ruoh Lee NO; cGMP; PDE; TGF-1 China
17145168 drug na drug na na na nitric oxide DB00435 TIMP-1, HSP47 driver na ELISA https://pubmed.ncbi.nlm.nih.gov/17145168 J Dermatol Sci 2007 Induction of TIMP-1 and HSP47 synthesis in primary keloid fibroblasts by exogenous nitric oxide Yi-Chiang Hsu; Leng-Fang Wang, Yie W Chien, Woan-Ruoh Lee NO; HSP4; TIMP-1 China
16575391 drug na drug na na na dexamethasone DB01234 VEGF suppressor na IHC, RT-PCR https://pubmed.ncbi.nlm.nih.gov/16575391 J Invest Dermatol 2006 Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation Wen-Sheng Wu; Feng-Sheng Wang, Kuender D Yang, Chao-Cheng Huang, Yur-Ren Kuo na China
15978417 drug na drug na na na SB-431542 na TGF-β1 suppressor na IF, WB https://pubmed.ncbi.nlm.nih.gov/15978417 J Dermatol Sci 2005 SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts Toshio Hasegawa; Atsuhito Nakao, Koji Sumiyoshi, Hitoshi Tsuchihashi, Hideoki Ogawa SB-431542; TGF-b; Smad; Fibroblasts; Contraction Japan
15580028 drug na drug na na na quercetin DB04216 TGF-β/SMAD suppressor na WB https://pubmed.ncbi.nlm.nih.gov/15580028 J Trauma 2004 Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars Toan-Thang Phan; Ivor Jiun Lim, Sui-Yung Chan, Ee-Kim Tan, Seng-Teik Lee, Michael T Longaker TGF-β, Smad, Keloid, Fibroblasts, Quercetin Singapore
15306200 drug na drug na na na PKC412 na apoptosis suppressor na WB https://pubmed.ncbi.nlm.nih.gov/15306200 Eur J Pharmacol 2004 PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts Ayako Nakazono-Kusaba; Fumi Takahashi-Yanaga, Yoshikazu Miwa, Sachio Morimoto, Masutaka Furue, Toshiyuki Sasaguri Apoptosis; PKC412; Staurosporine; Caspase Japan
15312464 drug na drug na na na TGF-β antisense oligonucleotides na TGF-β  suppressor na RT-PCR, fluorescent microscope https://pubmed.ncbi.nlm.nih.gov/15312464 Zhonghua Shao Shang Za Zhi 2004 [Effects of antisense oligonucleotides on the expression of connective tissue growth factor gene and on the collagen synthesis in the cultured human keloid fibroblasts] Jian-Yi Liu; Shi-Rong Li, Shu-Xing Ji na China
14739495 drug na drug na na na Sphingosine DB03203 apoptosis suppressor na LDH, MTT https://pubmed.ncbi.nlm.nih.gov/14739495 J Dermatol 2004 Sphingosine may have cytotoxic effects via apoptosis on the growth of keloid fibroblasts Sung-Eun Chang; Kyoung-Jin Kim, Kyoung-Hyun Ro, Young-Jin Lim, Jee-Ho Choi, Kee-Chan Moon, Kyung-Jeh Sung sphingosine; keloid; cytotoxic effect via apoptosis South Korea
14643528 drug na drug na na na Quercetin DB04216 fibronectin suppressor na WB, Transmission electron microscopy https://pubmed.ncbi.nlm.nih.gov/14643528 J Dermatol Sci 2003 Quercetin inhibits fibronectin production by keloid-derived fibroblasts. Implication for the treatment of excessive scars T T Phan, I J Lim, L Sun, S Y Chan, B H Bay, E K Tan, S T Lee na Singapore
14708599 drug na drug na na na hypoxic na PAI-1 na increased WB, RT-PCR https://pubmed.ncbi.nlm.nih.gov/14708599 J Invest Dermatol 2003 Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts Qunzhou Zhang; Yidi Wu, David K Ann, Diana V Messadi, Tai-Lan Tuan, A Paul Kelly, Charles N Bertolami, Anh D Le na USA
12920208 drug na drug na na na 5-Fluorouracil DB00544 c-Jun NH2-terminal kinase suppressor na WB https://pubmed.ncbi.nlm.nih.gov/12920208 Mol Pharmacol 2003 5-fluorouracil blocks transforming growth factor-beta-induced alpha 2 type I collagen gene (COL1A2) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation Jeanne Wendling; Aimé Marchand, Alain Mauviel, Franck Verrecchia na France
14756522 drug na drug na na na Tretinoin DB00755 MMP-13 suppressor increased ELISA, RT-PCR https://pubmed.ncbi.nlm.nih.gov/14756522 Exp Dermatol 2003 Tretinoin reverses upregulation of matrix metalloproteinase-13 in human keloid-derived fibroblasts Gentaro Uchida; Kotaro Yoshimura, Yukie Kitano, Mutsumi Okazaki, Kiyonori Harii na Japan
12545112 drug na drug na na na mitomycin C DB00305 na suppressor na cell growth https://pubmed.ncbi.nlm.nih.gov/12545112 Ann Plast Surg 2003 Effect of mitomycin C on keloid fibroblasts: an in vitro study Richard Simman; Hashim Alani, Frances Williams na USA
12445185 drug na drug na na na Staurosporine DB02010 apoptosis suppressor na IF, WB https://pubmed.ncbi.nlm.nih.gov/12445185 J Invest Dermatol 2002 Staurosporine-induced cleavage of alpha-smooth muscle actin during myofibroblast apoptosis Ayako Nakazono-Kusaba; Fumi Takahashi-Yanaga, Sachio Morimoto, Masutaka Furue, Toshiyuki Sasaguri na Japan
12174062 drug na drug na na na Triamcinolone DB00620 bFGF, TGF-β1 suppressor na ELISA  https://pubmed.ncbi.nlm.nih.gov/12174062 Dermatol Surg 2002 Triamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblasts Lisa A Carroll; Matthew M Hanasono, Anthony A Mikulec, Magdalena Kita, R James Koch na USA
11978562 drug na drug na na na Lysine acetylsalicylate DB00945 extracellular matrix suppressor na WB https://pubmed.ncbi.nlm.nih.gov/11978562 Eur J Dermatol 2002 Lysine acetylsalicylate decreases proliferation and extracellular matrix gene expression rate in keloid fibroblasts in vitro Jean-Bernhard Petri; Uwe-Frithjof Haustein na Germany
12653748 drug na drug na na na quercetin DB04216 IGF, collagen na na MTT, Northern blot, WB https://pubmed.ncbi.nlm.nih.gov/12653748 Br J Dermatol 2003 Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids T T Phan; P See, E Tran, T T T Nguyen, S Y Chan, S T Lee, H Huynh collagen, insulin-like growth factor, keloid, quercetin, therapy Singapore
11838050 drug na drug na na na TGF-β antisense oligonucleotides na na suppressor na cell growth https://pubmed.ncbi.nlm.nih.gov/11838050 Zhonghua Zheng Xing Wai Ke Za Zhi 2001 [An experimental study of antisense TGF-beta 1 inhibiting keloid fibroblast proliferation in vitro] Q Shang; R Yuan, W Wang na China
11781498 drug na drug na na na Tranilast DB07615 TGF-a1 na na RT-PCR https://pubmed.ncbi.nlm.nih.gov/11781498 Kobe J Med Sci 2001 Tranilast inhibits TGF- A1 secretion without affecting its mRNA levels in conjunctival cells H Ochiai; Y Ochiai, E Chihara Tranilast; TGF- β 1; secretion; Chang Conjunctiva cells; Filtration bleb; glaucoma filtration surgery Japan
11368663 drug na drug na na na  tamoxifen DB00675 TGF-β1 na increased ELISA https://pubmed.ncbi.nlm.nih.gov/11368663 Arch Facial Plast Surg 2001 Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts A A Mikulec; M M Hanasono, J Lum, J M Kadleck, M Kita, R J Koch na USA
10340860 drug na drug na na na Hypoxia na VEGF na increased ELISA  https://pubmed.ncbi.nlm.nih.gov/10340860 Ann Plast Surg 1999 Hypoxia upregulates VEGF production in keloid fibroblasts D S Steinbrech; B J Mehrara, D Chau, N M Rowe, G Chin, T Lee, P B Saadeh, G K Gittes, M T Longaker na USA
9128765 drug na drug na na na hexadecylphosphocholine DB09031 fibronectin, integrin suppressor na Cell growth,  immunoprecipitation https://pubmed.ncbi.nlm.nih.gov/9128765 Arch Dermatol Res 1997 The phospholipid analogue hexadecylphosphocholine (HePC) inhibits proliferation of keloid fibroblasts in vitro and modulates their fibronectin and integrin synthesis U Blume-Peytavi; C C Geilen, C Sommer, B Almond-Roesler, C E Orfanos Hexadecylphosphocholine; Keloid; Hypertrophic scars; Antiproliferative drugs; Fibronectin; Integrin Germany
7798630 drug na drug na na na Oncostatin M na na no effect na recurrence, WB https://pubmed.ncbi.nlm.nih.gov/7798630 J Invest Dermatol 1995 Oncostatin M stimulates collagen and glycosaminoglycan production by cultured normal dermal fibroblasts: insensitivity of sclerodermal and keloidal fibroblasts M R Duncan; A Hasan, B Berman na USA
7537081 drug na drug na na na Tranilast DB07615 collagen suppressor na Cell growth https://pubmed.ncbi.nlm.nih.gov/7537081 J Dermatol Sci 1995 Tranilast inhibits collagen synthesis in normal, scleroderma and keloid fibroblasts at a late passage culture but not at an early passage culture H Yamada; S Tajima, T Nishikawa Collagen; Keloid; Scleroderma; Tranilast Japan
7533764 drug na drug na na na Tranilas DB07615 collagen suppressor na Northern blot https://pubmed.ncbi.nlm.nih.gov/7533764 J Biochem 1994 Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts H Yamada; S Tajima, T Nishikawa, S Murad, S R Pinnell na Japan
2206972 drug na drug na na na Pentoxifylline DB00806 collagen suppressor na Cell growth https://pubmed.ncbi.nlm.nih.gov/2206972 Br J Dermatol 1990 Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin B Berman; M R Duncan na USA
1974259 drug na drug na na na dexamethasone DB01234 protein kinase C suppressor na WB https://pubmed.ncbi.nlm.nih.gov/1974259 J Cell Biochem 1990 Suppression of protein kinase C and the stimulation of glucocorticoid receptor synthesis by dexamethasone in human fibroblasts derived from tumor tissue P Gadson; J McCoy, A C Wikström, J A Gustafsson protein kinase C, glucocorticoid, dexamethasone, fibroblast, tumor tissue USA
3036858 drug na drug na na na ethyl-3,4-dihydroxybenzoate na prolyl hydroxylase suppressor na radioimmunoprecipitation https://pubmed.ncbi.nlm.nih.gov/3036858 J Biol Chem 1987 Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action T Sasaki, K Majamaa, J Uitto na USA
3994409 drug na drug na na na Retinoid na collagen suppressor na radioimmunoprecipitation https://pubmed.ncbi.nlm.nih.gov/3994409 Arch Dermatol 1985 Retinoid modulation of connective tissue metabolism in keloid fibroblast cultures R P Abergel, C A Meeker, H Oikarinen, A I Oikarinen, J Uitto na USA
701387 drug na drug na na na hydrocortisone DB00741 collagen suppressor na cell growth https://pubmed.ncbi.nlm.nih.gov/701387 J Cell Physiol 1978 Differential effects of hydrocortisone on both growth and collagen metabolism of human fibroblasts from normal and keloid tissue J D Russell, S B Russell, K M Trupin na USA
591568 drug na drug na na na histamine  DB05381 na driver na cell growth https://pubmed.ncbi.nlm.nih.gov/591568 J Cell Physiol 1977 The effect of histamine on the growth of cultured fibroblasts isolated from normal and keloid tissue J D Russel, S B Russell, K M Trupin na USA
6114504 drug na drug na na na diphenhydramine hydrochloride DB01075 histamine suppressor na cell growth https://pubmed.ncbi.nlm.nih.gov/6114504 Plast Reconstr Surg 1981 The use of antihistamine to retard the growth of fibroblasts derived from human skin, scar, and keloid B M Topol, V L Lewis Jr, K Benveniste na USA



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